Review
Oncology
Tian Cheng, Ran Peng, Ang Qu, Hao Wang
Summary: Rectal cancer is a common malignancy that can be effectively treated through high-dose rate endorectal brachytherapy (HDREBT), which delivers high doses of radiation directly to the tumor while sparing normal tissues. This technique has shown promising results in achieving complete remission, nonoperative management, and organ preservation in rectal cancer patients. However, further studies are needed to optimize its effectiveness and long-term impact on survival.
Review
Oncology
Maria Jesus Macias-Lozano, Veronica Diaz-Diaz, Sarah Sayago-Gil, Cayo Garcia-Polo, Javier Jaen-Olasolo
Summary: This retrospective study evaluated the efficacy and toxicity of Iridium-192 high-dose-rate endobronchial brachytherapy (HDR-EBT) for palliation and curative intent in patients with endobronchial lesions. The results showed significant symptomatic relief and endoscopic improvement in palliative and curative settings, with mild and transient toxicity.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Amandeep S. Taggar, Paveen Mann, Michael R. Folkert, Shahdrad Aliakbari, Sten D. Myrehaug, Laura A. Dawson
Summary: HDR ILBT combined with stenting for malignant biliary obstructions and cholangiocarcinoma can prolong stent patency, improve local control, increase partial response rates, and enhance overall survival, with low complication rates and toxicity reported in studies.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Jun Itami, Naoya Murakami, Miho Watanabe, Shuhei Sekii, Takahiro Kasamatsu, Shingo Kato, Hisako Hirowatari, Hitoshi Ikushima, Ken Ando, Tatsuya Ohno, Hiroyuki Okamoto, Kae Okuma, Hiroshi Igaki
Summary: Three-dimensional image-guided brachytherapy has shown significant progress in the treatment of cervical cancer, as the traditional Manchester method cannot deliver an adequate dose. Hybrid brachytherapy, which combines interstitial and intracavitary techniques, has been proven to improve local control rates and can be performed safely and effectively.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zain Siddiqui, Conrad Falkson, Wilma Hopman, Aamer Mahmud
Summary: The purpose of this study was to evaluate the clinical outcomes of endobronchial malignancy treated with high-doserate endobronchial brachytherapy (HDREB). A retrospective chart review showed that most patients experienced improvement in dyspnea, cough, and hemoptysis after treatment, with minimal treatment-related toxicities.
Article
Engineering, Biomedical
Binbing Wang, Weibiao Hu, Guoping Shan, Xiaoxian Xu
Summary: The study investigated high-dose regions of two applicator approaches in brachytherapy, finding that 3D-printed ICBT showed better high-dose region consistency and predictability compared to freehand ISBT.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Oncology
Ioannis Androulakis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo, Gerard C. van Rhoon
Summary: A novel ThermoBrachy applicator has been proposed in this study, allowing for simultaneous radiation and hyperthermia application, resulting in maximum thermal enhancement and efficiency for patient and organization.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Oncology
Hathal Haddad, Horst Hermani, Herbert Hanitzsch, Albert Heidrich, Michael Pinkawa
Summary: This study aimed to compare the dose distributions between permanent low-dose-rate brachytherapy (LDR-BT) and high-dose-rate brachytherapy (HDR-BT), focusing on the impact of a spacer and prostate volume. The results showed that HDR-BT had a more homogeneous dose distribution and lower doses to the urethra compared to LDR-BT. The intraoperative dose at the rectum was considerably lower in HDR-BT patients, especially in smaller prostates. However, prostate volume dose coverage was not improved. These dosimetric results explain the clinical differences reported in the literature.
Article
Oncology
Cristina Gutierrez Miguelez, Rodriguez Rodriguez Villalba, Villafranca Villafranca Iturre, Naiara Fuentemilla Urio, Jose Richart Sancho, Sofia Cordoba Lago, Francisco Pino Sorroche, Garcia Gracia Lucio, Antonio Herreros Martinez, Dina Najjari-Jamal
Summary: This article presents consensus-based recommendations from the Brachytherapy Group of the Spanish Society of Radiation Oncology and the Spanish Society of Medical Physics for interstitial high-dose-rate brachytherapy for gynaecologic malignancies. The recommendations are based on a survey and expert discussions, covering various aspects of the treatment including patient selection, applicator types, and imaging planning. The article provides detailed descriptions of the use of interstitial brachytherapy in the treatment of cervical, vaginal, and vulvar cancers.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Matthew L. Hemming, Shannon Coy, Jia-Ren Lin, Jessica L. Andersen, Joanna Przybyl, Emanuele Mazzola, Amr H. Abdelhamid Ahmed, Matt van de Rijn, Peter K. Sorger, Scott A. Armstrong, George D. Demetri, Sandro Santagata
Summary: This study investigates the impact of differential expression of core and accessory transcription factors on clinical outcomes in GIST, revealing that HAND1 and BARX1 expression can serve as superior predictors of relapse-free survival and predict progression-free survival on imatinib in GIST patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Eric M. Anderson, John David, Tiffany Phillips, John Demarco, Robert S. Reznik, Amin J. Mirhadi, Mitchell Kamrava
Summary: A retrospective study of interstitial high-dose-rate BT treatment of keloids in 14 patients revealed a wide range of target coverage, likely due to the curvature of the skin and challenges in catheter placement. Additional data is needed to evaluate the clinical impact on outcomes/toxicities of dosimetric correlates with single-catheter BT keloid treatment.
Review
Oncology
Efstratios Karagiannis, Iosif Strouthos, Agnes Leczynski, Nikolaos Zamboglou, Konstantinos Ferentinos
Summary: The optimal management of intrahepatic malignancies involves a multidisciplinary approach. In addition to surgical resection, minimally invasive ablative techniques, such as interstitial liver brachytherapy, have become increasingly popular due to their similar oncological results and decreased morbidity. However, despite its flexibility and excellent clinical data, brachytherapy is often not considered as an option in current literature and guidelines.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Vratislav Strnad
Summary: This article discusses the development, current position, and future prospects of gastrointestinal brachytherapy in the past 20 years. In summary, gastrointestinal brachytherapy for different localizations is highly effective and, when performed by experienced professionals, a safe technique that should be incorporated into the armamentarium of radiation oncologists.
Review
Oncology
Zakariya S. Ali, Eden Solomon, Paveen Mann, Shun Wong, Kelvin K. W. Chan, Amandeep S. Taggar
Summary: This article conducts a systematic review on the impact of high dose rate (HDR) brachytherapy (BT) on the clinical outcomes and toxicities of patients with anal cancer. The results show that HDRBT, in combination with external beam radiotherapy (EBRT) and chemotherapy (CT), achieves excellent response, local control, and survival in anal cancer patients, with limited toxicity.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomas Rohan, Tomas Andrasina, Peter Matkulcik, Vladan Bernard, Vlastimil Valek
Summary: This study demonstrates the feasibility and safety of percutaneous endoluminal radiofrequency ablation (eRFA) using a monopolar approach in the recanalization of occluded biliary metal stents.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Oncology
Sujana Gottumukkala, Nhat-Long Pham, Baran Sumer, Larry Myers, John Truelson, Lucien Nedzi, Saad Khan, Randy Hughes, David J. Sher
