Article
Biochemistry & Molecular Biology
Ran Wei, Zhucheng Su, Gerardo G. Mackenzie
Summary: This study evaluated the gut protecting effect of CGA and EGCG, major constituents of coffee and green tea, on d-galactose-induced aging mice. CGA plus EGCG improved cognition deficits and protected gut barrier function more effectively compared to the agents alone. Additionally, CGA and EGCG modulated the gut microbiome and reduced gut inflammation.
Article
Geriatrics & Gerontology
Min-Huang Hsieh, Zhen-Yang Cui, Ai-Lun Yang, Nguyen Thanh Nhu, Shih-Ying Ting, Shao-Hong Yu, Yu-Jung Cheng, Yi-Yuan Lin, Xu-Bo Wu, Shin-Da Lee
Summary: The green tea flavonoid epigallocatechin-3-gallate (EGCG) may prevent neural apoptotic pathways and activate neural survival pathways in early aged hypertension-induced neural apoptosis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Article
Biochemistry & Molecular Biology
Shih-Chung Huang, Yung-Hsi Kao, Shao-Fu Shih, Min-Chien Tsai, Chin-Sheng Lin, Liv Weichien Chen, Yi-Ping Chuang, Pi-Fen Tsui, Ling-Jun Ho, Jenn-Haung Lai, Sy-Jou Chen
Summary: EGCG can suppress cytokine secretion in activated human primary T cells, likely mediated by AP-1 inactivation through the ERK and JNK pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anatomy & Morphology
Amir Raoofi, Melody Omraninava, Roghayeh Javan, Davood Maghsodi, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi
Summary: Chronic scrotal hyperthermia (SHT) can lead to serious male reproductive system disorders, mainly due to oxidative stress. Epigallocatechin gallate (EGCG) as a potent antioxidant can alleviate cellular and tissue damage caused by SHT. EGCG improves sperm parameters, testosterone levels, and reduces cellular apoptosis and oxidative stress.
Review
Biochemistry & Molecular Biology
Daniela Mokra, Marta Joskova, Juraj Mokry
Summary: (
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Biotechnology & Applied Microbiology
Yiming Wang, Wenqi Luo, Feng Lin, Wanguo Liu, Rui Gu
Summary: EGCG-Se NP shows superior neuroprotective effect in spinal cord injury (SCI) through scavenging reactive oxygen species (ROS) and attenuating inflammation, making it a promising and effective treatment option.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Kangfa Huang, Chengde Li, Fenglei Gao, Yushan Fan, Fanwen Zeng, Li Meng, Li Li, Shouquan Zhang, Hengxi Wei
Summary: The study demonstrated that EGCG promotes the in vitro maturation and embryo development following IVF of porcine oocytes. The protective effects of EGCG on the oocytes may be associated with its antioxidant and anti-apoptosis properties.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Santino Blando, Sabrina Valente, Fulvia Farabegoli, Maria Letizia Focarete, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: This study demonstrates the involvement of migration and osteogenic genes in human umbilical vein endothelial cells (HUVEC) cultured with a poly-L-lactic acid (PLLA) electrospun mat. Additionally, epigallocatechin-3-gallate (EGCG) was found to inhibit HUVEC migration and osteogenic differentiation, and mitigate the effects of PLLA on gene expression. EGCG also affected peripheral blood mononuclear cell (PBMC) proliferation and migration in a transwell co-culture system with HUVEC and PLLA.
Review
Biochemistry & Molecular Biology
Ashley Payne, Samuel Nahashon, Equar Taka, Getinet M. Adinew, Karam F. A. Soliman
Summary: Alzheimer's and Parkinson's diseases are common neurodegenerative diseases with complex etiology involving environmental, molecular, and genetic factors. This review focuses on the neuroinflammatory and neuroprotective role of EGCG, a medicinal component of green tea, which has antioxidant, anti-inflammatory, and anti-aging abilities. It shows promise in modulating AD progression and offers innovative approaches for prevention of AD and other neurodegenerative disorders.
Article
Pharmacology & Pharmacy
Amirah Abdul Rahman, Wan Zurinah Wan Ngah, Rahman Jamal, Suzana Makpol, Roslan Harun, Norfilza Mokhtar
Summary: Therapeutic potential of hydroxychavicol (HC) and epigallocatechin-3-gallate (EGCG) against cancer cells has been reported, but high concentrations are required. In this study, low combination doses of EGCG+HC were found to have a synergistic effect in inhibiting the growth of glioma cells. The treatment also induced cell death and arrested the cell cycle at S phase. The combination therapy altered the expression of specific genes and pathways involved in tumor progression. This research provides valuable insights for the development of glioma cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2022)