Article
Neurosciences
Qian Zhang, Wei Song, Bingjia Zhao, Jun Xie, Qing Sun, Xiaohu Shi, Bin Yan, Guoqing Tian, Xiaochun Liang
Summary: The study revealed that quercetin has a neuroprotective effect in diabetic peripheral neuropathy by activating the AMPK/PGC-1 alpha pathway, promoting mitochondrial protection, and improving neurodegenerative changes. It also corrected oxidative stress, decreased ATP generation, and mitochondrial morphological changes, showing potential as a therapeutic agent in diabetic neuropathy management.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Ding Ding, Jie Zhang, Baozhen Du, Xuanzhao Wang, Li Hou, Siyuan Guo, Bing Chen, Le Kang
Summary: This study reveals that Hif-1 alpha 2 plays a critical regulatory role in locust flight, instead of inducing typical hypoxic responses. Hif-1 alpha 2 maintains redox homeostasis during flight by modulating physiological processes such as glucose metabolism and antioxidation, thus supporting prolonged aerobic activity.
Article
Biochemistry & Molecular Biology
Jing Peng, Zhen Yang, Hao Li, Baocheng Hao, Dongan Cui, Ruofeng Shang, Yanan Lv, Yu Liu, Wanxia Pu, Hongjuan Zhang, Jiongjie He, Xuehong Wang, Shengyi Wang
Summary: The redox system is closely related to changes in cellular metabolism. Quercetin, a flavonoid compound, has been found to have anti-inflammatory and antioxidant activities. In this study, it was investigated whether quercetin can inhibit LPS-induced oxidative stress in inflammatory macrophages by affecting immunometabolism. The results showed that quercetin improved the antioxidant enzyme activity, inhibited reactive oxygen species (ROS) production, and decreased the expression of pro-inflammatory factors in inflammatory macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jianbo Wu, Shelly Gulati, April M. M. Teague, Youngsil Kim, Jeanie B. B. Tryggestad, Shaoning Jiang
Summary: Adverse intrauterine environments can cause epigenetic changes in stem cells, increasing the risk of metabolic diseases in offspring. This study found that pharmaceutical activation of AMPK can restore the epigenetic landscape and function of Wharton's Jelly mesenchymal stem cells (WJ-MSCs) from women with diabetes during pregnancy. Activation of AMPK decreases PGC-1α promoter methylation, increases PGC-1α expression, and enhances mitochondrial biogenesis and myogenic differentiation in WJ-MSCs.
STEM CELLS AND DEVELOPMENT
(2023)
Article
Cell Biology
Sophia Bam, Erin Buchanan, Caitlyn Mahony, Colleen O'Ryan
Summary: In this study, researchers investigated DNA methylation patterns at key genes involved in mitochondrial homeostasis in South African children with ASD. The results showed differential methylation at these genes, particularly PGC-1α, which was associated with elevated mtDNA copy number and metabolomic evidence of mitochondrial dysfunction in ASD. This study highlights the role of DNA methylation in regulating specific pathways involved in mitochondria' biogenesis, fission and fusion contributing to mitochondrial dysfunction in ASD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haruka Takagi, Isao Tamura, Taishi Fujimura, Yumiko Doi-Tanaka, Yuichiro Shirafuta, Yumiko Mihara, Ryo Maekawa, Toshiaki Taketani, Shun Sato, Hiroshi Tamura, Norihiro Sugino
Summary: PGC-1α is upregulated by C/EBPβ recruitment to novel enhancers, forming a histone-modifying complex with C/EBPβ and p300, thereby inducing epigenomic changes in the promoters and enhancers of IGFBP-1 and PRL, contributing to decidualization.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jun Wang, Kwang-Su Park, Xufen Yu, Weida Gong, H. Shelton Earp, Gang Greg Wang, Jian Jin, Ling Cai
Summary: This study reveals the non-canonical (co-)activator recruitment and gene activation functions of EZH2 in prostate cancer and suggests that EZH2-targeting PROTACs could be a potential therapeutic approach for aggressive prostate cancer.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Neurosciences
Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski
Summary: This study aimed to determine whether driver mutation variant allelic frequency (VAF) could serve as an objective metric for cellularity in MGMT promoter methylation testing and identify possible false-negative samples. The results showed that microscopic examination tended to overestimate tumor cellularity when VAF was low, and re-testing low-VAF cases using methylation array and droplet digital PCR (ddPCR) confirmed the presence of false-negative cases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Rataya Tanomrat, Chonnapat Naktubtim, Parichaya Aimvijarn, Prasit Suwannalert
Summary: This study aimed to evaluate the improvement effect of quercetin in combination with NAC in human CRC cell progression, migration, and invasion. The results revealed that the combination treatment was most effective in decreasing cellular oxidants, increasing glutathione levels, suppressing cancer cell migration and invasion, and inhibiting the expression of iNOS, ICAM-1, and MMP-2 proteins. Bioinformatic analysis further confirmed the association of these proteins with poor prognosis in CRC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Chemistry, Applied
Krishnan Abinaya, Kumar Sharmila, Santhanvelayudham Priya, Marimuthu Ponmozhi, Radhakrishnan Linekha
Summary: An antioxidant-rich red onion gummy jelly (ROGJ) was developed in this study by transforming the pungent taste of red onion using tamarind. The gummy samples met the required physicochemical properties, texture properties, and color values. The antioxidant activity analysis showed that the ROGJ had potential antioxidant activity and could be commercialized as a healthy substitute for commercial unhealthy gummy jellies.
FOOD HYDROCOLLOIDS FOR HEALTH
(2023)
Article
Allergy
Maria Kostara, Vasiliki Chondrou, Vassilis Fotopoulos, Argyro Sgourou, Sophia Tsabouri
Summary: This study investigates the influence of certain genetic regions on the development of food allergy and finds that DNA methylation and genetic polymorphisms in the HLA-G gene region are closely associated with the development of food allergy.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Jun Nishihira, Mie Nishimura, Masanori Kurimoto, Hiroyo Kagami-Katsuyama, Hiroki Hattori, Toshiyuki Nakagawa, Takato Muro, Masuko Kobori
Summary: A clinical trial showed that continuous intake of quercetin-rich onion can reduce age-related cognitive decline, possibly by improving emotional conditions to prevent cognitive decline.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Review
Oncology
Richard J. Epstein, Li Jun Tian, Yan Fei Gu
Summary: More than ten thousand studies have evaluated the role of FGFs and FGFRs in cancer, with a focus on the complex splicing events of FGFR2 and its isoforms. The ability of FGFR2 to switch between tumor-suppressing and -driving functions based on splicing highlights the need for more specific and precise targeting strategies in cancer treatment.
JOURNAL OF ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohammed A. Al-Obaide, Ibtisam L. I. Al-Obaidi, Tetyana L. Vasylyeva
Summary: This study suggests that DNA methylation of the GLA-HNRNPH2 bidirectional promoter may be involved in the diagnosis and treatment of Fabry disease.
BIOMEDICAL REPORTS
(2022)
Article
Endocrinology & Metabolism
Sudip Bajpeyi, Jeffrey D. Covington, Erin M. Taylor, Laura K. Stewart, Jose E. Galgani, Tara M. Henagan
Review
Biochemistry & Molecular Biology
Prasad P. Devarshi, Sean M. McNabney, Tara M. Henagan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Laura A. Forney, Natalie R. Lenard, Laura K. Stewart, Tara M. Henagan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Nutrition & Dietetics
Prasad P. Devarshi, Ryan W. Grant, Chioma J. Ikonte, Susan Hazels Mitmesser
Review
Nutrition & Dietetics
Carroll A. Reider, Ray-Yuan Chung, Prasad P. Devarshi, Ryan W. Grant, Susan Hazels Mitmesser
Article
Nutrition & Dietetics
Prasad P. Devarshi, LeeCole L. Legette, Ryan W. Grant, Susan Hazels Mitmesser
Summary: The study found that many women of childbearing age and menopausal age do not meet recommended nutrient intakes for multiple nutrients, while the use of supplements helps fill some nutrient gaps. Dietary intake is positively associated with most nutrient status biomarkers.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Rachel A. Murphy, Prasad P. Devarshi, Shauna Ekimura, Keri Marshall, Susan Hazels Mitmesser
Summary: This study aimed to determine the reference ranges of circulating long-chain (LC) omega-3 fatty acids in a nationally representative population of Americans. The findings indicated that the majority of children and a portion of adults had lower LC omega-3 concentrations than recommended levels, highlighting the importance of emphasizing regular consumption of LC omega-3s among Americans.
Article
Endocrinology & Metabolism
Prasad P. Devarshi, Andrea S. Pereyra, Jessica M. Ellis, Tara M. Henagan
Summary: The aim of this study was to compare the molecular and metabolic effects of a single exercise bout in the skeletal muscle between lean and overweight/obese individuals. The results showed that a single exercise bout improved blood metabolite profiles, increased mRNA abundance of genes related to mitochondria and insulin signaling in both lean and overweight/obese participants. Additionally, exercise induced epigenetic alterations in skeletal muscle in a BMI-independent manner.
DIABETES OBESITY & METABOLISM
(2022)
Article
Clinical Neurology
Rachel A. Murphy, Prasad P. Devarshi, Jonathan G. Mun, Keri Marshall, Susan Hazels Mitmesser
Summary: The study found associations between serum long-chain (LC) omega-3 fatty acid levels and sleep parameters, with differences observed in omega-3 levels among individuals with short sleep duration. Further interventions are needed to clarify causality in this relationship.
Article
Nutrition & Dietetics
Rachel Murphy, Keri Marshall, Sandra Zagorin, Prasad P. Devarshi, Susan Hazels Mitmesser
Summary: Adequate consumption of nutrients supporting infant neurodevelopment is crucial for pregnant women and women of childbearing age. Socioeconomic inequalities have a significant impact on nutrient intake, particularly among those experiencing such inequalities. Dietary supplements can help mitigate nutritional shortfalls.
Meeting Abstract
Obstetrics & Gynecology
LeeCole Legette, Prasad Devarshi, Kelly Higgins, Ryan Grant, Susan Hazels Mitmesser
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Prasad P. Devarshi, Aarin D. Jones, Erin M. Taylor, Tara M. Henagan
Meeting Abstract
Biochemistry & Molecular Biology
Prasad P. Devarshi, Aarin D. Jones, Erin M. Taylor, Tara M. Henagan