Article
Multidisciplinary Sciences
Alexander J. Moorhouse, Amy E. Loats, Kathryn F. Medler, Stefan G. E. Roberts
Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Removal of active histone modifications H3K9ac and H3K4me3 by BASP1 requires N-terminal myristoylation, while placement of the repressive histone modification H3K27me3 does not require lipidation. BASP1 regulates activity of multiple transcription factors and induces extensive changes in chromatin accessibility, with about 50% of BASP1 target genes showing lipidation-dependent chromatin compaction and transcriptional repression.
Review
Biochemistry & Molecular Biology
Prarthana Gopinath, Revathi Paramasivam Oviya, Gopal Gopisetty
Summary: Estrogen plays a significant role in tumorigenesis, but some breast cancer patients develop resistance to estrogen. Non-classical estrogen signaling through various pathways is important in cancer development and clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jyotsna Pardeshi, Niamh McCormack, Lili Gu, Cathal S. Ryan, Martina Schroder
Summary: This study reveals a novel physical interaction between DDX3X and ERα, which positively regulates ERα activation. Knockdown of DDX3X reduces ERα phosphorylation, expression of target genes, and cell proliferation, while overexpression of DDX3X enhances ERα phosphorylation and activity. These findings suggest an important role of DDX3X in breast cancer development and resistance to endocrine therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Oncology
YaLing Li, YaLi Gao, XueLi Niu, MingSui Tang, JingYi Li, Bing Song, XiuHao Guan
Summary: The study identified the long noncoding RNA BASP1-AS1 as crucial for the development and prognosis of melanoma. A four-gene prognostic model was constructed and BASP1-AS1 was found to promote cell proliferation, migration, and invasion in melanoma cells. Additionally, BASP1-AS1 was shown to interact with YBX1 and regulate the Notch signaling pathway, contributing to melanoma progression.
Article
Biochemistry & Molecular Biology
Liang Pan, Shiyu Su, Yuanyuan Li, Di Liu, Lingyu Shen, Haiying Wang, Jiayu Wen, Hui Hu, Ruwen Zheng
Summary: The effects of acupuncture and finasteride on the expression of oestrogen receptors (ERs) alpha and beta in testosterone-induced benign prostatic hyperplasia (BPH) in rats were investigated. The results showed that both acupuncture and finasteride significantly improved the distribution of ERs and could improve BPH. Additionally, ER beta mRNA expression in the finasteride group was significantly different compared to the control and acupuncture groups, suggesting a potential mechanism of action for the treatment of BPH.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biology
Onruedee Khantisitthiporn, Byron Shue, Nicholas S. Eyre, Colt W. Nash, Lynne Turnbull, Cynthia B. Whitchurch, Kylie H. Van der Hoek, Karla J. Helbig, Michael R. Beard
Summary: The study found that viperin interacts with ISG Pex19, and is associated with peroxisomes and lipid droplets. The enhancement of the RLR signaling pathway by viperin is lost when Pex19 expression is reduced. Viperin requires the combined action of mitochondria and peroxisome MAVS to optimally induce IFN-beta.
LIFE SCIENCE ALLIANCE
(2021)
Review
Oncology
Diogo Martins-Branco, Guilherme Nader-Marta, Chiara Molinelli, Lieveke Ameye, Marianne Paesmans, Michail Ignatiadis, Philippe Aftimos, Roberto Salgado, Evandro de Azambuja
Summary: High Ki-67 index is associated with worse survival outcomes in women with ER-positive/HER2-negative early breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Chemistry, Organic
Yajie Yang, Lu Cheng, Mengdan Wang, Liqiang Yin, Ye Feng, Chengyu Wang, Yanzhong Li
Summary: A novel 1,2-difunctionalization of alkynones has been developed via an umpolung strategy for the synthesis of tetrasubstituted olefins. The approach features excellent yields, mild reaction conditions, a broad substrate scope, and operational simplicity.
Article
Cardiac & Cardiovascular Systems
Fernando S. Santiago, Yue Li, Ling Zhong, Mark J. Raftery, Laurence Lins, Levon M. Khachigian
Summary: The study identifies a truncated form of YY1 (YY1B) that can interact with BASP1 and inhibit smooth muscle cell proliferation, migration, and intimal hyperplasia after balloon injury of rat carotid arteries as effectively as full length YY1. This demonstrates the therapeutic potential of YY1B in vascular proliferative disease.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, General & Internal
Anna Kasielska-Trojan, Marian Danilewicz, Jerzy Struzyna, Magdalena Bugaj, Boguslaw Antoszewski
Summary: This study examined the receptor status of breast tissue in adult women with juvenile or idiopathic gigantomastia and found no correlation between excessive breast growth and the expression of ERα and PR. Analyzing the abnormal sensitivity of these receptors to hormones may be crucial in understanding the increased risk of breast cancer in women with gigantomastia.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Oncology
Yuanqin Zhang, Xiangwei Fang, Jiuhui Wang, Daotai Nie
Summary: TMEM97/sigma 2 receptor is highly expressed in ER-positive breast tumors and correlated with ERs and PRs. High expression of TMEM97 is associated with reduced overall survival of patients and increased resistance to tamoxifen treatment in breast cancer cells, as well as enhanced cell growth and ERα activity.
Article
Oncology
Linda R. Duska, Virginia L. Filiaci, Joan L. Walker, Laura L. Holman, Emily K. Hill, Richard G. Moore, Kari L. Ring, Michael L. Pearl, Carolyn Y. Muller, Christina L. Kushnir, Heather A. Lankes, Megan Samuelson, Kelley S. Carrick, Anand Rajan, William H. Rodgers, Elise C. Kohn, Richard Piekarz, Kimberly K. Leslie
Summary: This study evaluated the short-term effects of MPA alone versus MPA plus entinostat on regulating progesterone receptor in women with newly diagnosed endometrioid endometrial adenocarcinoma. Although no immediate impact on PR was observed with entinostat in this short-term study, combination therapy showed better results in reducing Ki-67 levels. Lessons learned from this trial can help guide future treatment studies.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Svenja Michalek, Thomas Goj, Anna Pia Plazzo, Blerim Marovca, Beat Bornhauser, Thomas Brunner
Summary: Nuclear receptors are transcription factors that play important roles in physiological and pathological processes. Glucocorticoids are essential for treating T-cell acute lymphoblastic leukemia (T-ALL), but resistance to glucocorticoid treatment is associated with poor prognosis and high risk of relapse. The study reveals that the interaction between glucocorticoid receptor (GR) and Liver Receptor Homolog-1 (LRH-1) critically regulates glucocorticoid sensitivity in T-ALL, providing new perspectives for developing therapeutic approaches to overcome glucocorticoid resistance.
Article
Oncology
Xue Pan, Xun Xu, Lixuan Wang, Siyuan Zhang, Yingyao Chen, Rongchun Yang, Xijuan Chen, Bin Cheng, Juan Xia, Xianyue Ren
Summary: This study found that upregulation of BASP1 is associated with poor survival in patients with head and neck squamous cell carcinoma (HNSCC). BASP1(high) patients exhibit better response rates to anti-PD-1 immunotherapy and higher expressions of immune checkpoint inhibitors. Furthermore, BASP1 is correlated with immune-related pathways and immunogenic ferroptosis signature. The results suggest that BASP1 suppresses immunogenic ferroptosis to induce an immunosuppressive tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stefanie Kowarschik, Julian Schoellkopf, Thomas Mueller, Songhai Tian, Julian Knerr, Hans Bakker, Stephan Rein, Min Dong, Stefan Weber, Robert Grosse, Gudula Schmidt
Summary: CNFY, a bacterial toxin produced by Yersinia pseudotuberculosis, activates Rho GTPases by binding with heparan sulfate proteoglycans and plays a major role in intoxication within the endosome rather than interacting at the cell surface.
Article
Multidisciplinary Sciences
Debarghya Dutta Banik, Laura E. Martin, Marc Freichel, Ann-Marie Torregrossa, Kathryn F. Medler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Vladimir Perovic, Neven Sumonja, Lindsey A. Marsh, Sandro Radovanovic, Milan Vukicevic, Stefan G. E. Roberts, Nevena Veljkovic
SCIENTIFIC REPORTS
(2018)
Article
Physiology
Tapan K. Nayak, Ridhima Vij, Iva Bruhova, Jayasha Shandilya, Anthony Auerbach
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Zachary C. Ahart, Laura E. Martin, Bailey R. Kemp, Debarghya Dutta Banik, Stefan G. E. Roberts, Ann-Marie Torregrossa, Kathryn F. Medler
Article
Genetics & Heredity
Debarghya Dutta Banik, Eric D. Benfey, Laura E. Martin, Kristen E. Kay, Gregory C. Loney, Amy R. Nelson, Zachary C. Ahart, Barrett T. Kemp, Bailey R. Kemp, Ann-Marie Torregrossa, Kathryn F. Medler
Article
Biochemistry & Molecular Biology
Tareg Belali, Chigeru Wodi, Bethany Clark, Man-Kim Cheung, Tim J. Craig, Gabrielle Wheway, Nicole Wagner, Kay-Dietrich Wagner, Stefan Roberts, Sean Porazinski, Michael Ladomery
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Article
Multidisciplinary Sciences
Amy E. Loats, Samantha Carrera, Anna F. Fleming, Abigail R. E. Roberts, Alice Sherrard, Eneda Toska, Alexander J. Moorhouse, Kathryn F. Medler, Stefan G. E. Roberts
Summary: The study reveals that the lipidated protein BASP1 recruits cholesterol to the promoter region of target genes in the cell nucleus through a conserved interaction motif, and that BASP1's interaction with cholesterol is required for chromatin remodeling and the direction of transcription programs controlling cell differentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Hematology
Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J. Mancini, Allison Blair, Kate J. Heesom, Alex Tonks, Richard L. Darley, Stefan G. Roberts, Rhys G. Morgan
Article
Multidisciplinary Sciences
Alexander J. Moorhouse, Amy E. Loats, Kathryn F. Medler, Stefan G. E. Roberts
Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Removal of active histone modifications H3K9ac and H3K4me3 by BASP1 requires N-terminal myristoylation, while placement of the repressive histone modification H3K27me3 does not require lipidation. BASP1 regulates activity of multiple transcription factors and induces extensive changes in chromatin accessibility, with about 50% of BASP1 target genes showing lipidation-dependent chromatin compaction and transcriptional repression.
Article
Oncology
Anuj Anuj, Nina Reuven, Stefan G. E. Roberts, Ari Elson
Summary: The cytokine RANKL is involved in the differentiation of monocytes/macrophages into bone-resorbing osteoclasts, and it down-regulates the expression of BASP1 which is a negative regulator of osteoclastogenesis. Knocking down or eliminating BASP1 enhances RANKL-induced osteoclastogenesis, promoting cell-cell fusion and increasing mineral degrading abilities of osteoclasts.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Physiology
Debarghya Dutta Banik, Kathryn F. Medler
Summary: The taste system uses distinct signaling pathways to detect chemicals in potential food items, with bitter, sweet and umami stimuli activating GPCR pathways while salt and sour are detected by ionotropic receptors. Recent studies suggest that the signaling processes in taste cells are more complex than previously appreciated.
CURRENT OPINION IN PHYSIOLOGY
(2021)
Article
Biology
Yankun Gao, Debarghya Dutta Banik, Mutia M. Muna, Stefan G. E. Roberts, Kathryn F. Medler
LIFE SCIENCE ALLIANCE
(2019)
Meeting Abstract
Behavioral Sciences
Kathryn F. Medler, Yankun Gao, Jayasha Shandilya, Stefan G. E. Roberts
