Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 37, Issue -, Pages 564-573Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.08.026
Keywords
Citrus; Limonoids; PLGA resomers; Entrapment; qNMR; Nanoparticles; alpha-amylase
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Funding
- USDA-NIFA through Vegetable & Fruit Improvement Center [2010-34402-20875]
- Texas Department of Agriculture [SC-1607-013]
- NIFA [2010-34402-20875, 580867] Funding Source: Federal RePORTER
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To overcome the solubility and bioavailability challenges of nomilin, we have formulated and characterized a nanoparticle-based delivery system. Nomilin nanoparticles were prepared with poly (lactic-co-glycolic acid) (PLGA) resomers of different co-polymer composition and molecular weights with two surfactant, didodecyl dimethyl ammonium bromide (DMAB) and pluronic F-68 (PF-68) at three nomilin loading levels (30%, 40% and 50%) through modified emulsion diffusion evaporation technique. The smallest mean particle sizes, 135-188 nrn, were obtained with DMAB as the surfactant. The PLGA (50:50) polymer exhibited a slow release pattern in all loading levels, except 40% loading with PF-68. Significantly higher in vitro inhibition of alpha-amylase and angiotensin-converting enzyme activity was observed with nomilin-loaded PLGA nanoparticles as compared to pure nomilin. Thus, nomilin nanoparticles can be explored for understanding the various biological properties using in vivo studies. (C) 2017 Elsevier Ltd. All rights reserved.
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