Innovative Clinical Trial Designs for Precision Medicine in Heart Failure with Preserved Ejection Fraction

Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study

(2017) Burkert Pieske et al.   EUROPEAN HEART JOURNAL

Text Mining of the Electronic Health Record: An Information Extraction Approach for Automated Identification and Subphenotyping of HFpEF Patients for Clinical Trials

(2017) Siddhartha R. Jonnalagadda et al.   Journal of Cardiovascular Translational Research

Precision Medicine for Heart Failure with Preserved Ejection Fraction: An Overview

(2017) Sanjiv J. Shah   Journal of Cardiovascular Translational Research

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure

(2016) Ted Feldman et al.   Circulation-Heart Failure

Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy

(2016) Iacopo Olivotto et al.   Circulation-Heart Failure

PIPELINEs: Creating Comparable Clinical Knowledge Efficiently by Linking Trial Platforms

(2016) MR Trusheim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Microvascular endothelial dysfunction in heart failure with preserved ejection fraction

(2016) Carolyn S P Lam et al.   HEART

The HFpEF Obesity Phenotype

(2016) Dalane W. Kitzman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mastering the game of Go with deep neural networks and tree search

(2016) David Silver et al.   NATURE

Adaptive Designs for Clinical Trials

(2016) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pragmatic Trials

(2016) Ian Ford et al.   NEW ENGLAND JOURNAL OF MEDICINE

Growing Evidence Linking Microvascular Dysfunction With Heart Failure With Preserved Ejection Fraction

(2016) Gregory Giamouzis et al.   Journal of the American Heart Association

How to Develop and Implement a Specialized Heart Failure with Preserved Ejection Fraction Clinical Program

(2016) Sanjiv J. Shah et al.   Current Cardiology Reports

Statistical controversies in clinical research: scientific and ethical problems with adaptive randomization in comparative clinical trials

(2015) P. Thall et al.   ANNALS OF ONCOLOGY

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Machine Learning in Medicine

(2015) R. C. Deo   CIRCULATION

Cardiac endothelium–myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction

(2015) Shir Lynn Lim et al.   EUROPEAN HEART JOURNAL

Lorcaserin Hcl for the treatment of obesity

(2015) Alpana P Shukla et al.   EXPERT OPINION ON PHARMACOTHERAPY

Patient-centric trials for therapeutic development in precision oncology

(2015) Andrew V. Biankin et al.   NATURE

Human-level control through deep reinforcement learning

(2015) Volodymyr Mnih et al.   NATURE

The Challenges of Precision Oncology Drug Development and Implementation

(2015) Simon J. Hollingsworth et al.   Public Health Genomics

Three simple rules to ensure reasonably credible subgroup analyses

(2015) James F Burke et al.   BMJ-British Medical Journal

Three simple rules to ensure reasonably credible subgroup analyses

(2015) James F Burke et al.   BMJ-British Medical Journal

Wireless Pulmonary Artery Pressure Monitoring Guides Management to Reduce Decompensation in Heart Failure With Preserved Ejection Fraction

(2014) Philip B. Adamson et al.   Circulation-Heart Failure

New Strategies in Personalized Medicine for Solid Tumors: Molecular Markers and Clinical Trial Designs

(2014) J. M. Jurgensmeier et al.   CLINICAL CANCER RESEARCH

New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes

(2014) M. Senni et al.   EUROPEAN HEART JOURNAL

Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)

(2014) Burkert Pieske et al.   EUROPEAN JOURNAL OF HEART FAILURE

The pathophysiology of heart failure with preserved ejection fraction

(2014) Barry A. Borlaug   Nature Reviews Cardiology

Spironolactone for Heart Failure with Preserved Ejection Fraction

(2014) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic Spectrum of Heart Failure with Preserved Ejection Fraction

(2014) Sanjiv J. Shah et al.   Heart Failure Clinics

Developing Therapies for Heart Failure With Preserved Ejection Fraction

(2014) Javed Butler et al.   JACC-Heart Failure

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs

(2013) Herbert Y. Meltzer et al.   JOURNAL OF CLINICAL INVESTIGATION

Matchmaking for the Optimization of Clinical Trials of Heart Failure With Preserved Ejection Fraction

(2013) Sanjiv J. Shah   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

Reinforcement Learning Strategies for Clinical Trials in Nonsmall Cell Lung Cancer

(2011) Yufan Zhao et al.   BIOMETRICS

Systemic sclerosis and the heart

(2011) Chintan S. Desai et al.   CURRENT OPINION IN RHEUMATOLOGY

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

(2010) B. A. Borlaug et al.   EUROPEAN HEART JOURNAL

Perspectives on the Use of Adaptive Designs in Clinical Trials. Part I. Statistical Considerations and Issues

(2010) Sue-Jane Wang   Journal of Biopharmaceutical Statistics

Seamless phase II/III designs

(2010) Nigel Stallard et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Reinforcement learning design for cancer clinical trials

(2009) Yufan Zhao et al.   STATISTICS IN MEDICINE

Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction

(2008) Barry M. Massie et al.   NEW ENGLAND JOURNAL OF MEDICINE