Article
Agriculture, Multidisciplinary
Wenjia He, Oskar Laaksonen, Ye Tian, Tuuli Haikonen, Baoru Yang
Summary: The phenolic profiles and other major metabolites in European pear juices were investigated using UHPLC-DAD-ESI-QTOF-MS and GC-FID. A total of 39 phenolic compounds were detected, and the content variations were mainly dependent on the cultivar. The genetic background and breeding selections also played a role in the chemical compositions. The results provide important information for industry and pear breeding.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Soraia I. Pedro, Tiago A. Fernandes, Angelo Luis, Alexandra M. M. Antunes, Jose C. Goncalves, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: This study evaluated the potential industrial applications of various Acacia species by examining their chemical composition, antioxidant, and antimicrobial properties. Among the studied species, A. pycnantha exhibited a higher concentration of total phenolic compounds and displayed notable antibacterial activity. Vibrational spectroscopy was a reliable method for distinguishing between species.
Article
Chemistry, Applied
Diletta Piatti, Simone Angeloni, Filippo Maggi, Giovanni Caprioli, Massimo Ricciutelli, Lolita Arnoldi, Stefania Bosisio, Giacomo Mombelli, Ettore Drenaggi, Gianni Sagratini
Summary: The polar extracts and essential oils of sea fennel cultivated in central Italy were analyzed. The extracts contained 21 bioactive compounds, with 5-O-caffeoylquinic acid being the most abundant. Melatonin, a hormone that regulates sleep/wake cycle, was identified for the first time in sea fennel extract. The essential oil was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. This study highlights the potential use of sea fennel as an edible plant and a source of nutraceutical compounds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Applied
Christof B. Steingass, Jonas Burkhardt, Vicky Baeumer, Keshav Kumar, Heiko Mibus-Schoppe, Jana Zinkernagel, Patricia Esquivel, Victor M. Jimenez, Ralf Schweiggert
Summary: Anthocyanins were characterized in red cabbage, sweet potato, and Tradescantia pallida leaves. Various non-, mono-, and diacylated cyanidins were identified in red cabbage. Sweet potato leaves contained mono- and diacylated cyanidin- and peonidin glycosides, while T. pallida leaves mainly contained tetra-acylated anthocyanin tradescantin. The thermal stability of red cabbage and purple sweet potato extracts surpassed that of a commercial food dye, but still fell short compared to the stability of Tradescantia extract.
Article
Plant Sciences
Soraia I. Pedro, Tiago Rosado, Celina Barroca, Duarte Neiva, Vanesa Alonso-Herranz, Ana Gradillas, Antonia Garcia, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: Acacia spp. is an invasive species widely distributed in Portugal. It has been found that Acacia flowers contain high concentrations of phenolic compounds and flavonoids. The composition of these compounds varies among different species and flowering stages, and can be distinguished through analysis of FTIR-ATR spectra data of the extracts.
Article
Biochemistry & Molecular Biology
Simon-Okomo Aloo, Fred-Kwame Ofosu, Deog-Hwan Oh
Summary: The study found that sprouts are healthier and more nutritionally rich than raw seeds, with stronger antioxidant, antidiabetic, and antiobesity activities. Sprouting leads to higher levels of metabolites in sprouts compared to raw seeds, making it a suitable technique for altering the functional properties of edible seeds depending on the desired activity.
Article
Chemistry, Applied
Zijian Liang, Pangzhen Zhang, Yun Xiong, Stuart K. Johnson, Zhongxiang Fang
Summary: This study characterized the phenolic and carotenoid profiles of the Australian native bulb plant, Haemodorum spicatum, using HPLC-DAD-ESI-QTOF-MS/MS and HPLC-DAD. The results identified 40 phenolic compounds and 2 carotenoids, with 35 compounds being reported for the first time in H. spicatum.
Article
Plant Sciences
Alessia Mannucci, Marco Santin, Lucas Vanhaelewyn, Maria Calogera Sciampagna, Maria Begona Miras-Moreno, Leilei Zhang, Luigi Lucini, Mike Frank Quartacci, Dominique Van Der Straeten, Antonella Castagna, Annamaria Ranieri
Summary: This study used a metabolomic approach to investigate the metabolic changes in tomato leaves and roots under UV radiation. The study found unexpected modulation of secondary metabolism, particularly the phenylpropanoid pathway, in both leaves and roots. Additionally, the study showed that the modulation at the metabolic and phenolic levels persisted even after the cessation of UV treatment.
Article
Chemistry, Medicinal
Daniel Mendez, Julio C. Escalona-Arranz, Enrique Molina Perez, Kenn Foubert, An Matheeussen, Emmy Tuenter, Ann Cuypers, Paul Cos, Luc Pieters
Summary: Coccoloba cowellii Britton is an endemic and critically endangered plant species with promising antifungal activity, particularly effective against Cryptococcus neoformans and various Candida spp. Its total methanolic extract showed higher and broader antifungal activity compared to its fractions and isolated compounds.
Article
Biochemical Research Methods
Rosa Padilla, Vincent Gaillard, Thao Nhi Le, Floriant Bellvert, David Chapulliot, Xavier Nesme, Yves Dessaux, Ludovic Vial, Celine Lavire, Isabelle Kerzaon
Summary: Opines are low-molecular-weight metabolites specifically synthesized by agrobacteria-transformed plant cells during crown gall and hairy root diseases. A new analytical method using UHPLC-ESI-MS-QTOF was developed for opine detection, showing high sensitivity and specificity across different plant extracts. This method is a powerful tool for plant gall analysis and disease diagnosis, allowing for the detection of various opines in a single run with accurate quantification.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Food Science & Technology
Adrieli Rodrigues da Costa Nunes, Claudete Aparecida Mangolin, Arildo Jose Braz de Oliveira, Regina Aparecida Correia Goncalves, Alexandre da Silva Avincola, Rafaela Takako Ribeiro de Almeida, Eduardo Jorge Pilau, Maria de Fatima Pires da Silva Machado
Summary: The study found that the cladode extract from Cereus peruvianus grown in the southern region of Brazil contains abundant phenolic compounds and antioxidant activity, including flavonoids that have not been reported before. These phenolic compounds linked to antioxidant activities support the use of this species as a source of natural antioxidants in human food.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mirtha Navarro-Hoyos, Elizabeth Arnaez-Serrano, Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper
Summary: This study analyzed the compounds found in Physalis peruviana fruits and husks from Costa Rica using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. A total of 66 different compounds were identified. The results suggest that the husks and fruits of Physalis peruviana from Costa Rica may have potential health benefits.
Article
Chemistry, Analytical
Sasa Savic, Sanja Petrovic, Sanela Savic, Nebojsa Cekic
Summary: This study aimed to identify N-alkylamides from commercial Acmella oleracea extract, assess their UV-B photostability in various solvents, and identify degradation products. The results showed that spilanthol and homospilanthol were the most stable N-alkylamides, while 6,9-dihydroxy-deca-2,7-dienoic acid isobutyl-amide and 8,9-dihydroxy-deca-2,6-dienoic acid isobutyl-amide were identified as the main degradation products in all solutions tested.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Annette Wagner, Stefan Dussling, Stefano Scansani, Peter Bach, Michael Ludwig, Christof B. Steingass, Frank Will, Ralf Schweiggert
Summary: This study investigated the juice production of red-fleshed 'Weirouge' apples using the innovative spiral filter press technology in an oxygen-reduced atmosphere. The results showed that the spiral filter pressed juices had a more brilliant red color and significantly higher amounts of oxidation-sensitive constituents compared to juices produced with conventional systems. The differences in color and phenolic compounds between the juices produced with different pressing systems were maintained during storage, suggesting that the spiral filter press is a promising technology for the production of juices with better color and retention of oxidation-sensitive constituents.
Article
Food Science & Technology
Annette Wagner, Stefan Dussling, Alexander Nowak, Lisa Zimmermann, Peter Bach, Michael Ludwig, Keshav Kumar, Frank Will, Ralf Schweiggert, Christof B. Steingass
Summary: Blackcurrant juices were produced using different pressing systems, including an oxygen-excluding spiral filter press and conventional pressing systems. The study found that the total and individual anthocyanin contents were not significantly different between the two pressing methods. Storage temperature had a strong impact on anthocyanin levels, while the pressing system did not. In a model solution, factors such as sugar content, ascorbic acid content, and pH value had a significant influence on anthocyanin levels during heat treatment.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Critical Care Medicine
Antoine Duclos, Cecile Payet, Loredana Baboi, Bernard Allaouchiche, Laurent Argaud, Frederic Aubrun, Julien Bohe, Frederic Dailler, Jean-Luc Fellahi, Jean-Jacques Lehot, Vincent Piriou, Thomas Rimmele, Delphine Terragrossa, Stephanie Polazzi, Claude Guerin
Summary: This study found that the familiarity level between nurses in the ICU has a significant impact on patient outcomes, with higher familiarity associated with lower risk of patient deaths.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Oncology
Reisya R. R. Riantiningtyas, Florence Carrouel, Amandine Bruyas, Wender L. P. Bredie, Camille Kwiecien, Agnes Giboreau, Anestis Dougkas
Summary: The present review highlights the changes in food perception among head and neck cancer patients, including taste, texture, temperature, and other oral sensations. These changes not only have physiological importance but also convey psychological and psychosocial values. Comprehensive assessment of patients' food perception can lead to personalized dietary interventions to improve their eating experience and quality of life. More studies on oral somatosensory perception with larger sample sizes and standardized assessment methods are needed to fully understand its impact on eating behavior and quality of life.
Article
Cardiac & Cardiovascular Systems
Camelia Acatrinei, Caroline Martin-Bonnet, Gilles Rioufol, Francis Bessiere
Summary: This case report describes a patient with Fontan circulation who developed IART and initial poor haemodynamic tolerance. Both IART ablation and transcatheter aortic valve replacement were performed during the same procedure, resulting in improved haemodynamics and control of the arrhythmia.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Review
Critical Care Medicine
Martin Ruste, Matthias Jacquet-Lagreze, Jean-Luc Fellahi
Summary: Individualized hemodynamic optimization often requires cardiac output monitoring, which can be achieved through noninvasive technologies. Care providers need to be aware of the advantages and limitations of these technologies to ensure appropriate use for patient care.
CURRENT OPINION IN CRITICAL CARE
(2023)
Letter
Endocrinology & Metabolism
Charles Thivolet, Etienne Larger, Bertrand Cariou, Eric Renard, Helene Hanaire, Pierre -Yves Benhamou, Bruno Guerci, Emilie Mathiotte, Karim Chikh
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Amine Fikani, Martin Beaufigeau, Justine Vignon, Benoit Cosset, Ahmad Hayek, Fadi Farhat
Summary: This retrospective study analyzed consecutive patients who underwent surgery for VSR and found that post-operative use of ECLS was associated with more bleeding complications and the need for reintervention. Although mortality was similar, bleeding complications remain a major limitation for the use of ECLS.
JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Article
Clinical Neurology
Stephane Legriel, Rafael Badenes, Nicolas Engrand, Rocio Mendoza-Trujillo, Pauline Soulier, Sarah Benghanem, Michael Pizzi, Carolina Maciel, Jonathan Chelly, Benjamin Zuber, Marie Labruyere, Gaetan Plantefeve, Gwenaelle Jacq, Arnaud Galbois, Yoann Launey, Laurent Argaud, Olivier Lesieur, Alexis Ferre, Marine Paul, Antoine Guillon, Pierre Bailly, Pascal Beuret, Marie-Charlotte de-Carne, Shidasp Siami, Dalila Benzekri, Gwenhael Colin, Leidy Gaviria, Jose Luis Aldana, Cedric Bruel, Annabelle Stoclin, Nicholas Sedillot, Guillaume Geri, Daniel Samano, Evie Sobczak, Emily Swafford, Kristine O'Phelan, Arnaud Meffert, Mathilde Holleville, Stein Silva, Manoel JoseAlves da Costa, Jorge Mejia, Ayham Alkhachroum
Summary: This study aims to report the prevalence and outcomes of acute encephalopathy in patients with severe COVID-19, as well as identify the determinants of 90-day outcomes. The results showed that more than half of COVID-19 patients with acute encephalopathy had poor outcomes, which were associated with factors such as age, comorbidities, impairment of consciousness, and etiology of acute encephalopathy. This highlights the importance of recognizing and managing encephalopathy in COVID-19 patients.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Jeroen Bertels, Patrick Dupont, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: The study aims to investigate the reversibility of diffusion-weighted imaging (DWI) lesions and its association with thrombolysis, reperfusion, and functional outcomes. It found that reversibility of DWI lesions is common in patients from the WAKE-UP trial, and it is more pronounced after thrombolysis.
Article
Food Science & Technology
Carolla El Chamieh, Islam Amine Larabi, Solene M. Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Celine Lange, Benedicte Stengel, Natalia Alencar De Pinho, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: Proton-pump inhibitors (PPIs) are commonly used in patients with chronic kidney disease (CKD), and are associated with the retention of uremic toxins (UTs). In this cross-sectional study, we found that patients using PPIs had higher levels of certain UTs compared to other patients. These findings are important for understanding factors that modulate serum UT concentration in CKD patients.
Article
Oncology
Ferdinand Blangero, Maud Robert, Thomas Andraud, Charles Dumontet, Hubert Vidal, Assia Eljaafari
Summary: Obesity increases the risk of cancer, including breast cancer. This study proposes a new mechanism in which mesenchymal stem cells from obese adipose tissue (ob-ASC) interact with immune cells, leading to inflammation and the activation of pathogenic cells double-secreting IL-17/IFN gamma. This interaction promotes breast cancer progression by enhancing cytokine secretion, angiogenic factor secretion, metalloproteinase expression, immune checkpoint overexpression, and cell migration in breast cancer cells.
Article
Cardiac & Cardiovascular Systems
Stefana Enachi, Maxime Schleef, Chahr-Eddine Hadjseyd, Simon Leboube, Charles Fauvel, Lucie Daniel, Antoine Jobbe-Duval, Laurent Sebbag, Sandrine Lemoine, Nathan Mewton
Summary: Chronic kidney disease (CKD) is common in patients with heart failure and reduced ejection fraction (HFrEF), and it is a major factor contributing to adverse outcomes. Despite limited data, studies have shown that HFrEF therapies continue to be effective in improving cardiovascular outcomes in patients with CKD. Most HF drugs cause acute renal hemodynamic changes, but these changes stabilize or even improve after the acute phase, without long-term deterioration of renal function. This paper challenges the misconceptions about the pathophysiology of HF that hinder the implementation of disease-modifying therapy in this context and proposes a strategy for titrating HF drugs in patients with moderate, severe, and end-stage CKD.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pauline Delage, Berenice Segrestin, Kevin Seyssel, Stephanie Chanon, Aurelie Vieille-Marchiset, Annie Durand, Angeline Nemeth, Sylviane Metairon, Aline Charpagne, Patrick Descombes, Jorg Hager, Martine Laville, Hubert Vidal, Emmanuelle Meugnier
Summary: The adaptive response to overfeeding involves significant changes in gene expression in adipose tissue. This study investigated whether supplementation with polyphenols could affect these molecular adaptations in lean men. The results showed that polyphenol supplementation modulated gene expression in adipose tissue and potentially protected against adipose tissue expansion during weight gain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Critical Care Medicine
Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maite Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stephane Ruckly, Jean-Marie Forel, Jean-Francois Timsit
Summary: Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV-associated-non-AIDS (HANA) conditions] may now be observed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Bani-Sadr, Dylan Pavie, Laura Mechtouff, Matteo Cappucci, Marc Hermier, Roxana Ameli, Laurent Derex, Charles De Bourguignon, Tae-Hee Cho, Omer Eker, Norbert Nighoghossian, Yves Berthezene
Summary: The presence of brush sign is associated with infarct growth after successful thrombectomy, while cerebral collateral status is not.
EUROPEAN RADIOLOGY
(2023)
