Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis

(2016) Wei Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The thioredoxin system in breast cancer cell invasion and migration

(2016) Maneet Bhatia et al.   Redox Biology

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

(2016) E. Doka et al.   Science Advances

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

(2015) Prahlad V. Raninga et al.   Oncotarget

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

(2015) Ningning Liu et al.   Oncotarget

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

(2014) W. Fiskus et al.   CANCER RESEARCH

Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

(2014) C Fan et al.   Cell Death & Disease

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

(2014) S Watanabe et al.   Cell Death & Disease

Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity

(2013) J-T Kim et al.   Cell Death & Disease

Overexpression of Cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma

(2013) You-Fang Chen et al.   BMC Surgery

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The multiple roles of autophagy in cancer

(2011) M. T. Rosenfeldt et al.   CARCINOGENESIS

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

(2010) Belen Tizon et al.   PLoS One

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

(2009) Valentina Gandin et al.   BIOCHEMICAL PHARMACOLOGY

Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer

(2009) Eun Hwa Choi et al.   CLINICA CHIMICA ACTA

Cystatins and cancer

(2009) James et al.   Frontiers in Bioscience-Landmark

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

(2008) Sharon A Tooze et al.   CURRENT OPINION IN NEUROBIOLOGY