Making Heads or Tails of It: Cell–Cell Adhesion in Cellular and Supracellular Polarity in Collective Migration

Collective cell migration in development

(2016) Elena Scarpa et al.   JOURNAL OF CELL BIOLOGY

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

(2016) Cédric Plutoni et al.   JOURNAL OF CELL BIOLOGY

Integrins synergise to induce expression of the MRTF-A–SRF target gene ISG15 for promoting cancer cell invasion

(2016) Michaela-Rosemarie Hermann et al.   JOURNAL OF CELL SCIENCE

Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track

(2016) Jiao Li et al.   PLoS One

Cell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis

(2016) David Ellison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Cadherin Regulates Cell Migration Through a Rab5-Dependent Temporal Control of Macropinocytosis

(2016) Meng-Hsuan Wen et al.   TRAFFIC

Front–Rear Polarization by Mechanical Cues: From Single Cells to Tissues

(2016) Benoit Ladoux et al.   TRENDS IN CELL BIOLOGY

Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement

(2016) Yongliang Yang et al.   Scientific Reports

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology

(2015) Dörthe Jülich et al.   DEVELOPMENTAL CELL

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

(2015) Jill M. Westcott et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

(2015) Massiullah Shafaq-Zadah et al.   NATURE CELL BIOLOGY

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Control of cell–cell forces and collective cell dynamics by the intercellular adhesome

(2015) Elsa Bazellières et al.   NATURE CELL BIOLOGY

Physics of active jamming during collective cellular motion in a monolayer

(2015) Simon Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell migration: guidance principles and hierarchies

(2015) Anna Haeger et al.   TRENDS IN CELL BIOLOGY

Gap geometry dictates epithelial closure efficiency

(2015) Andrea Ravasio et al.   Nature Communications

Notch1–Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration

(2015) Reza Riahi et al.   Nature Communications

Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices

(2015) Nikolce Gjorevski et al.   Scientific Reports

Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K

(2015) Naoya Yamaguchi et al.   Scientific Reports

Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration

(2015) Yim Ling Cheng et al.   Cell Reports

NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells

(2015) Alessandro Fantin et al.   Cell Reports

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation

(2014) C. Revenu et al.   DEVELOPMENT

Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium

(2014) D. Dalle Nogare et al.   DEVELOPMENT

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

(2014) Jennifer L. Bays et al.   JOURNAL OF CELL BIOLOGY

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

(2014) M. Reffay et al.   NATURE CELL BIOLOGY

Adherens junction treadmilling during collective migration

(2014) Florent Peglion et al.   NATURE CELL BIOLOGY

3D in vitro cell culture models of tube formation

(2014) Mirjam M. Zegers   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tip cells: Master regulators of tubulogenesis?

(2014) Helen Weavers et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

I’m coming to GEF you: Regulation of RhoGEFs during cell migration

(2014) Silvia M Goicoechea et al.   Cell Adhesion & Migration

TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives

(2014) Takuya Kato et al.   Cell Reports

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal

(2014) Andrew J. Muinonen-Martin et al.   PLOS BIOLOGY

Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration

(2013) Sebastian Rausch et al.   Biointerphases

Guidance of collective cell migration by substrate geometry

(2013) Kevin Doxzen et al.   Integrative Biology

The Hippo pathway polarizes the actin cytoskeleton during collective migration ofDrosophilaborder cells

(2013) Eliana P. Lucas et al.   JOURNAL OF CELL BIOLOGY

Specification of leading and trailing cell features during collective migration in the Drosophila trachea

(2013) G. Lebreton et al.   JOURNAL OF CELL SCIENCE

Directional tissue migration through a self-generated chemokine gradient

(2013) Erika Donà et al.   NATURE

Rab11 regulates cell–cell communication during collective cell movements

(2013) Damien Ramel et al.   NATURE CELL BIOLOGY

Functions of cofilin in cell locomotion and invasion

(2013) Jose Javier Bravo-Cordero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

(2013) A. F. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways

(2013) Mingxing Ouyang et al.   Nature Communications

Formation of a PKC / -catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting

(2012) M. Oubaha et al.   BLOOD

Myosin-IXA Regulates Collective Epithelial Cell Migration by Targeting RhoGAP Activity to Cell-Cell Junctions

(2012) Tatiana Omelchenko et al.   CURRENT BIOLOGY

Cadherins in collective cell migration of mesenchymal cells

(2012) Eric Theveneau et al.   CURRENT OPINION IN CELL BIOLOGY

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation

(2012) Katja Röper   DEVELOPMENTAL CELL

Fellow travellers: emergent properties of collective cell migration

(2012) Pernille Rørth   EMBO REPORTS

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility

(2012) Mei Rosa Ng et al.   JOURNAL OF CELL BIOLOGY

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

(2012) Nicolas Reymond et al.   JOURNAL OF CELL BIOLOGY

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

(2012) A. J. Ewald et al.   JOURNAL OF CELL SCIENCE

N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migration

(2012) Emeline Camand et al.   JOURNAL OF CELL SCIENCE

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell–cell junctions by differentially regulating Tiam1 activity

(2012) Natalie A. Mack et al.   NATURE CELL BIOLOGY

A bigger picture: classical cadherins and the dynamic actin cytoskeleton

(2012) Aparna Ratheesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts

(2012) J. G. Dumortier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coherent angular motion in the establishment of multicellular architecture of glandular tissues

(2012) K. Tanner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

(2012) L. Trichet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Branching Morphogenesis: From Cells to Organs and Back

(2012) A. Ochoa-Espinosa et al.   Cold Spring Harbor Perspectives in Biology

Switchable adhesive substrates: Revealing geometry dependence in collective cell behavior

(2011) Claudio G. Rolli et al.   BIOMATERIALS

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

(2011) Soline Estrach et al.   CIRCULATION RESEARCH

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

(2011) Lin Huo et al.   EMBO JOURNAL

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

(2011) Denise Stenzel et al.   EMBO REPORTS

Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells

(2011) Miguel Vicente-Manzanares et al.   JOURNAL OF CELL BIOLOGY

Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation

(2011) Liwei Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Ups and Downs of Guided Vessel Sprouting: The Role of Polarity

(2011) Christina Y. Lee et al.   PHYSIOLOGY

Connexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics

(2011) Richard Francis et al.   PLoS One

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and β1-integrin-dependent mechanism

(2010) Michael P. Hunter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Velocity Fields in a Collectively Migrating Epithelium

(2010) L. Petitjean et al.   BIOPHYSICAL JOURNAL

p120-catenin Is Essential for N-cadherin-mediated Formation of Proper Junctional Structure, thereby Establishing Cell Polarity in Epithelial Cells

(2010) Chisa Ozaki et al.   CELL STRUCTURE AND FUNCTION

Movement Directionality in Collective Migration of Germ Layer Progenitors

(2010) Yohanna Arboleda-Estudillo et al.   CURRENT BIOLOGY

Cellular mechanisms regulating epithelial morphogenesis and cancer invasion

(2010) Ryan S Gray et al.   CURRENT OPINION IN CELL BIOLOGY

The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells

(2010) Dan Du et al.   DEVELOPMENTAL CELL

Determinants of leader cells in collective cell migration

(2010) Antoine A. Khalil et al.   Integrative Biology

N-cadherin Cell-Cell Adhesion Complexes Are Regulated by Fibronectin Matrix Assembly

(2010) Craig T. Lefort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 localization and cell polarity depend on membrane traffic

(2010) Naël Osmani et al.   JOURNAL OF CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

A Steering Model of Endothelial Sheet Migration Recapitulates Monolayer Integrity and Directed Collective Migration

(2010) P. Vitorino et al.   MOLECULAR AND CELLULAR BIOLOGY

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junctional trafficking and epithelial morphogenesis

(2009) Frederik Wirtz-Peitz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development

(2009) D. Y. Rhee et al.   DEVELOPMENT

Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis

(2009) Xuan Chi et al.   DEVELOPMENTAL CELL

Classical cadherins control nucleus and centrosome position and cell polarity

(2009) Isabelle Dupin et al.   JOURNAL OF CELL BIOLOGY

Cell polarity triggered by cell-cell adhesion via E-cadherin

(2009) R. A. Desai et al.   JOURNAL OF CELL SCIENCE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKC  Regulation of an  5 Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells

(2009) S. Tuomi et al.   Science Signaling

Molecular Bases of Cell-Cell Junctions Stability and Dynamics

(2009) M. Cavey et al.   Cold Spring Harbor Perspectives in Biology

Remodeling Epithelial Cell Organization: Transitions Between Front-Rear and Apical-Basal Polarity

(2009) W. J. Nelson   Cold Spring Harbor Perspectives in Biology

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

ACF7 Regulates Cytoskeletal-Focal Adhesion Dynamics and Migration and Has ATPase Activity

(2008) Xiaoyang Wu et al.   CELL

Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture

(2008) M. Affolter et al.   DEVELOPMENT

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Modular control of endothelial sheet migration

(2008) P. Vitorino et al.   GENES & DEVELOPMENT

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE