Article
Genetics & Heredity
Estefania Tarazon, Blanca de Unamuno Bustos, Rosa Murria Estal, Gema Perez Simo, Antonio Sahuquillo Torralba, Javier Simarro, Sarai Palanca Suela, Rafael Botella Estrada
Summary: Recent evidence suggests that miR-138-5p plays a central role in regulating hTERT expression in melanoma cells. Overexpression of miR-138-5p leads to decreased hTERT protein expression and telomerase activity, resulting in suppressed cell growth and migration abilities. Targeting miR-138-5p could be a potential strategy for advanced melanoma treatment.
Article
Medicine, Research & Experimental
Yi-Xia Lou, Jing Gu, Lei Zhu, Sheng-Qi Sun, Xiang-Lin Hao, Jian-Ping Chen, Fei Han, Dan-Dan Wang, Xiao Jiang, Jin-Yi Liu
Summary: This study demonstrates that TC2N promotes proliferation and metastasis in hepatocellular carcinoma (HCC) by activating the Wnt/I3-catenin signaling pathway. Therefore, TC2N might serve as a potential molecular target for the treatment of HCC.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockiam
Summary: Hepatocellular carcinoma (HCC) is the third leading malignancy worldwide, causing high mortality in adults and children. This study explored the expression and function of the miR-221/AEG-1 axis in HCC. The silencing of the miR-221/AEG-1 axis induced apoptosis and G2/M phase arrest, inhibited cellular proliferation and angiogenesis in HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yunjiang Zhou, Yaxin Chen, Yongwei Shi, Leyin Wu, Yingying Tan, Tao Li, Yigang Chen, Jiazeng Xia, Rong Hu
Summary: In this study, it was discovered that FAM117B promotes the growth of gastric cancer cells and reduces their sensitivity to chemotherapeutic drugs. Mechanistically, FAM117B competes with NRF2 for KEAP1 binding, reducing the degradation of NRF2 and activating the KEAP1/NRF2 signaling pathway, thus promoting the growth and chemoresistance of gastric cancer cells. The high expression of FAM117B and NRF2 in tumor tissues of gastric cancer patients is an independent factor for poor prognosis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Sunita Sinha, Satyendra Kumar Singh, Nitish Jangde, Rashmi Ray, Vivek Rai
Summary: Melanoma, originating from melanin-producing cells, carries a high risk due to its ability to rapidly spread and invade new organs. The role of p32 in melanoma progression and metastasis is still not fully understood, but knocking down p32 has been shown to reduce cell proliferation, migration, and invasion, and modulate the tumor microenvironment. p32 may serve as a potential target for novel therapeutic approaches in regulating melanoma progression and metastasis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xianling Guo, Xiaolan Yin, Yu Xu, Liang Li, Min Yuan, Huaxin Zhao, Yuxiong Jiang, Xiujuan Shi, Hongda Bi, Yeqiang Liu, Yong Chen, Qing Xu
Summary: This study reveals the involvement of TMED3 in malignant melanoma (MM) development, and suggests a potential therapeutic target for MM patients with high TMED3 expression.
CELL AND BIOSCIENCE
(2023)
Article
Cell Biology
Yuhan Zhang, Yan Chen, Lei Shi, Jie Li, Wenjuan Wan, Bowen Li, Doudou Liu, Xiaoshuang Li, Yuting Chen, Meng Xiang, Hao Chen, Bin Zeng, H. Rosie Xing, Jianyu Wang
Summary: The study demonstrates that extracellular vesicles (EVs) mediate the intercellular communication between melanoma stem cells (MSCs) and melanoma parental cells (MPCs), promoting metastasis through the miR-592/PTPN7/MAPK axis.
CELL DEATH DISCOVERY
(2022)
Article
Multidisciplinary Sciences
Youqian Wu, Chao Zhang, Xiaolan Liu, Zhengfu He, Bing Shan, Qingxin Zeng, Qingwei Zhao, Huaying Zhu, Hongwei Liao, Xufeng Cen, Xiaoyan Xu, Mengmeng Zhang, Tingjun Hou, Zhe Wang, Huanhuan Yan, Shuying Yang, Yaqin Sun, Yanying Chen, Ronghai Wu, Tingxue Xie, Wei Chen, Ayaz Najafov, Songmin Ying, Hongguang Xia
Summary: The study identifies compounds inducing PD-L1 degradation, with EGFR inhibitors promoting PD-L1 degradation through GSK3 alpha-mediated phosphorylation. ARIH1 is identified as the E3 ubiquitin ligase targeting PD-L1 for degradation and plays a critical role in anti-tumor immunity. This research suggests that GSK3 alpha and ARIH1 may be potential drug targets to enhance anti-tumor immunity and immunotherapies.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Yunlong Guo, Wenli Shi, Ruihua Fang
Summary: This study demonstrates that miR-18a-5p regulates proliferation, apoptosis, and autophagy in melanoma cells by targeting the EPHA7 gene. Inhibition of miR-18a-5p suppresses cell proliferation and induces apoptosis and autophagy, while overexpression of EPHA7 reverses these effects. This research provides insight into the role of miRNAs in the pathogenesis of melanoma.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Bo Lv, Xianzhuo Liu, Xinfeng Zhu, Min Huang
Summary: This study found that miR-382-5p is upregulated in hepatocellular carcinoma and can activate the PI3K/Akt signaling pathway by targeting PTEN, promoting HCC cell invasion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Allergy
Xiangzhi Wang, Chengyun Xu, Yuqing Cai, Xinyi Zou, Yunqi Chao, Ziyi Yan, Chaochun Zou, Ximei Wu, Lanfang Tang
Summary: This study revealed the high expression of circZNF652 in bronchoalveolar lavage fluid of allergic asthma patients and its role in promoting pathological goblet cell metaplasia through activation of the miR-452-5p/JAK2/STAT6 signaling pathway. These findings provide new strategies for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Plant Sciences
Tingting Lou, Qingxia Huang, Hang Su, Daqing Zhao, Xiangyan Li
Summary: Ginseng, a traditional Chinese herbal medicine, contains active components called ginsenosides which have various pharmacological effects. By targeting the SIRT1 signaling pathway, ginsenosides can be used for the prevention and treatment of multiple diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Huangheng Tao, Yixiang Liao, Youji Yan, Zhiwen He, Jiajie Zhou, Xinghuan Wang, Jianping Peng, Shangze Li, Tao Liu
Summary: This study revealed that high expression of BRCC3 in bladder cancer promotes tumorigenesis by targeting the TRAF2 protein, while genetic ablation of BRCC3 significantly blocks proliferation and migration of bladder cancer cells. RNA-Seq analysis shows down-regulation of NF-kappa B signaling in BRCC3-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rana S. Moubarak, Ana De Pablos-Aragoneses, Vanessa Ortiz-Barahona, Yixiao Gong, Michael Gowen, Igor Dolgalev, Sorin A. A. Shadaloey, Diana Argibay, Alcida Karz, Richard Von Itter, Eleazar Carmelo Vega-Saenz De Miera, Elena Sokolova, Farbod Darvishian, Aristotelis Tsirigos, Iman Osman, Eva Hernando
Summary: In this study, the researchers identified PHF8 as a previously unidentified prometastatic gene in melanoma. They found that PHF8 promotes cell invasion and is involved in the TGF beta signaling pathway, providing new insights into the epigenetic regulation of metastasis in cancer.
Article
Biochemistry & Molecular Biology
Tuoyang Li, Junyi Zhou, Yingming Jiang, Yandong Zhao, Jintuan Huang, Weiyao Li, Zhenze Huang, Zijian Chen, Xiaocheng Tang, Hao Chen, Zuli Yang
Summary: This study investigated the role of ADAMTS16 in gastric cancer and found that it promotes cell migration, invasion, and proliferation by targeting IFI27 through the NF-kappa B pathway. ADAMTS16 may serve as a potential biomarker for the progression and survival of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Fucheng Zhu, Guosi Li, Peipei Wei, Cheng Song, Qilin Xu, Menghua Ma, Jingbo Ma, Ping Song, Sen Zhang
Summary: The rational design of enzymes with enhanced thermostability is efficient. This study successfully improved the thermostability and synthetic activity of a metalloprotease through a rational strategy, resulting in mutants with increased stability and enhanced Z-aspartame synthesis activity. Molecular dynamics simulation revealed that increased hydrogen bond interactions and a regional hydration shell were key factors in enhancing thermostability. This research provides valuable insights for enzyme engineering and has significant implications in industrial applications.
ENZYME AND MICROBIAL TECHNOLOGY
(2023)
Article
Genetics & Heredity
Haoyu Pan, Yu Chen, Jingyi Zhao, Jie Huang, Nana Shu, Hui Deng, Cheng Song
Summary: With high-throughput sequencing technology, a total of 74 WRKY genes were identified from the genome of Dendrobium officinale. Detailed analysis of gene structure, conserved motifs, and phylogenetic relationships revealed that these genes can be classified into three main groups and five subgroups. Chromosomal localization analysis suggested a possible genome duplication event. Expression analysis suggested the involvement of certain WRKY genes in the JA signaling pathway.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Aijuan Tian, Huiyun Lv, Wei Liu, Jinbo Zhao, Shanshan Zhao, Kainan Wang, Chen Song
Summary: Approximately 75% of patients with advanced breast cancer develop bone metastasis, which significantly affects both the quality of life and the survival rate of patients. Accurate determination of the status of bone metastases is important for developing treatment strategies and the prognosis of the disease. This case report highlights the significance of distinguishing osteoblastic bone repair from real bone lesion progression in the clinical setting and provides new insights into strategies for the treatment of bone metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Applied
Zhiyu Yan, Yilan Yang, Qianqian Li, Yingwen Yan, Zemin Tian, Chen Song, Zuohua Huang
Summary: The effects of NH3 and/or H2 addition on soot formation and gas emission in a laminar ethylene diffusion flame were studied. NH3 addition can suppress PAH and soot formation by both dilutive and chemical effects, while H2 addition chemically promotes soot formation. The soot formation of NH3-H2 blends is between flames doped with pure NH3 and H2.
FUEL PROCESSING TECHNOLOGY
(2023)
Article
Engineering, Chemical
Ted Sperry, Yu Feng, Jianan Zhao, Chen Song, Zhiqiang Shi
Summary: Predicting the transport and deposition of e-cigarette aerosols in human respiratory systems is crucial for understanding the absorption of nicotine in the lung. This study used a computational fluid-particle dynamics (CFPD) method to model the aerosol transport dynamics and found that acidity levels in e-liquid can affect nicotine evaporation and delivery to the airways. The study also investigated the impact of e-liquid composition on droplet and vapor phase transport and absorption.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Chemistry, Physical
Zesheng Lin, Meiping Zhu, Chen Song, Tianbao Liu, Chaoyi Yin, Tingting Zeng, Jianda Shao
Summary: HfO2 monolayer coatings were prepared by plasma-enhanced atomic layer deposition (PEALD), and the effects of thermal annealing atmosphere and temperature on the properties of the coatings were investigated. The results showed that annealing in an oxygen atmosphere led to the decomposition of impurity compounds and the elimination of oxygen deficiency, resulting in lower absorption and higher laser-induced damage threshold (LIDT). The highest LIDT of 6.3 J/cm2 was obtained at an annealing temperature of 700°C, which was approximately three times higher than the as-deposited coating. This experimental result could be valuable for improving the LIDT of oxide coatings grown by PEALD or other similar methods.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Oncology
Na He, Bao-Zhu Guan, Jie Wang, Han-Kui Liu, Yong Mao, Zhi-Gang Liu, Fei Yin, Jing Peng, Bo Xiao, Bei-sha Tang, Dong Zhou, Guang Huang, Qi-Lin Dai, Ying Zeng, Hong Han, Qiong-Xiang Zhai, Bin Li, Bin Tang, Wen-Bin Li, Wang Song, Liu Liu, Yi-Wu Shi, Bing-Mei Li, Tao Su, Peng Zhou, Xiao-Rong Liu, Li-Wu Guo, Yong-Hong Yi, Wei-Ping Liao
Summary: This study revealed that HCFC1 variants are associated with common partial epilepsy and affect protein maturation by disrupting cleavage process, leading to impaired cell proliferation. However, these variants do not affect the expression of the MMACHC gene related to cobalamin metabolism. The degree of functional impairment is correlated with the severity of clinical phenotypes.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Food Science & Technology
Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo, Jinhong Hu, Lina Zhu, Xiaole Cui, Bing Chen, Lingling Li, Congli Cai, Haobo Cui, Tianli Yue
Summary: This study found that obesity induced by a high-fat diet leads to osteoporosis, but it is unclear whether the high-fat diet itself promotes osteoclastogenesis and bone loss. The results showed that non-obese mice are protected from bone loss induced by a high-fat diet through gut microbiome regulation.
NPJ SCIENCE OF FOOD
(2023)
Review
Genetics & Heredity
Muhammad Aamir Manzoor, Irfan Ali Sabir, Iftikhar Hussain Shah, Muhammad Waheed Riaz, Shamsur Rehman, Chen Song, Li Gouhui, M. Sanaullah Malik, Ghulam Abbas Ashraf, Muhammad Sajjad Haider, Yunpeng Cao, Muhammad Abdullah
Summary: Significant progress has been made in understanding the biosynthesis and regulation of flavonoids through genetic approaches, but there is still a gap in knowledge about their transport mechanisms. Currently, four transport models have been proposed, and research has been conducted on the proteins and genes associated with these models. Challenges still exist, but gaining a deeper understanding of these transport mechanisms holds great potential for various fields. This review aims to provide an overview of recent advancements in flavonoid transport mechanisms.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Agricultural Engineering
Yingyu Zhang, Wenwu Zhang, Muhammad Aamir Manzoor, Irfan Ali Sabir, Pengfei Zhang, Yunpeng Cao, Cheng Song
Summary: This study identified 64 WRKY genes in the genome of Dendrobium huoshanense and revealed their involvement in responding to both biotic and abiotic stresses. The subcellular localization analysis showed that most of the WRKY genes were located in the nucleus. The evolutionary analysis provided insights into the origin and duplication events of the WRKY genes in Dendrobium species, and identified DhWRKY42 as a key regulator involved in the regulation of jasmonic-acid-responsive genes.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Chen Song, Gregory C. Rutledge
Summary: Membrane technology is effective for treating emulsified oil-water mixtures, but fouling of the membrane reduces its capacity. Liquid-infused membranes (LIMs) show potential for resolving fouling issues, but their low permeate flux is a limitation. By using confocal laser scanning microscopy (CLSM) to analyze 3D images, we observe the coalescence of oil droplets and formation of oil channels in LIMs, which are influenced by factors such as oil concentration, infused liquid viscosity, and operating pressure. This study provides insights into the selective permeation of dispersed liquid phases through LIMs.
Article
Genetics & Heredity
Cheng Song, Yingyu Zhang, Yunpeng Zhang, Shanyong Yi, Haoyu Pan, Ranran Liao, Yuanyuan Wang, Bangxing Han
Summary: This study identified bolting-related genes in Peucedanum praeruptorum through transcriptome and genome analysis, and found that these genes are involved in transcription regulation, defense response, and carbohydrate metabolism. Genes related to lignin polymerization and phosphatidylinositol signaling system were also identified. These findings provide new insights for further research on the growth and medicinal properties of Peucedanum praeruptorum.
Article
Energy & Fuels
Boyuan Zhu, Jianghui Meng, Renfang Pan, Chen Song, Zhengping Zhu, Jineng Jin, Chaomo Zhang, Lihang Liu, Lingling Xu, Xueqing Zhou
Summary: In this study, multiple methods such as scanning electron microscopy, mercury intrusion porosimetry, low temperature gas adsorption, and logging data were used to quantitatively characterize the organic matter-hosted pores in the deep shale reservoirs of the Longmaxi Formation. The study focused on the impact of heterogeneity and deposition on the organic matter pore space, and obtained key findings.
GEOENERGY SCIENCE AND ENGINEERING
(2023)
Article
Plant Sciences
Guohui Li, Cheng Song, Muhammad Aamir Manzoor, Daoyuan Li, Yunpeng Cao, Yongping Cai
Summary: This study identified three PAL genes in the pear genome and revealed their significant impact on stone cell and lignin contents in pear fruits. Additionally, a transcription factor PbWLIM1 that regulates the transcription level of PbPAL2 was also discovered.
Article
Horticulture
Cheng Song, Muhammad Aamir Manzoor, Di Mao, Xiang Ren, Wenwu Zhang, Yingyu Zhang
Summary: This study found that the application of melatonin significantly enhanced various aspects of tomato plant growth and reduced the damage caused by cadmium stress. By increasing the activity of antioxidant enzymes and decreasing the levels of oxidative stress markers, melatonin improved the resistance of tomato plants to cadmium stress.
SCIENTIA HORTICULTURAE
(2024)
