Membrane Currents, Gene Expression, and Circadian Clocks

Synchronous Drosophila circadian pacemakers display nonsynchronous Ca2+ rhythms in vivo

(2016) X. Liang et al.   SCIENCE

BK channel inactivation gates daytime excitability in the circadian clock

(2016) Joshua P. Whitt et al.   Nature Communications

Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

(2015) Joshua L. Wang et al.   ANNALS OF NEUROLOGY

The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus

(2015) Takashi Kudo et al.   ASN Neuro

A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability

(2015) Matthieu Flourakis et al.   CELL

Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons

(2015) John R. Clay   JOURNAL OF NEUROPHYSIOLOGY

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

(2015) Jeff R Jones et al.   NATURE NEUROSCIENCE

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

Aging and circadian rhythms

(2015) Jadwiga M Giebultowicz et al.   Current Opinion in Insect Science

Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila

(2014) Michael Kunst et al.   CURRENT BIOLOGY

A Specific Role for the REV-ERBα–Controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in Resetting the Circadian Clock in the Late Night

(2014) Isabelle Schmutz et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity

(2014) Kanwal Sakhi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dual PDF Signaling Pathways Reset Clocks Via TIMELESS and Acutely Excite Target Neurons to Control Circadian Behavior

(2014) Adam Seluzicki et al.   PLOS BIOLOGY

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Genetically Targeted Optical Electrophysiology in Intact Neural Circuits

(2013) Guan Cao et al.   CELL

E and M Circadian Pacemaker Neurons Use Different PDF Receptor Signalosome Components in Drosophila

(2013) Laura B. Duvall et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Daily variation in the electrophysiological activity of mouse medial habenula neurones

(2013) Kanwal Sakhi et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Gq-Ca2+ Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus

(2013) Marco Brancaccio et al.   NEURON

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations

(2012) Wenyu Luo et al.   AGING CELL

Mis-expression of the BK K+ channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior

(2012) Jenna R. Montgomery et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Electrical Activity Can Impose Time of Day on the Circadian Transcriptome of Pacemaker Neurons

(2012) Dogukan Mizrak et al.   CURRENT BIOLOGY

A Mechanism for Circadian Control of Pacemaker Neuron Excitability

(2012) Marc Ruben et al.   JOURNAL OF BIOLOGICAL RHYTHMS

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity

(2012) D. Granados-Fuentes et al.   JOURNAL OF NEUROSCIENCE

Evidence for Neuronal Desynchrony in the Aged Suprachiasmatic Nucleus Clock

(2012) S. Farajnia et al.   JOURNAL OF NEUROSCIENCE

Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability

(2012) J. R. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

(2012) T. A. Wang et al.   SCIENCE

Autoreceptor Control of Peptide/Neurotransmitter Corelease from PDF Neurons Determines Allocation of Circadian Activity in Drosophila

(2012) Charles Choi et al.   Cell Reports

The Circadian Neuropeptide PDF Signals Preferentially through a Specific Adenylate Cyclase Isoform AC3 in M Pacemakers of Drosophila

(2012) Laura B. Duvall et al.   PLOS BIOLOGY

Adult-Specific Electrical Silencing of Pacemaker Neurons Uncouples Molecular Clock from Circadian Outputs

(2011) Ana Depetris-Chauvin et al.   CURRENT BIOLOGY

Aging of Intrinsic Circadian Rhythms and Sleep in a Diurnal Nonhuman Primate, Macaca mulatta

(2011) I.V. Zhdanova et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Evidence for RGS4 Modulation of Melatonin and Thyrotrophin Signalling Pathways in the Pars Tuberalis

(2011) S. M. Dupré et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fast Delayed Rectifier Potassium Current: Critical for Input and Output of the Circadian System

(2011) T. Kudo et al.   JOURNAL OF NEUROSCIENCE

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Linking neural activity and molecular oscillations in the SCN

(2011) Christopher S. Colwell   NATURE REVIEWS NEUROSCIENCE

Attenuated Food Anticipatory Activity and Abnormal Circadian Locomotor Rhythms in Rgs16 Knockdown Mice

(2011) Naoto Hayasaka et al.   PLoS One

CRYPTOCHROME Is a Blue-Light Sensor That Regulates Neuronal Firing Rate

(2011) K. J. Fogle et al.   SCIENCE

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

(2011) Masao Doi et al.   Nature Communications

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Circadian clock resetting in the mouse changes with age

(2009) Stephany M. Biello   AGE

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

(2009) Louisa M-C Wang et al.   ASN Neuro

Cellular Dissection of Circadian Peptide Signals with Genetically Encoded Membrane-Tethered Ligands

(2009) Charles Choi et al.   CURRENT BIOLOGY

Specializations of gastrin releasing peptide cells of the mouse suprachiasmatic nucleus

(2009) Elise Drouyer et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Circadian Regulation of A-Type Potassium Currents in the Suprachiasmatic Nucleus

(2009) Jason N. Itri et al.   JOURNAL OF NEUROPHYSIOLOGY

Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits

(2009) JOUKJE M. OOSTERMAN et al.   JOURNAL OF SLEEP RESEARCH

Daily Electrical Silencing in the Mammalian Circadian Clock

(2009) M. D. C. Belle et al.   SCIENCE

Tetraethylammonium (TEA) increases the inactivation time constant of the transient K+ current in suprachiasmatic nucleus neurons

(2008) Ludovic Alvado et al.   BRAIN RESEARCH

Electrical Silencing of PDF Neurons Advances the Phase of non-PDF Clock Neurons in Drosophila

(2008) Ying Wu et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian Control of Membrane Excitability in Drosophila melanogaster Lateral Ventral Clock Neurons

(2008) G. Cao et al.   JOURNAL OF NEUROSCIENCE

BK Channels Regulate Spontaneous Action Potential Rhythmicity in the Suprachiasmatic Nucleus

(2008) Jack Kent et al.   PLoS One

cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

(2008) J. S. O'Neill et al.   SCIENCE

Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact

(2008) Douglas A. Bayliss et al.   TRENDS IN PHARMACOLOGICAL SCIENCES