Article
Multidisciplinary Sciences
Hannah von Mersi, Thomas Benkoe, Heidrun Boztug, Michael Dworzak, Gernot Engstler, Waltraud Friesenbichler, Caroline Hutter, Karoly Lakatos, Georg Mann, Martin Metzelder, Roswitha Lueftinger, Herbert Pichler, Fiona Poyer, Leila Ronceray, Andishe Attarbaschi
Summary: Acute appendicitis is a rare but usually non-life-threatening complication in pediatric hemato-oncologic patients. Prompt administration of broad-spectrum antibiotics and delayed appendectomy can safely manage the condition in most cases.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Jorge Kassisse L, Luis Delpiano M, Francia Lopez D, Anibal Espinoza G
Summary: Neutropenic enterocolitis (NEC) is a gastrointestinal disease that can cause severe and life-threatening conditions in immunocompromised patients, especially in childhood cancer. The exact pathology of NEC is unclear, but it is known to be multifactorial, involving the cytotoxic effects of chemotherapy drugs and gastrointestinal injuries that lead to symptoms such as abdominal pain.
REVISTA CHILENA DE INFECTOLOGIA
(2022)
Review
Infectious Diseases
Jessica E. Morgan, Bob Phillips, Gabrielle M. Haeusler, Julia C. Chisholm
Summary: Febrile neutropenia (FN) is a common complication of cancer treatment in children, requiring risk stratification, optimal antimicrobial selection, and timely treatment. The focus is on improving patient experience and reducing infection risk.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Oncology
Zi Lin Lim, Peh Joo Ho, Mikael Hartman, Ern Yu Tan, Nur Khaliesah Binte Mohamed Riza, Elaine Hsuen Lim, Phyu Nitar, Jingmei Joint Breast Cancer Registry (JBCR), Fuh Yong Wong, Jingmei Li
Summary: This two-part study found that non-Chinese ethnicity is associated with a higher incidence of febrile neutropenia (FN) in chemotherapy-treated breast cancer patients. Indian patients had a greater decrease in absolute neutrophil count during chemotherapy, while Malay patients were more likely to receive anthracycline treatment, both contributing to higher FN risk. Non-Chinese patients were also more likely to experience multiple FN episodes. Further research is needed to investigate pharmacogenetic differences across ethnicities.
Article
Microbiology
Maria Bachlitzanaki, George Aletras, Eirini Bachlitzanaki, Ippokratis Messaritakis, Stergos Koukias, Asimina Koulouridi, Emmanouil Bachlitzanakis, Eleni Kaloeidi, Elena Vakonaki, Emmanouil Kontopodis, Nikolaos Androulakis, Georgios Chamilos, Dimitrios Mavroudis, Petros Ioannou, Diamantis Kofteridis
Summary: Febrile neutropenia is a common and serious complication in cancer patients, and this study aimed to investigate the epidemiological and microbiological characteristics of hospitalized patients with solid tumors and neutropenia, as well as factors influencing patient outcomes.
Review
Hematology
Natacha Kapandji, Elie Azoulay, Lara Zafrani
Summary: This review provides insights into the clinical entity, diagnostic and therapeutic management of neutropenic enterocolitis (NE), and hypotheses on pathophysiology for further research.
Article
Oncology
Jiyoung Keum, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang
Summary: This study aimed to investigate the association between UGT1A1 polymorphisms and FOLFIRINOX-induced neutropenia. The results showed that female sex, ECOG PS = 1, UGT1A1 IM, and UGT1A1 PM were independent risk factors for FN. It is recommended to screen UGT1A1 before chemotherapy.
Article
Oncology
Sophie Peltekian, Shellyza Sajwani, Xiang Wang, Salmaan Kanji
Summary: The purpose of this study was to determine the incidence of febrile neutropenia (FN) and neutropenia in patients with castrate-resistant metastatic prostate cancer (mCRPC) receiving docetaxel and to identify predictors for FN. The results showed that the incidence of FN and neutropenia in patients receiving docetaxel for mCRPC was 25% and 33% respectively. Age and multiple comorbidities were identified as risk factors for FN.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Veterinary Sciences
Gayathriy Balamayooran, Hannah M. M. Atkins, Rachel N. N. Andrews, Kristofer T. T. Michalson, A. Robert Hutchison, Andre C. C. LeGrande, Quentin N. N. Wilson, Melaney K. K. Gee, S. Tyler Aycock, Matthew J. J. Jorgensen, Richard W. W. Young, Nancy D. D. Kock, David L. L. Caudell
Summary: Yersinia enterocolitica is a Gram-negative bacterium that causes enterocolitis in humans and poses significant risks to public health worldwide. An outbreak of Yersinia infection in the vervet monkey colony resulted in systemic infection with high morbidity and mortality. The study found immunocompromised state in affected animals, with increased myeloid-derived phagocytes and antigen-presenting cells and decreased T and B lymphocytes. Further studies in vervets could provide insights into Yersinia pathogenesis and immunosuppression in humans.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pediatrics
Niti Shahi, Alexander Kaizer, Jenny Stevens, Ryan Phillips, Shannon N. Acker, Young Mee Choi, Gabrielle Shirek, Denis Bensard, Jennifer Bruny, Kimberly Dannull, Steven L. Moulton
Summary: This study investigates the application of imaging and physiological indicators associated with surgical intervention and mortality in patients with neutropenic enterocolitis. The study found that elevated SIPA is associated with increased mortality, and specific CT findings are related to surgical intervention.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Victoria Probst, Lotte Moller Smedegaard, Arman Simonyan, Yuliu Guo, Olga Ostrup, Kia Hee Schultz Dungu, Nadja Hawwa Vissing, Ulrikka Nygaard, Frederik Otzen Bagger
Summary: Improved methods are needed to diagnose infectious diseases in children with cancer. Recent research has shown that host whole blood RNA transcriptomic signatures can distinguish bacterial infection from other causes of fever. In this study, a low-input protocol was successfully used to sequence samples from children with leukemia and suspected infection, which could provide a solution to the challenge of obtaining sufficient RNA from patients with low white blood cell counts. Further studies are required to validate the immune gene signatures captured and determine their clinical usefulness as a diagnostic tool for cancer patients with suspected infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Ying Wang, Zhichao Du, Yongdong Chen, Yugang Liu, Zhitang Yang
Summary: The meta-analysis indicated that for empirical treatment of cancer patients with febrile neutropenia, ceftazidime plus amikacin was more effective than meropenem, but had more adverse effects. The treatment effects of the two methods were almost parallel in adults.
Review
Hematology
Marcio Nucci
Summary: The management of febrile neutropenia in patients with hematologic malignancies has evolved over the past decades, with key topics including prophylaxis, initial workup for fever, choice of antibiotic regimen, and criteria for discontinuation. This article reviews the author's approach to evaluating and treating these patients by discussing relevant literature and providing personal perspective.
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Emergency Medicine
Max Ackerman, Arian Frost, Kimberly Stanford
Summary: We report a case of neutropenic enterocolitis in a patient with HIV who was not neutropenic on presentation. The patient was diagnosed with NE based on CT scan findings and was promptly treated with broad-spectrum antibiotics.
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Oncology
Bernardo Leon Rapoport, Marcial Garcia-Morillo, Carme Font, Zarka Samoon, Adnan Abdul Jabbar, Hampig Raphael Kourie, Aline Kayumba, Francis Esposito, Razvan Andrei Popescu, Jesus Garcia-Gomez, Liezl Heyman, Teresa Smit, Andriy Krendyukov, Nicola Mathieson, Tim Cooksley, Ronald Anderson, Jean Klastersky
Summary: This study aimed to investigate the incidence of febrile neutropenia (FN) in intermediate-risk patients and assess the rationale for using granulocyte colony-stimulating factor (G-CSF) in these patients. The results showed a low incidence of FN in clinical practice, with a decreasing trend in subsequent chemotherapy cycles.
SUPPORTIVE CARE IN CANCER
(2023)