Article
Immunology
Elisa McEachern, Allison M. Carroll, Miguel Fribourg, Thomas D. Schiano, Susan Hartzell, Sofia Bin, Paolo Cravedi, Josh Levitsky
Summary: This study found that treatment with EPO in stable AIH patients increased overall Treg levels, particularly those expressing the high function marker HLA-DR. These results support further research into the potential of using EPO or EPO analogues to improve outcomes in AIH patients by boosting Treg levels.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Immunology
Maria Serena Longhi, Giorgina Mieli-Vergani, Diego Vergani
Summary: Regulatory T-cells are crucial for maintaining immune balance and defects can lead to autoimmune attacks; Tregs acquiring effector cell features support the perpetuation of autoimmune damage. In autoimmune liver diseases, Treg impairment is permissive for disease initiation and progression.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Chen Huang, Yi Shen, Mengyi Shen, Xiaoli Fan, Ruoting Men, Tinghong Ye, Li Yang
Summary: This study revealed decreased peripheral Treg frequency and abnormal intrahepatic Treg infiltration in AIH. It is associated with glucose metabolism reprogramming, resulting in decreases and functional impairments in the Treg population, which promotes AIH development. Targeting glucose metabolism may provide novel insights for the treatment of AIH.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Zheng Huang, Shangshu Nie, Han Wang, Wei Yan, Dean Tian, Mei Liu
Summary: This systematic review and meta-analysis found that the proportions of regulatory T cells (Tregs) were decreased in autoimmune hepatitis (AIH) patients compared to healthy controls. The results were influenced by Treg definition, ethnicity, and disease activity. Further large-scale and rigorous studies are needed to confirm these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Chiao-Fang Teng, Tsai-Chung Li, Ting Wang, Da-Ching Liao, Yi-Hsuan Wen, Tzu-Hua Wu, John Wang, Han-Chieh Wu, Woei-Cherng Shyu, Ih-Jen Su, Long-Bin Jeng
Summary: Hepatocellular carcinoma (HCC) is closely associated with chronic hepatitis B virus (HBV) infection. The oncoprotein pre-S2 mutant plays important roles in HCC development and is linked to poor prognosis in HCC patients. In pre-S2 mutant-positive HCC patients, there is a higher infiltration of regulatory T cells (Tregs) but a lower infiltration of cytotoxic T lymphocytes (CTLs) in tumor tissues.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Davide Neri, Melanie Carevic-Neri, Juergen Brueck, Julia Holstein, Iris Schaefer, Farzan Solimani, Rupert Handgretinger, Dominik Hartl, Kamran Ghoreschi
Summary: This study identified an expanded population of PMN-MDSCs in pemphigus patients, with the ability to suppress T-cell proliferation and increased expression of characteristic effector molecules. The frequency of MDSCs was also found to correlate with an increased Th2/Th1 cell ratio in pemphigus patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Review
Immunology
Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Summary: Treg cell plasticity plays a significant role in autoimmunity and cancer, characterized by loss of Foxp3 expression. It has great therapeutic potential through destabilizing Treg cells to promote anti-tumor immunity or enhancing Treg cell stability to attenuate chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Shirin Hafezi, Hawra Ali Hussain Alsayed, Balachandar Selvakumar, Mariam Wed Abdelaziz Eladham, Bushra Mdkhana, Ola Salam Bayram, Mohamad-Hani Temsah, Rabih Halwani
Summary: The levels of regulatory T and B cells are altered in severe COVID-19, especially in the presence of autoantibodies to type I IFNs. Treatment with tocilizumab and/or high dose of Vitamin D can increase the levels of these regulatory cells and improve control of inflammation.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Fatemeh Bayati, Mahsa Mohammadi, Maryam Valadi, Saeid Jamshidi, Arron Munggela Foma, Ehsan Sharif-Paghaleh
Summary: Regulatory T cells (Tregs) are a subgroup of CD4(+) T cells that play a key role in immune tolerance regulation, preventing autoimmunity and aiding tumor evasion of immune recognition. Their therapeutic potential in transplantation, autoimmune diseases, and cancer therapy is being actively studied for improving treatment options.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ke Jin, Simon Parreau, Kenneth J. Warrington, Matthew J. Koster, Gerald J. Berry, Joerg J. Goronzy, Cornelia M. Weyand
Summary: Vasculitides, a group of diseases causing vascular damage, result in loss of immune privilege and uncontrolled inflammation. Deficiencies in immunosuppressive regulatory T cells (Treg) play a crucial role, with different vasculitides being affected by distinct mechanisms. Exploring the mechanisms behind insufficient immunosuppression and vascular inflammation holds promise for novel therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Amund Holte Berger, Eirik Bratland, Thea Sjogren, Marte Heimli, Torgeir Tyssedal, Oyvind Bruserud, Stefan Johansson, Eystein Sverre Husebye, Bergithe Eikeland Oftedal, Anette Susanne Boe Wolff
Summary: APS-1 is a monogenic disorder of organ-specific autoimmunity caused by mutations in the AIRE gene. Tregs in APS-1 patients may have reduced numbers and function, with some genes showing deviant expression. Functional studies are needed to determine the significance of these findings for the immunopathogenesis of APS-1 and Treg immunobiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind
Summary: This study found that dendritic cells (DC) in the blood of patients with graft-versus-host disease (GvHD) play a crucial role in activating and proliferating T cells. Conversely, transferred iNKT cells inhibit allogeneic reactions of T cells by inducing apoptosis in specific subsets of DC, promoting beneficial immune responses.
Article
Immunology
Tanvi Khera, Yanqin Du, Daniel Todt, Katja Deterding, Benedikt Strunz, Svenja Hardtke, Amare Aregay, Kerstin Port, Matthias Hardtke-Wolenski, Eike Steinmann, Niklas K. Bjorkstrom, Michael P. Manns, Julia Hengst, Markus Cornberg, Heiner Wedemeyer
Summary: Patients with acute hepatitis C infection showed significant alterations in soluble inflammatory mediators compared to chronic hepatitis patients and healthy controls. Early treatment with DAAs partially normalized these changes, but long-lasting imprints of HCV remained.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Oncology
Sandra Bufe, Artur Zimmermann, Sarina Ravens, Immo Prinz, Laura Elisa Buitrago-Molina, Robert Geffers, Norman Woller, Florian Kuehnel, Steven R. Talbot, Fatih Noyan, Michael Peter Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel, Ana C. Davalos-Misslitz
Summary: This study established a new orthotopic HCC model and found that a small dose of checkpoint inhibitors during the priming of transferred CD8+ tumor-specific T cells was sufficient to induce tumor remission. PD-1/CTLA-4 blockade did not improve the effector function of CD8+PD-1high TILs but had an ameliorative effect on CD8+PD-1int TILs.
Article
Immunology
Jakob Kremer, Pierre Henschel, Daniel Simon, Tobias Riet, Christine Falk, Matthias Hardtke-Wolenski, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Summary: The study demonstrated that enhancing the function and stability of CAR-Tregs through membrane-associated IL-2 expression is effective. The results showed that these cells are more stable under inflammatory conditions, survive better in the Treg niche, and are resistant to CNI therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Tom Pieper, Kristian Daniel Ralph Roth, Viktor Glaser, Tobias Riet, Laura Elisa Buitrago-Molina, Maike Hagedorn, Maren Lieber, Michael Hust, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Summary: Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in treating autoimmune diseases. However, obtaining sufficient antigen-specific Tregs from patients with autoimmune disorders remains challenging. In this study, researchers aimed to generate CARs against TSPAN7, a membrane protein highly expressed on the surface of pancreatic beta cells, using phage display technology. Although the resulting CARs were functional and specifically activated by the target structure, they could not recognize TSPAN7 on the surface of beta cells. This study demonstrates the power of CAR technology in generating antigen-specific T cells and provides new approaches for functional CAR generation.
Article
Immunology
Pierre Henschel, Sybille Landwehr-Kenzel, Niklas Engels, Andrea Schienke, Jakob Kremer, Tobias Riet, Nella Redel, Konstantinos Iordanidis, Valerie Saetzler, Katharina John, Miriam Heider, Matthias Hardtke-Wolenski, Heiner Wedemeyer, Elmar Jaeckel, Fatih Noyan
Summary: Researchers have developed an HLA-A2specific CAR vector that co-expresses FOXP3, which can increase the safety and efficacy of CAR-Treg products. Stable expression of FOXP3 in Tregs prevents conversion into pathogenic T effector cells under pro-inflammatory conditions.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Cell Biology
Valerie Saetzler, Tobias Riet, Andrea Schienke, Pierre Henschel, Kiara Freitag, Alexander Haake, Frank L. Heppner, Laura Elisa Buitrago-Molina, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Summary: In this study, a chimeric antigen receptor (CAR) targeting beta-amyloid was generated using an antibody-like single-chain variable fragment from a phage library. The obtained CAR-Tregs showed antigen-specific activation and suppressive capacity. This study highlights the potential of CAR technology in generating antigen-specific Tregs and provides novel approaches for developing functional CARs.
Meeting Abstract
Immunology
Katharina Zimmermann, Pierre Henschel, Daniel Simon, Matthias Hardtke-Wolenski, Tobias Riet, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Meeting Abstract
Immunology
P. Henschel, J. Kremer, M. Hardtke-Wolenski, H. Wedemeyer, F. Noyan, E. Jaeckel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Ue. Karsli, V. Saetzler, T. Riet, M. Hardtke-Wolenski, E. Jaeckel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
J. Kremer, P. Henschel, M. Hardtke-Wolenski, T. Riet, C. Falk, H. Wedemeyer, F. Noyan, E. Jaeckel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
T. Pieper, V. Glaser, T. Riet, M. Hagedorn, M. Lieber, M. Hust, H. Wedemeyer, F. Noyan, M. Hardtke-Wolenski, J. Elmar
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
V. Saetzler, T. Riet, A. Schienke, M. Hust, H. Wedemeyer, F. Noyan, M. Hardtke-Wolenski, E. Jaeckel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Janine Dywicki, Laura Elisa Buitrago-Molina, Fatih Noyan, Jerome Schlue, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski
Summary: This study found that splenectomy in late-stage autoimmune hepatitis can induce an increase in intrahepatic regulatory T cells, biochemical remission, and regeneration.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Janine Dywicki, Laura Elisa Buitrago-Molin, Fatih Noyan, Ana C. Davalos-Misslitz, Katharina L. Hupa-Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel
Summary: Studies have shown that feeding NASH-resistant BALB/c mice with a high-fat high-carbohydrate diet can activate intrahepatic T cells, while the absence of the adaptive immune response has a significant impact on NASH. The increase in intrahepatic Treg numbers in NASH patients did not improve NASH and unexpected had negative effects when Treg transfer or anti-CD3 therapy were attempted.
HEPATOLOGY COMMUNICATIONS
(2022)
