Article
Gastroenterology & Hepatology
Shin Hwang, Deok-Bog Moon, Ki-Hun Kim, Chul-Soo Ahn, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
Summary: This study evaluated the prognostic accuracy of the ADV score in patients with HCC and PVTT, and found that the ADV score is an integrated surrogate biomarker with high prognostic accuracy in predicting tumor recurrence and patient survival under stratification.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Xingmao Zhang, Qiao Wu, Hua Fan, Qiang He, Ren Lang
Summary: This study retrospectively analyzed clinicopathologic data of patients who underwent extensive PD with S-M-P confluence resection for pancreatic head/uncinate process cancer. Results showed that reconstructing S-M-P confluence by bifurcated allogeneic vein after resection may help to avoid left-sided portal hypertension without increased complications, with comparable pathological results, blood loss, and complications between the two groups.
Article
Oncology
Yiwen Qiu, Yi Yang, Tao Wang, Shu Shen, Wentao Wang
Summary: This study investigated the impact of microscopic portal vein invasion (MPVI) on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE). The results showed that PA-TACE had better recurrence-free survival (RFS) and overall survival (OS) outcomes in patients without MPVI. However, for patients with MPVI, PA-TACE did not significantly improve RFS or OS outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biophysics
Hui-Yan Li, Fang-Fei Yin, Xin-Yi Li, Wan-Nan Jia, Jia Ding, Li Zhang, Zhong-Hua Wang, Qin-Qin Hu, Jie-Liang Zuo, Hu-Liang Jia, Li-Hua Wang, Chun-Hai Fan, Hong-Zhou Gu, Jian Wu
Summary: In this study, an aptamer AP32 specific to SHh was obtained by SELEX technology and a novel aptamer-based assay was successfully developed. The method exhibited a broad detection range, high sensitivity, and could be used to predict early metastasis and poor prognosis in HCC, even in AFP-negative cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Gastroenterology & Hepatology
Li-Qing Li, Ying Zhou, Yong Huang, Ping Liang, Shi-Xiong Liang, Ting-Shi Su
Summary: This study compared the long-term outcomes of robotic stereotactic body radiotherapy (SBRT) with intensity-modulated radiotherapy (IMRT) in advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). The results showed no significant difference in overall survival, progression-free survival, intrahepatic control, and local control between SBRT and IMRT groups. SBRT may be a safe and more time-efficient treatment for local advanced HCC with PVTT when high-precision tracking technology is available.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Surgery
Ahmed Shehta, Ahmed Farouk, Ahmed Nabieh Elghawalby, Mohamed Elshobary, Ahmed Aboelenin, Amgad Fouad, Mahmoud Abdelwahab Ali
Summary: The study evaluated the experience of liver resection for hepatocellular carcinoma patients with macroscopic portal vein invasion and found that patients with macroscopic PVI had lower overall survival rates and higher incidence of post-operative morbidities. However, there were no significant differences in terms of recurrence rate and disease-free survival rates between the two groups.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Yongping Zhou, Jitao Wang, Shuang-Lin Zhang, Hao Wang, Yong Yan, Xiumin Qi, Shubo Chen, Fang-Ming Chen
Summary: A risk score model combining radiomics signature and venous deformity was developed to estimate the risk of superior mesenteric-portal vein (SMPV) involvement in patients with pancreatic ductal adenocarcinoma (PDAC) preoperatively.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Dongying Chen, Xiaoyan Cai, Hui Ouyang, Shiwen Yuan, Xiaodong Wang, Lian Lin, Zhiqing Chen, Mingcheng Huang
Summary: In this study, increased expression of eEF2K was found in synovial tissues and FLSs of RA patients. Knockdown or inhibition of eEF2K reduced inflammation, migration/invasion, glucose uptake and lactate productions in RA FLSs. eEF2K knockdown also suppressed the activation of NF-KB and AKT pathways in RA FLSs. Lactate was involved in the inhibitory effect of eEF2K knockdown on inflammation and migration. NH125 treatment attenuated the severity of arthritis in collagen-induced arthritis mice.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Brian Carr, Vito Guerra, Rossella Donghia, Volkan Ince, Sami Akbulut, Veysel Ersan, Sertac Usta, Burak Isik, Emine Samdanci, Sezai Yilmaz
Summary: Background factors like microscopic portal vein invasion (microPVI) and tumor multifocality are important prognostic factors in hepatocellular carcinoma (HCC). This study aimed to investigate the direct relationship between microPVI and multifocality, finding that microPVI had a stronger association with maximum tumor diameter (MTD) and worse survival outcomes in patients with larger HCCs. However, the number of tumor foci did not impact patient survival outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Nil Grunberg, Meirav Pevsner-Fischer, Tal Goshen-Lago, Judith Diment, Yaniv Stein, Hagar Lavon, Shimrit Mayer, Oshrat Levi-Galibov, Gil Friedman, Yifat Ofir-Birin, Li-Jyun Syu, Cristina Migliore, Eyal Shimoni, Salomon M. Stemmer, Baruch Brenner, Andrzej A. Dlugosz, David Lyden, Neta Regev-Rudzki, Irit Ben-Aharon, Ruth Scherz-Shouval
Summary: This study used RNA sequencing of CAFs from gastric cancer patients to identify a stromal gene signature associated with aggressive gastric cancer, with HSF1 playing a key regulatory role in this signature. HSF1 upregulates inhibin subunit beta A and thrombospondin 2, which are secreted in CAF-derived extracellular vesicles to promote cancer progression.
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Hye Won Lee, Yong-Han Paik, Do Young Kim, Yoon Jun Kim, Kang Mo Kim, Si Hyun Bae, Ji Hoon Kim, Yeon Seok Seo, Jae Young Jang, Byoung Kuk Jang, Hyung Joon Yim, Hyung Joon Kim, Byung Seok Lee, Bo Hyun Kim, In Hee Kim, Eun-Young Cho, Jung Il Lee, Kyung-Suk Suh
Summary: Sorafenib is a recommended first-line treatment for HCC patients with PVI, but in clinical practice, there is a wide variety of treatment modalities used as first-line options. This study found that HCC patients with PVI have diverse treatment patterns and outcomes, highlighting the need for subclassification and personalized treatment approaches.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Medicine, Research & Experimental
Houssem Ammar, Nouha Dammak, Mahdi Ben Latifa, Mohamed Amine Said, Marwa Azri, Rahul Gupta, Habiba Ben Hamada, Oussama Belkacem, Mohamed Ben Mabrouk, Ali Ben Ali
Summary: This article describes a case of a 70-year-old female patient who presented with abdominal pain in the right upper quadrant for 6 months. Abdominal CT revealed a large liver hydatid cyst in the right lobe that had ruptured into the right portal vein branch, causing venous thrombosis. Intraoperatively, the right portal vein was opened and the cyst contents were evacuated. Right hepatectomy was performed to remove the cyst completely. The penetration of a cyst into an adjoining vessel is very rare, and portal vein invasion by hydatid disease is extremely rare, with only 10 cases reported in the literature, to the best of our knowledge.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Ming-Feng Li, Huei-Lung Liang, Chia-Ling Chiang, Wei-Lun Tsai, Wen-Chi Chen, Cheng-Chung Tsai, I-Shu Chen
Summary: The new HAIC regimen is effective in treating Vp4 HCC patients, but additional sorafenib use does not provide any survival benefit.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Kaihang Zhong, Yuyan Xu, Yuan Cheng, Yaohong Wen, Lei Cai, Guolin He, Huakun Huang, Shunjun Fu, Xuefeng Zhong, Yating Zheng, Tingting Chen, Mengli Huang, Mingxin Pan
Summary: This study reported a HCC patient with high enrichment of tumor-infiltrating immune cells and tertiary lymphoid structure in the baseline tumor immune microenvironment, who achieved complete response after combined immunotherapy. These findings suggest that the baseline tumor immune microenvironment can be used as a clinical decision-making tool for assisting HCC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhisa Ohgi, Takeshi Aramaki, Akifumi Notsu, Katsuhiko Uesaka
Summary: For pancreatic body and/or tail cancer involving portal vein contact <= 180 degrees, it should be considered borderline resectable due to poor survival.
Article
Surgery
Steffen Deichmann, Uwe Ballies, Ekaterina Petrova, Louisa Bolm, Kim Honselmann, Laura Frohneberg, Tobias Keck, Ulrich Friedrich Wellner, Dirk Bausch
Summary: This study aimed to evaluate independent risk factors for the duration of intensive care unit (ICU) stay after pancreatoduodenectomy (PD). It was found that patients with cardiovascular risk factors and elevated preoperative creatinine level are at greater risk for a prolonged ICU stay. Additionally, antihypertensive medication, operation time, extended LAD, and severe PPH were identified as significant risk factors for longer ICU stay after PD.
ZENTRALBLATT FUR CHIRURGIE
(2022)
Review
Surgery
Miljana Vladimirov, Dirk Bausch, Hubert J. Stein, Tobias Keck, Ulrich Wellner
Summary: This meta-analysis compared the outcomes of hybrid laparoscopic pancreatoduodenectomy and open pancreatoduodenectomy, showing that hybrid laparoscopic surgery had significantly longer operative time but comparable postoperative parameters and major morbidity to open surgery.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Louisa Bolm, Sergii Zemskov, Maria Zeller, Taisuke Baba, Jorge Roldan, Jon M. Harrison, Natalie Petruch, Hiroki Sato, Ekaterina Petrova, Hryhoriy Lapshyn, Ruediger Braun, Kim C. Honselmann, Richard Hummel, Oleksii Dronov, Alexander V. Kirichenko, Monika Klinkhammer-Schalke, Kees Kleihues-van Tol, Sylke R. Zeissig, Dirk Rades, Tobias Keck, Carlos Fernandez-del Castillo, Ulrich F. Wellner, Rodney E. Wegner
Summary: This study assesses perioperative therapy in stage IA-III pancreatic cancer by cross-validating the German Cancer Registry Group and the National Cancer Database. The findings show that combined neoadjuvant and adjuvant therapy improved overall survival compared to either therapy alone.
Article
Surgery
Torben Glatz, Sebastian Brinkmann, Omar Thaher, Jamal Driouch, Dirk Bausch
Summary: Minimally invasive resection techniques for pancreatic pathologies are advantageous but challenging in Germany. The learning curve and surgical volume vary, and the decentralized nature of pancreatic surgery limits the nationwide implementation of robotic pancreatic surgery, with current restriction to high volume centers.
ZENTRALBLATT FUR CHIRURGIE
(2022)
Article
Oncology
Ruediger Braun, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Kees Kleihus van Tol, Louisa Bolm, Kim C. Honselmann, Ekaterina Petrova, Hryhoriy Lapshyn, Steffen Deichmann, Thaer S. A. Abdalla, Benjamin Heckelmann, Peter Bronsert, Sergii Zemskov, Richard Hummel, Tobias Keck, Ulrich F. Wellner
Summary: Adenosquamous carcinoma of the pancreas is a rare malignancy with poorer differentiation and more aggressive tumor biology compared to ductal adenocarcinoma. Patients with adenosquamous carcinoma have shorter survival, especially after surgical resection. Special treatment protocols should be considered for this type of pancreatic cancer.
Article
Medicine, General & Internal
Tim Fahlbusch, Philipp Hoehn, Carsten Klinger, Jens Werner, Tobias Keck, Helmut Friess, Joerg Koeninger, Thomas W. Kraus, Guido Alsfasser, Winfried Padberg, Joerg-Peter Ritz, Waldemar Uhl, Orlin Belyaev
Summary: Delayed gastric emptying (DGE) is a common complication in pancreatic surgery, leading to increased healthcare costs. This study retrospectively evaluated data from 1688 patients who underwent distal pancreatectomy, finding that postoperative pancreatic fistulas, abscesses, and surgical complications were associated with DGE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Markus Kist, Michael Thomaschewski, Yannick Keck, Thaer S. A. Abdalla, Sylke Ruth Zeissig, Kees Kleihues-van Tol, Ulrich Friedrich Wellner, Tobias Keck, Jens Hoeppner, Richard Hummel
Summary: The incidence of early-onset gastric cancer, defined as gastric cancer occurring in young patients, is relatively low. However, this study found that these young patients with gastric cancer have more aggressive tumors and receive less curative treatment compared to elderly patients. Despite these differences, the survival rate of early-onset gastric cancer patients was significantly better, and age was identified as an independent predictor for better survival.
Editorial Material
Oncology
Hendrik Ungefroren, Bjoern Konukiewitz, Ruediger Braun, Ulrich Friedrich Wellner, Tobias Keck, Jens-Uwe Marquardt
Editorial Material
Oncology
Hendrik Ungefroren, Bjoern Konukiewitz, Ulrich F. F. Wellner, Joerg Schrader, Tobias Keck
Article
Surgery
Kim C. Honselmann, Yannic Elser, Tabea Boeckmann, Louisa Bolm, Meike ten Winkel, Steffen Deichmann, Ruediger Braun, Ulrich F. Wellner, Tobias Keck, Hryhoriy Lapshyn
Summary: This multicenter study analyzed the relationship between preoperative symptoms and postsurgical outcomes utilizing the German national DGAV StuDoQ|Pancreas database. The study found that preoperative symptoms were common and associated with overall survival.
Article
Cell Biology
Ruediger Braun, Olha Lapshyna, Jessica Watzelt, Maren Drenckhan, Axel Kuenstner, Benedikt Faerber, Ahmed Ahmed Mohammed Hael, Louisa Bolm, Kim Christin Honselmann, Bjoern Konukiewitz, Darko Castven, Malte Spielmann, Sivahari Prasad Gorantla, Hauke Busch, Jens-Uwe Marquardt, Tobias Keck, Ulrich Friedrich Wellner, Hendrik Ungefroren
Summary: The prognosis of pancreatic ductal adenocarcinoma (PDAC) is very poor, and surgical resection is the only curative treatment option. A study established two new PDAC cell lines, which exhibit distinct molecular phenotypes, providing potential models for researching new treatment strategies and developing personalized therapy regimens.
Article
Gastroenterology & Hepatology
Patricia Marie Doll, Louisa Bolm, Ruediger Braun, Kim C. Honselmann, Steffen Deichmann, Birte Kulemann, Iurii Kuchyn, Sergii Zemskov, Dirk Bausch, Tobias Keck, Ulrich Friedrich Wellner, Hryhoriy Lapshyn
Summary: This study evaluated the impact of perioperative fluid administration on pancreatic surgery and found that high fluid balance is associated with postoperative complications. Restrictive fluid management after surgery is recommended for patients undergoing pancreatic surgery.
Article
Surgery
Jamal Driouch, Omar Thaher, Sebastian Brinkmann, Dirk Bausch, Torben Glatz
Summary: This study utilized the NOSE-RRR technique combined with robotic assistance for rectosigmoid resection rectopexy in patients with obstructive defecation syndrome. The results showed that this technique can be performed safely and has a low rate of complications, providing significant improvement in patients' symptoms.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
