Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 25, Issue 6, Pages 921-926Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2017.02.004
Keywords
Curcumin; Cellulose acetate phthalate; Nanofiber; In vitro; Transdermal
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Funding
- Hanseo University
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning, South Korea [2014-004694]
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Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its in vitro CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and in vitro diffusion studies. The as-prepared fibers demonstrated controlled in vitro transdermal delivery of CUR for up to 24 h. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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