Article
Oncology
Akira Yorozu, Shohei Sekiguchi, Akira Takasawa, Fumika Okazaki, Takeshi Niinuma, Hiroshi Kitajima, Eiichiro Yamamoto, Masahiro Kai, Mutsumi Toyota, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Kazufumi Obata, Makoto Kurose, Atsushi Kondo, Makoto Osanai, Akihiro Miyazaki, Kenichi Takano, Hiromu Suzuki
Summary: The expression of CXCL12 in the tumor microenvironment of oral squamous cell carcinoma (OSCC) has both biological and clinical significance. CXCL12 is mainly expressed in stromal cells within the tumor tissue, and its expression level is negatively correlated with muscle structure disruption and overall survival. Furthermore, CXCL12 expression is associated with tumor infiltration and infiltration of CD8+ lymphocytes.
Article
Nutrition & Dietetics
Yu-Ching Lin, Hang Huong Ling, Pei-Hung Chang, Yi-Ping Pan, Cheng-Hsu Wang, Wen-Chi Chou, Fang-Ping Chen, Kun-Yun Yeh
Summary: This study evaluated the difference in treatment-interval total body composition changes between oral cavity cancer patients with adjuvant CCRT and non-oral cavity cancer patients with primary CCRT. The study found that body composition parameters were progressively lost during CCRT in both subgroups, with different factors independently correlated with the interval changes of each body composition parameter for both groups.
Article
Biochemistry & Molecular Biology
Tatjana Zejc, Jorg Piontek, Jorg-Dieter Schulzke, Michael Fromm, Jurgen Ervens, Rita Rosenthal
Summary: The study compares the expression of claudins in oral squamous cell carcinoma (OSCC) and healthy oral epithelium, and finds that the expression levels of claudin-2, -4, and -7 are associated with the diagnosis and prognosis of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Yijie Zhao, Dongyi Chen, Junhao Yin, Jian Xie, Chun-yu Sun, Mengmeng Lu
Summary: This study investigates the significance of tumor immune microenvironment (TIME) cells in oral squamous cell carcinoma (OSCC). A high TIME score is associated with better prognosis, overexpression of immunotherapy targets, and higher T-cell activity to inhibit tumor growth. The findings suggest that TIME score can serve as a prognostic biomarker and indicator for predicting immunotherapeutic outcomes in OSCC patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Shigeo Ishikawa, Masahiro Sugimoto, Tsuneo Konta, Kenichiro Kitabatake, Shohei Ueda, Kaoru Edamatsu, Naoki Okuyama, Kazuyuki Yusa, Mitsuyoshi Iino
Summary: This study identified salivary 3-methylhistidine as a prognostic factor for overall survival in patients with oral squamous cell carcinoma through comprehensive metabolomic analyses.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gergo Kallo, Petra Magdolna Bertalan, Ildiko Marton, Csongor Kiss, Eva Csosz
Summary: Oral squamous cell carcinoma (OSCC) is associated with microbial infections and/or dysbiosis. OSCC can alter the protein composition of saliva, affecting the chemical barrier function of the oral cavity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Chen, Ziyu Zhu, Qiaoya Pan, Yang Bai, Mengfei Yu, Yi Zhou
Summary: In this study, a novel nanoparticle Co-Fc@HCQ was successfully synthesized, which achieved targeted therapy for oral squamous cell carcinoma by inhibiting autophagy and enhancing the generation of reactive oxygen species.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Minmin Ji, Yuesheng Lv, Chaoqun Chen, Dingya Xing, Chao Zhou, Jinyao Zhao, Yangfan Qi, Jinrui Zhang, Yang Wang, Xiang Ma, Wei Xu, Wenjing Zhang, Xiaojie Li
Summary: This study found that metformin can inhibit the proliferation and migration of oral squamous cell carcinoma by regulating RNA alternative splicing, especially the splicing of the NUBP2 gene, which inhibits cancer cell proliferation.
Article
Oncology
Gerrit Spanier, Ines Ugele, Felix Nieberle, Luisa Symeou, Sandra Schmidhofer, Almut Brand, Johannes Meier, Steffen Spoerl, Rosemarie Krupar, Petra Rummele, Peter Siska, Kathrin Renner, Katrin Peter, Michael Gerken, Philipp Beckhove, Torsten E. Reichert, Marina Kreutz, Katrin Singer
Summary: In patients with oral squamous cell carcinoma, diabetes mellitus type II is associated with abnormal expression of metabolic markers in tumor samples, increased leukocyte infiltration, and elevated CD3(+) T cell numbers, which are crucial for patient outcome. These findings suggest that metabolic differences between diabetic and non-diabetic patients may impact tumor-infiltrating T cells and thus affect patient prognosis.
Article
Oncology
Tsung-You Tsai, Huang-Kai Kao, Yenlin Huang, Ya -Ting Chang, Chi-Kuang Young, Shao-Yu Hung, Yu-Sun Chang, Jau-Song Yu, Kai-Ping Chang
Summary: This study analyzed the association between plasma matrix metalloproteinase-1 (MMP-1) levels and clinicopathological factors as well as survival outcomes in oral cavity squamous cell carcinoma (OSCC). The results showed that plasma MMP-1 levels were significantly associated with the severity and prognosis of OSCC.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Microbiology
Wei Wei, Jia Li, Xin Shen, Jinglu Lyu, Caixia Yan, Boyu Tang, Wenjuan Ma, Huixu Xie, Lei Zhao, Lei Cheng, Ye Deng, Yan Li
Summary: Periodontitis promotes the development of OSCC by altering the oral bacterial community and tumor immune microenvironment.
Article
Dentistry, Oral Surgery & Medicine
Chenguang Zhao, Yingrui Zhou, Hongwei Ma, Jinhui Wang, Haoliang Guo, Hao Liu
Summary: High expression of hypoxia-related genes including ALDOA, P4HA1, PGK1, and VEGFA is associated with poor prognosis in OSCC patients, and they can be used as potential markers for predicting prognosis in OSCC patients.
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Oncology
Ruoyan Cao, Weilin Zhang, Hongjian Zhang, Lixuan Wang, Xijuan Chen, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS in head and neck squamous cell carcinoma (HNSCC). The expression of PRDX1, PRDX4, and PRDX5 in HNSCC is increased, while the expression of PRDX2 is decreased. Higher expression of PRDX4/5/6 indicates poor prognosis, while lower expression of PRDX1/5 is associated with more immune cell infiltration, higher expression of immune-related molecules, and a likely response to anti-PD-1 treatment. Knockdown of PRDX5 inhibits HNSCC cell proliferation, invasion, and metastasis, and promotes apoptosis through its antioxidant property. This study highlights the potential role of PRDXs, particularly PRDX5, in HNSCC and suggests it as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
William J. Benjamin, Kai Wang, Katherine Zarins, Emily Bellile, Freida Blostein, Ilona Argirion, Jeremy M. G. Taylor, Nisha J. D'Silva, Steven B. Chinn, Samara Rifkin, Maureen A. Sartor, Laura S. Rozek
Summary: Further research is needed to determine the impact of the oral microbiome on head and neck cancer, including its pathogenesis and outcomes. This study used 16s rRNA sequencing to analyze oral wash samples from 52 cases and 102 controls. Significant differences were found in the diversity and composition of the oral microbiome between the cases and controls. The presence of specific bacteria associated with periodontitis was more common in the cases, particularly among older patients and smokers.
Article
Biochemistry & Molecular Biology
Yan-Ting Lu, Chung-Yao Hsu, Yo-Tsen Liu, Chung -Kin Chan, Yao-Chung Chuang, Chih-Hsiang Lin, Kai-Ping Chang, Chen-Jui Ho, Ching -Ching Ng, Kheng-Seang Lim, Meng -Han Tsai
Summary: This study aims to delineate the clinical and imaging spectrum that differentiates FLNA-positive and FLNA-negative PVNH patients. The results showed that FLNA mutations accounted for less than half of the PVNH patients, and FLNA-positive patients were more likely to have extra-cerebral features compared with FLNA-negative patients.
BIOMEDICAL JOURNAL
(2022)
Review
Medicine, Research & Experimental
Tsung-You Tsai, Andrea Iandelli, Filippo Marchi, Yenlin Huang, Shiao-Fwu Tai, Shao-Yu Hung, Huang-Kai Kao, Kai-Ping Chang
Summary: In oral squamous cell carcinoma, a higher lymph node burden is significantly associated with worse overall survival, disease-specific survival, and disease-free survival outcomes.
Article
Oncology
Chun-Ta Liao, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Tsang-Wu Liu, Sen-Tien Tsai, Ming-Hsui Tsai, Jin-Ching Lin, Chih-Yen Chien, Pei-Jen Lou, Cheng-Ping Wang, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Tsung-Ming Chen, Cheng-Hsu Wang, Wen-Cheng Chen, Li-Yu Lee, Chien-Yu Lin, Hung-Ming Wang, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang, Tzu-Chen Yen, Lan-Yan Yang, Chih-Hung Lin
Summary: The study found that Taiwanese patients with resected oral cavity squamous cell carcinoma who underwent free flap reconstruction had a higher frequency of clear margins and a significant survival advantage compared to those who received local flaps. Factors such as higher age, advanced tumor staging, greater depth of tumor, and extranodal extension were associated with poorer prognosis for disease-specific survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Wei-Chen Yen, Ian Yi-Feng Chang, Kai-Ping Chang, Chun-Nan Ouyang, Chiao-Rou Liu, Ting-Lin Tsai, Yi-Cheng Zhang, Chun- Wang, Ya-Hui Wang, Alice L. Yu, Hsuan Liu, Chih-Ching Wu, Yu-Sun Chang, Jau-Song Yu, Chia-Yu Yang
Summary: This study provides a comprehensive genomic analysis of OSCC PDXs and identifies high expression of matrix metalloproteinase-1 (MMP1) as a potential biomarker for predicting successful xenografts in OSCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yi-Tung Chen, Chia-Hua Kan, Hsuan Liu, Yu-Hao Liu, Chih-Ching Wu, Yu-Ping Kuo, Ian Yi-Feng Chang, Kai-Ping Chang, Jau-Song Yu, Bertrand Chin-Ming Tan
Summary: Recent findings have highlighted the role of long noncoding RNAs (lncRNAs) in gene regulation, particularly in pathways associated with tumorigenesis. HOXA10-AS, a tumor-biased expressed lncRNA, plays a critical role in oral cancer growth and metastasis and is also associated with drug sensitivity.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Po-Ju Lee, Yun-Hua Sui, Tzu-Tung Liu, Ngan-Ming Tsang, Chen-Han Huang, Ting-Yi Lin, Kai-Ping Chang, Shu-Chen Liu
Summary: The study found that EBV orchestrates interactions with the host and surrounding stroma by stimulating the functions of YAP1 and FAP alpha in fibroblasts through exosome cargos to create a more immunosuppressive, proinvasive microenvironment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ren-Wen Huang, Kai-Ping Chang, Filippo Marchi, Charles Yuen Yung Loh, Yu- Lin, Chee-Jen Chang, Huang-Kai Kao
Summary: This study found that depression is common among patients with head and neck cancer and that depression treatment has a significant impact on their survival outcomes. Patients diagnosed with depression before cancer and who did not receive psychiatric clinic visits after their cancer diagnosis had poorer survival rates. However, in advanced-stage patients, depression treatment may improve overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Pei-Chun Hsueh, Kai-Ping Chang, Hao-Ping Liu, Wei-Fan Chiang, Xiu-Ya Chan, Chu-Mi Hung, Lichieh Julie Chu, Chih-Ching Wu
Summary: This study evaluated the performance of nine salivary autoantibodies as biomarkers for oral cavity squamous cell carcinoma (OSCC). A panel of four autoantibodies achieved high sensitivity and specificity for early diagnosis of OSCC. This multiplex autoantibody platform shows clinical applicability for OSCC screening.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Hao-Wei Chu, Kai-Ping Chang, Wei-Chen Yen, Hao-Ping Liu, Xiu-Ya Chan, Chiao-Rou Liu, Chu-Mi Hung, Chih-Ching Wu
Summary: Oral cavity squamous cell carcinoma (OSCC) is a common fatal illness, and early detection is urgently needed. We identified OSCC-associated autoantibodies using salivary samples and affinity mass spectrometry. Four autoantibodies were significantly increased in early-stage OSCC patients and can serve as potential biomarkers for early diagnosis.
Article
Oncology
Tsung-You Tsai, Huang-Kai Kao, Yenlin Huang, Ya -Ting Chang, Chi-Kuang Young, Shao-Yu Hung, Yu-Sun Chang, Jau-Song Yu, Kai-Ping Chang
Summary: This study analyzed the association between plasma matrix metalloproteinase-1 (MMP-1) levels and clinicopathological factors as well as survival outcomes in oral cavity squamous cell carcinoma (OSCC). The results showed that plasma MMP-1 levels were significantly associated with the severity and prognosis of OSCC.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Chia-Chi Yeh, Huang-Kai Kao, Yenlin Huang, Tsung-You Tsai, Chi-Kuang Young, Shao-Yu Hung, Chuieng-Yi Lu, Kai-Ping Chang
Summary: A newly introduced pan-immune-inflammation value (PIV) was not evaluated for its role in oral cavity squamous cell carcinoma (OSCC). In this study, the PIV was calculated with the following equation (neutrophil count x platelet count x monocyte count)/lymphocyte count from the results of the automated hematology analyzers in 853 OSCC patients from 2005 to 2017. Significant differences were observed for clinicopathological factors between higher and lower PIV patients, and higher PIV was associated with worse overall survival, disease-free survival, locoregional recurrence-free survival, and distant metastasis-free survival. Multivariate analyses demonstrated that PIV was an independent prognostic factor for overall and distant metastasis-free survival.
Article
Oncology
Wei-Chen Yen, Kai-Ping Chang, Cheng-Yi Chen, Yenlin Huang, Ting-Wen Chen, Hsing-Wen Cheng, Jui-Shan Yi, Chun-Chia Cheng, Chih-Ching Wu, Chun- Wang
Summary: By comparing DEGs in OSCC-TCGA patients with CNVs identified in OSCC-OncoScan dataset, we found 37 dysregulated candidate genes, 26 of which have been reported in HNSCC. Among 11 novel candidates, MFI2 was identified as the most significant prognostic molecular in OSCC. Knockdown of MFI2 reduced cell viability, migration, and invasion in OSCC cells through modulation of EGF/FAK signaling.
CANCER CELL INTERNATIONAL
(2023)
Article
Otorhinolaryngology
Yi-Chan Lee, Li-Yu Lee, Yenlin Huang, Huang-Kai Kao, Ya-Ting Chang, Shao-Yu Hung, Chuieng-Yi Lu, Yu-Sun Chang, Jau-Song Yu, Kai-Ping Chang
Summary: This study found that the salivary MMP-1 level is significantly associated with many adverse clinicopathological parameters of OSCC. It has good predictive efficacy in prognosis and is an independent prognostic factor of post-treatment outcome.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
Meeting Abstract
Oncology
Tzu-Tung Liu, Yun-Hua Sui, Fang-Yu Tsai, Shih-Sheng Jiang, Kai-Ping Chang, Chen-Han Huang, Shu-Chen Liu
Article
Oncology
Chia-Hsin Lin, Jiun-Lin Yan, Wing-Keen Yap, Chung-Jan Kang, Yun-Chen Chang, Tsung-You Tsai, Kai-Ping Chang, Chun-Ta Liao, Cheng-Lung Hsu, Wen-Chi Chou, Hung-Ming Wang, Pei-Wei Huang, Kang-Hsing Fan, Bing-Shen Huang, Joseph Tung-Chieh Chang, Shu-Ju Tu, Chien-Yu Lin
Summary: This study investigated the prognostic value of radiomics based on computed tomography (CT) for patients with laryngeal and hypopharyngeal cancer (LHC) during radiotherapy (RT). The results showed that the radiomic models based on peritumoral and intratumoral features during mid-RT had better predictive performance for overall survival (OS) than the models based on pre-RT intratumoral features. The mid-RT radiomic models were also found to be associated with treatment-related lymphopenia.
RADIOTHERAPY AND ONCOLOGY
(2023)
