Article
Agriculture, Dairy & Animal Science
Guo Yan Wang, Sen Lin Qin, Yi Ning Zheng, Hui Jun Geng, Lei Chen, Jun Hu Yao, Lu Deng
Summary: This study found that propionate enhances the gluconeogenic capacity of calf hepatocytes by regulating the activity of the mTOR pathway, and it counteracts the inhibitory effect of palmitic acid on gluconeogenesis.
Review
Biochemistry & Molecular Biology
Yipin Wang, Nicholas Siu Kay Fung, Wai-Ching Lam, Amy Cheuk Yin Lo
Summary: Recent advances in research have highlighted the importance of the mTOR signaling pathway in the treatment of ocular degenerative diseases. This pathway is regulated by oxidative stress, and understanding the complex relationship between mTOR and oxidative stress is crucial. Additionally, the role of mTOR-mediated autophagy in ocular degenerative diseases should not be overlooked.
Article
Materials Science, Biomaterials
Luxiang Zou, Yingqian Zhong, Xiang Li, Xiujuan Yang, Dongmei He
Summary: This study compared 3D-printed porous titanium (Ti) alloy scaffolds with porous tantalum (Ta) scaffolds for muscle attachment. The results showed that the porous Ta scaffold had better cell proliferation, migration, and adhesion, as well as a higher muscle ingrowth rate and avulsion force compared to the porous Ti alloy scaffold. This suggests that the 3D-printed porous Ta scaffold could be used for clinical applications in muscle attachment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Neurosciences
Henry Querfurth, Han-Kyu Lee
Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.
MOLECULAR NEURODEGENERATION
(2021)
Article
Pharmacology & Pharmacy
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald
Summary: The study demonstrates that mTORC1 and p70S6K are required for reconsolidation of cocaine contextual memory, showing their essential roles in the process through mechanisms such as protein phosphorylation and changes in transcriptional levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yijin Chen, Tong Xu, Mengsha Li, Chuling Li, Yusheng Ma, Guojun Chen, Yili Sun, Hao Zheng, Guangkai Wu, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
Summary: Post-translational modification by SUMO is crucial for cell proliferation and can be reversed by SENPs, providing a potential mechanism for cardiac regeneration. Targeting Akt SUMOylation enhances cardiac regeneration, as seen with SENP2 deficiency leading to CM dedifferentiation and proliferation. Loss of SENP2 increases Akt kinase activity, promoting CM proliferation and angiogenesis through Akt pathway activation, contributing to improved cardiac function post-MI.
Review
Immunology
Soheila Fattahi, Zahra Khalifehzadeh-Esfahani, Mina Mohammad-Rezaei, Sahar Mafi, Morteza Jafarinia
Summary: COVID-19 is a severe respiratory infection caused by SARS-CoV-2 and is a major global challenge. Although several effective COVID-19 vaccines have been developed, our understanding of specific therapeutic drugs for COVID-19 treatment is still limited. The mTOR pathway plays an important role in viral replication, and mTOR pathway inhibitors may be a potential approach to anti-SARS-CoV-2 therapy.
IMMUNOLOGIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Iman F. Abou-El-Naga
Summary: This study examines the signal transduction pathways of Schistosoma mansoni worms and their roles in physiology, suggesting that inhibiting the PI3K/Akt/mTOR signaling pathway could be a promising strategy for controlling schistosomiasis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Review
Immunology
Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Seyed Saeed Tamehri Zadeh, Saeideh Momtaz, Mitra Abbasifard, Zeljko Reiner, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: This critical review examines the critical role of inflammation in various diseases and the potential of statins as inhibitors of the mTOR pathway to regulate inflammation. By collecting data from clinical, in vivo, and in vitro studies, the researchers summarize the beneficial effects of statins on inflammatory diseases.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ana Soriano-Arroquia, John Gostage, Qin Xia, David Bardell, Rachel McCormick, Eugene McCloskey, Ilaria Bellantuono, Peter Clegg, Brian McDonagh, Katarzyna Goljanek-Whysall
Summary: The decline in satellite cell-dependent skeletal muscle regeneration with aging is associated with alterations in miR-24 expression and its target gene Prdx6. Changes in miR-24 levels impact mitochondrial ROS generation, DNA damage pathways, and the viability and myogenic potential of myogenic progenitors, with more pronounced effects observed in old mice. The downregulation of miR-24 and subsequent upregulation of Prdx6 in response to aging may represent an adaptive mechanism to maintain satellite cell function in muscle.
Article
Agriculture, Dairy & Animal Science
Jiahui Xu, Gale M. Strasburg, Kent M. Reed, Sandra G. Velleman
Summary: The growth and development of turkey breast muscle are highly sensitive to temperature, which highlights the importance of temperature management immediately after hatch. Excessive enlargement of muscle fibers can lead to muscle damage and fat deposition in the breast meat, impacting meat quality. This study investigates the cellular mechanisms involved in thermal stress-induced fat synthesis in turkey breast muscle satellite cells, providing valuable insights for the development of temperature manipulation strategies to control fat production and improve poultry meat quality.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Cell Biology
Jiayuan Li, Kuangqi Chen, Xiang Li, Xuhong Zhang, Liyue Zhang, Qianjie Yang, Yutong Xia, Chen Xie, Xiawei Wang, Jianping Tong, Ye Shen
Summary: This review summarizes the changes in the AKT signaling pathway in diabetic retinopathy (DR) and the targeted drugs based on these potential sites.
CELL DEATH DISCOVERY
(2023)
Review
Food Science & Technology
Chenna Di, Wei Jia
Summary: Muscle injury, whether caused by overuse or traumatic distraction, is a common occurrence in sports events of all levels. A review of previous muscle injury data and recovery times for athletes suggests that intervention strategies involving dietary functional factors are crucial for enhancing the recovery process and overall health. There is growing evidence that biologically active peptides, specifically those derived from food proteins, play a significant role in sports nutrition and muscle injury recovery. However, there is limited understanding of the complex histoarchitectural considerations and repair mechanisms of damaged skeletal muscle. This overview provides a summary of potential mechanisms and limitations in skeletal muscle metabolism after injury, highlighting the use of main bioactive peptides and offering implications for future studies on dietary bioactive peptides.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, Research & Experimental
Terry Ting-Yu Chiou, You-Ying Chau, Jin-Bor Chen, Hsiang-Hao Hsu, Shao-Pei Hung, Wen-Chin Lee
Summary: This study investigated the crosstalk between PLA2R activation and mTOR signaling in human podocytes, revealing that inhibiting the PI3K/AKT/mTOR pathway can reduce podocyte apoptosis and suggesting the therapeutic potential of rapamycin in MN treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Weihua Xiao, Yu Liu, Beibei Luo, Linlin Zhao, Xiaoguang Liu, Zhigang Zeng, Peijie Chen
JOURNAL OF SPORT AND HEALTH SCIENCE
(2016)
Article
Physiology
Xiaoguang Liu, Lifang Zhen, Yongzhan Zhou, Yingjie Chen, Peijie Chen, Weihua Xiao
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Physiology
Xiaoguang Liu, Zhigang Zeng, Linlin Zhao, Peijia Chen, Weihua Xiao
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Medicine, Research & Experimental
Lifang Zheng, Xiaoguang Liu, Peijie Chen, Weihua Xiao
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Physiology
Linlin Zhao, Xiaoguang Liu, Jing Zhang, Gaoyang Dong, Weihua Xiao, Xin Xu
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Jian Shou, Xinjuan Shi, Xiaoguang Liu, Yingjie Chen, Peijie Chen, Weihua Xiao
Summary: The research demonstrates that PD-1 can promote contused skeletal muscle regeneration by regulating Treg cell generation and macrophage polarization, providing further insight into the relationship between the immune system and injured skeletal muscle regeneration.
LABORATORY INVESTIGATION
(2021)
Article
Physiology
Jingxin Liu, Lin Zhu, Jing Liao, Xiaoguang Liu
Summary: The study showed that extreme weight loss programs, combining exercise and diet control, resulted in significant improvements in body composition and cardiometabolic health in children with metabolic syndrome. This was associated with changes in plasma metabolites related to lipid metabolism and body composition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Miaomiao Xu, Xiaoguang Liu, Peng Bao, Yan Jie Wang, Jianqiang Lu, Yu Jian Liu
Summary: The study demonstrated that hydrogen sulfide (H2S) has protective effects against immobilization-induced muscle atrophy. Treatment with slow or rapid H2S releasing donors reduced muscle loss, fibrosis, inflammatory response, and oxidative stress, while increasing antioxidant capacity in skeletal muscles.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoguang Liu, Miaomiao Xu, Yang Yu, Yingjie Chen, Xinyu Weng, Lin Zhu
Summary: PD-1 plays an important role in cisplatin-induced skeletal muscle atrophy, with PD-1 knockout exacerbating muscle wasting and influencing inflammation and oxidative stress in muscles.
Article
Biochemistry & Molecular Biology
Miaomiao Xu, Xiaoguang Liu, Peng Bao, Yanjie Wang, Xiaoyan Zhu, Yujian Liu, Xin Ni, Jianqiang Lu
Summary: Cystathionine-gamma-lyase (CSE) plays a critical role in skeletal muscle by regulating multiple signaling pathways involved in insulin sensitivity and glucose metabolism.