Review
Cell Biology
Juan Segura-Aguilar, Bengt Mannervik, Jose Inzunza, Mukesh Varshney, Ivan Nalvarte, Patricia Munoz
Summary: Astrocytes play a vital role in protecting neurons by providing energy, defending against excitotoxicity, metabolizing fatty acids, and converting glutamate. A recent discovery suggests that astrocytes also protect dopamine neurons from neurotoxicity through the secretion of certain enzymes.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Yuria Hori, Reiho Tsutsumi, Kento Nasu, Alex Boateng, Yasuhiko Ashikari, Masaharu Sugiura, Makoto Nakajima, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, Takahiro Seki
Summary: The study identified ar-turmerone analogs that directly and potently protected dopaminergic neurons, even independently of microglial activation inhibition, possibly involving nuclear factor erythroid 2-related factor 2.
Article
Biochemical Research Methods
Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T. Williams, Malcolm G. Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J. Weber, Lei Wang, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Yulin Zhao, Marina E. Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong Li
Summary: Researchers have developed a series of fluorescent dopamine sensors with high sensitivity and selectivity, which can detect the spatiotemporal dynamics of dopamine release and measure neurochemical signaling in multiple brain regions. These sensors provide important tools for studying dopamine activity.
Article
Cell Biology
Zixuan Lin, Chen Chen, Dongqin Yang, Jianqing Ding, Guanghui Wang, Haigang Ren
Summary: DJ-1 plays a crucial role in neuroinflammation by facilitating the interaction between IκBα and p65 in microglia, resulting in the repression of microglial activation and the protection of DA neurons from inflammation-induced injury in Parkinson's disease.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Xingren Li, Xiuyin Wu, Xingyan Luo, Bingchao Yan, Chunfen Mo, Huijie Guo, Shuxia Yang, Yantang Wang, Yi Lai, Pematenzin Puno, Limei Li
Summary: The study found that Sis-25 exhibited significant immunosuppressive activity by targeting GSK3 beta both in vitro and in vivo, inhibiting multiple signaling pathways and cytokine expression, effectively suppressing immune responses and dermatitis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shou-Lun Lee, Jing-Ya Hsu, Ting-Chun Chen, Chun-Chih Huang, Tzong-Yuan Wu, Ting-Yu Chin
Summary: This study investigates the anti-neuroinflammatory and neuroprotective effects of Erinacine A (EA) in the edible mushroom Hericium erinaceus. The results show that EA pretreatment can inhibit glial cell activation and reduce the expression of proinflammatory mediators, leading to improved motor function and decreased neuroinflammation in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Guangshun Sun, Hanyuan Liu, Jie Zhao, Jinyu Zhang, Tian Huang, Guoqiang Sun, Siqi Zhao, Zihao Zhang, Hengsong Cao, Dawei Rong, Xiangyi Kong, Qinghua Ji, Li Liu, Xuehao Wang, Weiwei Tang, Yongxiang Xia
Summary: This study reveals that macrophage GSK3 beta deficiency can inhibit the development of HCC by inhibiting the M2 phenotype and enhance the sensitivity of anti-PD1 immunotherapy for HCC by decreasing PD-L1 ubiquitination. The expression of CD14(+)GSK3 beta(+) in PBMC can noninvasively predict anti-PD1 sensitivity in HCC patients, providing novel strategies to predict anti-PD1 sensitivity, increase anti-PD1 therapeutic effect, and bring new hope for HCC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Mariola Gimla, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hac, Magdalena Narajczyk, Irena Bylinska, Tristan A. Reekie, Anna Herman-Antosiewicz
Summary: UA derivative 5 shows superior activity in inhibiting the growth and proliferation of pancreatic cancer cells. It induces ER stress and calcium ion release, leading to cell vacuolization. In a xenograft model, it effectively suppresses tumor growth without causing toxicity to the kidneys or liver.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang
Summary: This study demonstrated that Dl-3-n-butylphthalide (NBP) protected dopaminergic neurons in Parkinson's disease by inhibiting ferroptosis. This protective effect may be achieved by regulating ferritin expression, promoting Nrf2 nuclear translocation, and inhibiting NCOA4-mediated ferritinophagy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Multidisciplinary Sciences
Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou-Litina, Mourad Chioua, Francisco Lopez-Munoz, Jose Marco-Contelles, Ricardo Martinez-Murillo, Maria Jesus Oset-Gasque
Summary: Cerebral ischemia is a growing global problem and the leading cause of disability. Researchers have focused on finding neuroprotective drugs that target the molecular processes involved in cerebral ischemia. Six new quinolylnitrones (QNs) have been discovered, which show promising neuroprotective and antioxidant properties against ischemia-reperfusion in neuronal cultures. Among these QNs, QN6 demonstrates the highest antioxidant power and neuroprotective effect, making it a potential candidate for cerebral ischemia therapy.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hye Ji Jang, Kwang Chul Chung
Summary: This study reveals a dynamic interplay between ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway (ALP) in neurotoxin-based cell death models of Parkinson's disease, indicating their involvement in regulating cell death pathways.
Article
Biochemistry & Molecular Biology
Alexandre Henriques, Laura Rouviere, Elodie Giorla, Clemence Farrugia, Bilal El Waly, Philippe Poindron, Noelle Callizot
Summary: Mitochondria, alpha-syn fibrils, and the endo-lysosomal system play important roles in the development of Parkinson's disease. The toxicity of alpha-syn is increased by cell-to-cell transmission and aggregation. This study used dopaminergic neuron cultures and aged mice as models and found that exogenous alpha-syn causes cytotoxicity by affecting mitochondrial function, oxidative stress, and lysosomal accumulation. Inhibiting the endocytosis of alpha-syn prevents neurodegeneration in dopaminergic neurons, while injection of alpha-syn in vivo leads to progressive neurodegeneration and motor deficits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yang Yao, Mingyue Lin, Zhujun Liu, Mengyang Liu, Shiheng Zhang, Yukun Zhang
Summary: New drugs or active leads with high efficiency and low toxicity are needed for lung cancer treatment. This study found that hesperidin, a compound derived from citrus plants, shows potential therapeutic effects against lung cancer by regulating the expression of pinX1 protein and influencing cancer cell behavior.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yuyang Sun, Pramod Sukumaran, Brij B. Singh
Summary: Regulation of Ca(2+) homeostasis through sigma 1 receptor contributes to the loss of dopaminergic cells by blocking TRPC1-mediated Ca(2+) entry. Downregulation of sigma 1 receptor expression significantly decreases neurotoxin-induced loss of dopaminergic cells. Silencing of TRPC1 can prevent increased neuroprotection and caspase activity upon downregulation of sigma 1 receptor.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Rui Wang, Haigang Ren, Elena Kaznacheyeva, Xiaojun Lu, Guanghui Wang
Summary: This article provides an overview of the role of glia and alpha-syn pathology in the pathogenesis of Parkinson's disease (PD), highlighting the relationships between glial responses and the spread of alpha-syn pathology.
NEUROSCIENCE BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Hong-yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Elena Kaznacheyeva, Xiao-jun Lu, Hai-gang Ren, Guang-hui Wang
Summary: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons and the accumulation of Lewy bodies in the substantia nigra. Microglia-mediated neuroinflammation plays a key role in PD pathogenesis. In this study, we found that pazopanib, a pan-VEGF receptor tyrosine kinase inhibitor, showed anti-inflammatory and neuroprotective effects in PD models.
ACTA PHARMACOLOGICA SINICA
(2023)
Editorial Material
Neurosciences
Hongyang Sun, Guanghui Wang
NEUROSCIENCE BULLETIN
(2023)
Editorial Material
Geriatrics & Gerontology
Rui Wang, Haigang Ren, Li-Fang Hu, Ning Song, Ling Long, Zili You, Guanghui Wang
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xuebing Ding, Yongkang Chen, Cancan Guo, Yu Fu, Chi Qin, Qingyong Zhu, Jiuqi Wang, Rui Zhang, Haiyan Tian, Renyi Feng, Han Liu, Dongxiao Liang, Guanghui Wang, Junfang Teng, Jinchen Li, Beisha Tang, Xuejing Wang
Summary: This research report identifies that mutations in the ARHGEF15 gene are a cause of cerebral small vessel disease (CSVD), and individuals with these mutations also exhibit osteoporosis and fractures.
ACTA NEUROPATHOLOGICA
(2023)
Article
Chemistry, Multidisciplinary
Le-le Liu, Yu Han, Zi-jia Zhang, Yi-qi Wang, Yu-wei Hu, Elena Kaznacheyeva, Jian-qing Ding, Dong-kai Guo, Guang-hui Wang, Bin Li, Hai-gang Ren
Summary: Parkinson's disease is a neurodegenerative motor disorder characterized by reduced dopamine levels. The loss of DJ-1 function leads to increased expression of MAO-B, which is associated with dopamine degradation, oxidative stress, and mitochondrial dysfunction. This study reveals the mechanistic link between DJ-1 and MAO-B expression and contributes to understanding the pathogenesis of Parkinson's disease.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Jiayuan Wu, Juanfen Mo, Wei Xiang, Xiaowen Shi, Li Guo, Yi Li, Yi Bao, Li Zheng
Summary: Polysaccharide of Tetrastigma hemsleyanum (THP) exhibits antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, with evidence suggesting its efficacy as an anti-tumor agent. However, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still unclear. This study investigated the activation of Raw264.7 cells by THP, and demonstrated its potential as a new immunomodulator in functional foods and pharmaceuticals.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yixin Wang, Liu Liu, Hui Chen, Yinxue Yang, Chenchen Mu, Haigang Ren, Yanli Liu, Liqiang Yu, Qi Fang, Guanghui Wang, Zongbing Hao
Summary: This study identified severe DNA damage caused by poly-PR and its interaction with the ALS-related FUS protein, suggesting a potential therapeutic role of FUS in alleviating poly-PR-induced cell toxicity.
HUMAN MOLECULAR GENETICS
(2023)
Article
Cell Biology
Xingyun Xu, Hang Zhou, Hainan Wu, Zhigang Miao, Bo Wan, Haigang Ren, Wei Ge, Guanghui Wang, Xingshun Xu
Summary: The lateral habenula (LHb) is known to affect social behaviors, but its role in regulating social interaction is unclear. This study demonstrates that the methylase Tet2 is highly expressed in the LHb and its deficiency leads to impaired social preference in mice. Replenishing Tet2 in the LHb can rescue this impairment, suggesting that Tet2 in the LHb may be a therapeutic target for social behavior deficits.
Article
Multidisciplinary Sciences
Jin Wu, Yingying Han, Hao Xu, Hongyang Sun, Rui Wang, Haigang Ren, Guanghui Wang
Summary: This study investigates the role of chaperone-mediated autophagy (CMA) in neuroinflammation and its impact on microglia activation and neuronal damage. The researchers found that CMA activation can inhibit microglial activation and inflammation through the p300-associated NF-kappa B signaling pathway. Additionally, they demonstrated that CMA dysfunction worsens microglial activation and inflammation. These findings provide insight into the mechanistic link between CMA and neuroinflammation.