Chrousos syndrome: from molecular pathogenesis to therapeutic management

Stress, the Stress System and the Role of Glucocorticoids

(2015) Nicolas C. Nicolaides et al.   NEUROIMMUNOMODULATION

Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and its actions

(2014) Nicolas C. Nicolaides et al.   Annals of the New York Academy of Sciences

Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN

(2014) Lance A. Stechschulte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Point Mutation of the Human Glucocorticoid Receptor Gene Causes Primary Generalized Glucocorticoid Resistance Through Impaired Interaction With the LXXLL Motif of the p160 Coactivators: Dissociation of the Transactivating and Transreppressive Activities

(2014) Nicolas C. Nicolaides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenal insufficiency

(2014) Evangelia Charmandari et al.   LANCET

Glucocorticoid Receptor β Acts as a Co-activator of T-Cell Factor 4 and Enhances Glioma Cell Proliferation

(2014) Qian Wang et al.   MOLECULAR NEUROBIOLOGY

Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor

(2014) Nicolas C Nicolaides et al.   BMC Endocrine Disorders

A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its DBD

(2013) Michael L. Roberts et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ligand-Induced Repression of the Glucocorticoid Receptor Gene Is Mediated by an NCoR1 Repression Complex Formed by Long-Range Chromatin Interactions with Intragenic Glucocorticoid Response Elements

(2013) Sivapriya Ramamoorthy et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucocorticoid sensitivity in health and disease

(2013) Rogier A. Quax et al.   Nature Reviews Endocrinology

Glucocorticoid receptor β regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/TCF transcriptional activity

(2013) Ying Yin et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways

(2012) Emira Ayroldi et al.   FASEB JOURNAL

The neuroendocrine control of the innate immune system in health and brain diseases

(2012) Marc-André Bellavance et al.   IMMUNOLOGICAL REVIEWS

Non-genomic effect of glucocorticoids on cardiovascular system

(2012) Sung Ryul Lee et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Primary Generalized Glucocorticoid Resistance and Hypersensitivity: The End-Organ Involvement in the Stress Response

(2012) E. Charmandari   Science Signaling

Q&A: Primary generalized glucocorticoid resistance

(2011) George Chrousos   BMC Medicine

Primary Generalized Glucocorticoid Resistance and Hypersensitivity

(2011) Evangelia Charmandari   Hormone Research in Paediatrics

Cell Cycle Phase Regulates Glucocorticoid Receptor Function

(2011) Laura Matthews et al.   PLoS One

Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes

(2010) Evangelia Charmandari et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids

(2010) Robert H. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain

(2010) Nancy Nader et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucocorticoid receptor (GR) β has intrinsic, GRα-independent transcriptional activity

(2009) Tomoshige Kino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human glucocorticoid receptor isoform β: recent understanding of its potential implications in physiology and pathophysiology

(2009) Tomoshige Kino et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neonatal Complete Generalized Glucocorticoid Resistance and Growth Hormone Deficiency Caused by a Novel Homozygous Mutation in Helix 12 of the Ligand Binding Domain of the Glucocorticoid Receptor Gene (NR3C1)

(2009) Sarah K. McMahon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

The human glucocorticoid receptor: Molecular basis of biologic function

(2009) Nicolas C. Nicolaides et al.   STEROIDS

Generalized Glucocorticoid Resistance: Clinical Aspects, Molecular Mechanisms, and Implications of a Rare Genetic Disorder

(2008) Evangelia Charmandari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM