Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Elizabeth L. Norton, Neeraj Chaudhary, Nicholas Burris, Suzuna Shiomi, Karen M. Kim, Himanshu J. Patel, G. Michael Deeb, Bo Yang
Summary: Management of type A aortic dissection complicated by cerebral malperfusion presents a challenge. Patients with internal carotid artery (ICA) occlusion have poor outcomes, while those with common carotid artery (CCA) occlusion or comatose state should not be dismissed for surgery. Prompt neck computed tomography angiography in patients with cerebral malperfusion may be necessary.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Horea Feier, Andrei Grigorescu, Laurentiu Braescu, Lucian Falnita, Marius Sintean, Constantin Tudor Luca, Mihaela Mocan
Summary: The use of the innominate artery for arterial perfusion in type A acute aortic dissection repair leads to better perfusion and superior results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shenghua Liang, Yanxiang Liu, Bowen Zhang, Yaojun Dun, Hongwei Guo, Xiangyang Qian, Xiaogang Sun
Summary: This study aimed to investigate the incidence, risk factors, and outcomes of postoperative hepatic dysfunction (PHD) in patients undergoing frozen elephant trunk (FET) for type A aortic dissection (TAAD). PHD was associated with increased early mortality and morbidity, but not with late death in midterm survival. Preoperative aspartate transferase, celiac trunk malperfusion, and cardiopulmonary bypass time were identified as predictors for PHD, while retrograde perfusion was associated with reduced risk of PHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Manabu Yamasaki, Hideaki Yoshino, Takashi Kunihara, Koichi Akutsu, Tomoki Shimokawa, Hitoshi Ogino, Mitsuhiro Kawata, Toshiyuki Takahashi, Michio Usui, Kazuhiro Watanabe, Hiroshi Masuhara, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
Summary: This study found that male sex, use of percutaneous circulatory assist devices, shock, cardiac and cerebral ischemia are independent preoperative risk factors for early mortality after acute type A aortic dissection repair, while cardiac tamponade, cerebral and mesenteric ischemia are independent postoperative risk factors.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ibrahim Sultan, Valentino Bianco, Himanshu J. Patel, George J. Arnaoutakis, Marco Di Eusanio, Edward P. Chen, Bradley Leshnower, Thoralf M. Sundt, Udo Sechtem, Daniel G. Montgomery, Santi Trimarchi, Kim A. Eagle, Thomas G. Gleason
Summary: Fifteen percent of patients with Type A aortic dissection presented with cerebral malperfusion and neurological deficits. Despite being older and more likely to have peripheral malperfusion, cardiac tamponade, and in shock, nearly 75% of these patients survived in-hospital. Surgeons may continue to offer life-saving surgery for Type A aortic dissection to this critically ill cohort with acceptable morbidity and mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Katrin Meisenbacher, Matthias Hagedorn, Denis Skrypnik, Samuel Kilian, Dittmar Boeckler, Moritz S. Bischoff, Andreas S. Peters
Summary: This study aimed to investigate the clinical and morphological outcomes of using a TEVAR-first policy for the treatment of complicated TBAD with LLI. The results suggest that a TEVAR-first strategy is a reasonable approach for managing TBAD with LLI, and morphological parameters can be used to predict the failure of TEVAR alone.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Jean-Francois Aita, Thibault Agripnidis, Benoit Testud, Pierre-Antoine Barral, Alexis Jacquier, Anthony Reyre, Ammar Alnuaimi, Nadine Girard, Farouk Tradi, Paul Habert, Vlad Gariboldi, Frederic Collart, Axel Bartoli, Jean-Francois Hak
Summary: This study summarizes local experience with carotid stenting in patients with type A aortic dissections and cerebral malperfusion, and provides a systematic review on the use of carotid stenting before or after aortic surgery. Although preoperative carotid stenting appears to be feasible, effective, and safe for hemodynamic cerebral malperfusion, there is still a lack of comparative statistical analysis and limited evidence due to the growing but limited literature. Prospective comparative studies are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medical Laboratory Technology
Suwei Chen, Chenhan Zhang, Yongliang Zhong, Bing Tang, Qiang Xie, Rutao Guo, Zhiyu Qiao, Chengnan Li, Yipeng Ge, Junming Zhu
Summary: The study found a correlation between preoperative serum myoglobin concentrations and AKI after TAAD surgery, and high concentrations of serum myoglobin increased the risk of developing any-stage and severe AKI. This finding is significant for the prevention and treatment of AKI after TAAD surgery.
CLINICA CHIMICA ACTA
(2023)
Article
Surgery
Abdul Kader Natour, Ali Rteil, Alexander Shepard, Mitchell Weaver, Timothy Nypaver, Hassan Nemeh, Daizo Tanaka, Loay Kabbani
Summary: This study aimed to examine the outcomes of patients with acute type A aortic dissection (ATAD) and concomitant lower extremity malperfusion. The study found that proximal repair resolved most cases of associated lower limb ischemia (ALLI), and isolated ALLI did not affect short- or long-term survival.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Gemelli, Ettorino Di Tommaso, Roberto Natali, Lauren Kari Dixon, Eltayeb Mohamed Ahmed, Cha Rajakaruna, Vito D. Bruno
Summary: The GERAADA score, particularly the Clinical-GERAADA score, performs better than EuroSCORE II in predicting operative mortality for TAAAD. Further validation of the new malperfusion criteria is necessary.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Mohammed Al-Tawil, Mohamed Salem, Christine Friedrich, Shirin Diraz, Alexandra Broll, Najma Rezahie, Jan Schoettler, Nora de Silva, Thomas Puehler, Jochen Cremer, Assad Haneya
Summary: The study found that ATAAD patients with PSCM have worse postoperative outcomes and poorer long-term survival, highlighting the importance of early recognition and tailored management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Toshihito Gomibuchi, Tatsuichiro Seto, Kazuki Naito, Shuji Chino, Toru Mikoshiba, Masaki Komatsu, Haruki Tanaka, Hajime Ichimura, Takateru Yamamoto, Ko Nakahara, Noburo Ohashi, Megumi Fuke, Yuko Wada, Kenji Okada
Summary: The study identified occlusion or severe stenosis of supra-aortic branch vessels as a predictor of PND risk in patients undergoing surgery for acute type A aortic dissection. Early reperfusion and extra-anatomic revascularization may reduce the risk of neurological complications in patients with ICM, with or without neurological symptoms.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Guang Tong, Jinlin Wu, Zerui Chen, Donglin Zhuang, Shuang Zhao, Yaorong Liu, Yongchao Yang, Zhichao Liang, Ruixin Fan, Zhongchan Sun, Tucheng Sun
Summary: This study investigated the incidence, management, and outcomes of coronary malperfusion (CM) secondary to acute type A aortic dissection (ATAAD) and proposed a modified Neri classification. The study found that the occurrence rate of CM may be more frequent than previously reported. Surgical management based on lesion classification achieved acceptable outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Emergency Medicine
Yuhei Uriu, Akira Kuriyama
Summary: Acute aortic dissection (AD) is a life-threatening emergency with chest pain as the most common symptom, though rare symptoms like monoplegia can also occur. This study presented a case of transient monoplegia caused by Stanford type-B AD, highlighting the importance of considering AD in patients presenting with monoplegia or other transient symptoms in the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Peng-fei Huang, Yun-jing Zhang, Xian-zhe Lou, Dong Ma, Yun-yan Wu, Yong-bo Zhao
Summary: Acute Stanford type A aortic dissection (ATAAD) is a life-threatening condition that requires urgent treatment. This study evaluated the prognostic value of CO2 combining power (CO2CP) combined with serum sodium levels in ATAAD patients. The combination of CO2CP and serum sodium showed a higher predictive value for death and adverse events in ATAAD patients compared to each single indicator. Patients with low CO2CP and high serum sodium had the worst prognosis. The combination of CO2CP and serum sodium can enhance the predictive value of prognosis in ATAAD patients.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Denis A. Berdajs, Luca Koechlin, Gregory Reid, Flurin Grob, Brigitta Gahl, Ulrich Schurr, Oliver Reuthebuch, Friedrich Eckstein
Summary: This study evaluated the efficacy of the modified frozen elephant trunk (mFET) procedure compared to the standard approach in the treatment of DeBakey type I aortic dissection. The results showed that mFET may be considered as a viable alternative with beneficial mid-term outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Maks Mihalj, Paul Philipp Heinisch, Patrick Schober, Monika Wieser, Michele Martinelli, Theo M. M. H. de By, Joerg C. Schefold, Markus M. Luedi, Alexander Kadner, Thierry Carrel, Paul Mohacsi, Lukas Hunziker, David Reineke
Summary: This study compared the midterm outcomes of HeartMate3 (HM3) and HeartWare HVAD (HW) continuous-flow left ventricular assist devices (CF-LVADs). The study found that patients with HeartWare HVAD had a significantly higher risk of device malfunctions, but there were no significant differences between the two devices in terms of overall survival and most outcomes.
Article
Medicine, Research & Experimental
Julia Riggauer, Daniela Blaser, Olgun Elicin, Brigitta Gahl, Roland Giger, Simon Andreas Mueller
Summary: Fear of recurrence is present in head and neck cancer survivors, and it is associated with female sex, younger age, and a history of past recurrence or second primary malignancy.
Review
Cardiac & Cardiovascular Systems
Marius Reto Bigler, Alexander Kadner, Lorenz Raeber, Afreed Ashraf, Stephan Windecker, Matthias Siepe, Massimo Antonio Padalino, Christoph Graeni
Summary: Anomalous coronary arteries originating from the opposite sinus of Valsalva (ACAOS) present challenges in terms of anatomy and clinical manifestations. The increasing use of noninvasive anatomical imaging has resulted in higher detection rates. Lack of evidence-based guidelines leaves treating physicians uncertain about optimal management. Thorough anatomical and hemodynamic assessments are necessary to determine whether ACAOS is a coincidental finding, responsible for symptoms, or a risk for sudden cardiac death. Recent clinical data suggest that myocardial ischemia depends on anatomic high-risk features, influencing treatment decisions. This review discusses the advantages and limitations of surgical, interventional, and medical therapies based on ACAOS anatomy and pathophysiology, proposing a therapeutic management algorithm.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biotechnology & Applied Microbiology
Constantin Mork, Raphael Twerenbold, Brigitta Gahl, Friedrich Eckstein, Raban Jeger, Christoph Kaiser, Oliver Reuthebuch
Summary: Transapical transcatheter aortic valve implantation (TA-TAVI) has similar long-term survival rates but lower incidence of bleeding compared with transfemoral transcatheter aortic valve implantation TAVI (TF-TAVI), despite higher perioperative risk.
BIOENGINEERING-BASEL
(2023)
Article
Cardiac & Cardiovascular Systems
Fabio Pregaldini, Hannah Widenka, Mohamed Barghout, Christoph Grani, Martin Czerny, Fabian A. Kari, Salome Chikvatia, Alexander Kadner, Matthias Siepe
Summary: The study aimed to describe the outcomes of surgical correction for AAOCA in terms of symptom relief. The results showed that most patients experienced significant improvement in symptoms after AAOCA correction.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Surgery
Sebastian Haack, Steven Mann, Brigitta Gahl, Martin Haug
Summary: Reducing postoperative strain on the patient after rhinoplasty is important, and using drains to remove blood from under the dissected soft tissue envelope can effectively decrease ecchymosis, edema, and swelling. Our study showed a significant reduction in ecchymosis on day 2 and 14 after surgery (p = 0.006 and p = 0.017) and a significant effect for edema and general swelling on day 2 (p = 0.027 and p = 0.004). Drains in open rhinoplasty with wide degloving are an easily applicable, cheap, and reproducible approach to reduce postoperative ecchymosis, edema, and swelling, although long-term effects need further evaluation.
FACIAL PLASTIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Max Wagener, Oliver Reuthebuch, Dik Heg, David Tuller, Enrico Ferrari, Jurg Grunenfelder, Christoph Huber, Igal Moarof, Olivier Muller, Fabian Nietlispach, Stephane Noble, Marco Roffi, Maurizio Taramasso, Christian Templin, Stefan Toggweiler, Peter Wenaweser, Stephan Windecker, Stefan Stortecky, Raban Jeger
Summary: This study compares the mortality rates of different types of severe aortic stenosis (high-gradient, classical low-flow low-gradient, and paradoxical low-flow low-gradient) after transcatheter aortic valve implantation. The results show that patients with paradoxical low-flow low-gradient aortic stenosis have lower mortality rates than patients with classical low-flow low-gradient, but higher mortality rates than those with high-gradient.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Constantin Mork, Brigita Gahl, Friedrich Eckstein, Denis A. Berdajs
Summary: This study evaluated the correlation between patient characteristics, operative variables, and the risk of bloodstream infection, as well as the association of primary bloodstream infection with adverse outcomes. The clinical records of 6500 adult patients who underwent open heart surgery between February 2008 and October 2020 were analyzed to evaluate the microbiological pattern of primary bloodstream infection and its association with adverse events such as mortality and major cardiovascular events.
Article
Endocrinology & Metabolism
Judith Everts-Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This registry-based study compared the anti-fracture effectiveness of denosumab and bisphosphonates in patients with osteoporosis. Denosumab showed significantly greater risk reduction for vertebral and any fractures compared to alendronate or ibandronate, while no difference in fracture risk reduction was found between zoledronate and denosumab.
OSTEOPOROSIS INTERNATIONAL
(2023)
Correction
Endocrinology & Metabolism
Judith Everts-Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJoerg Hauselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Nerea Lopez Perez, Philippe Reymond, Mustafa Cikirikcioglu, Mathieu van Steenberghe, Tornike Sologashvili, Nicolas Murith, Thomas Perneger, Christoph Huber
Summary: This study examines the ratio between ascending and descending aorta diameters as a potential surrogate marker for decision making in cases of ascending aortic dilatation. A retrospective observational cohort study was conducted on 50 patients who underwent surgery for acute type A aorta dissection. The results suggest that the ratio between descending and ascending aorta diameters may be a useful tool for stratifying the risk of dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJorg Hauselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study analyzed the incidence of atypical femoral fractures (AFFs) in patients taking denosumab therapy and found that the risk of AFFs is low in patients receiving denosumab, with most AFF patients having prior exposure to BPs.
Meeting Abstract
Pediatrics
Martin Schweiger, Tigba Erdil, Stefano DiBernardo, Christian Balmer, Murat Yildiz, Alexander Kadner
PEDIATRIC TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Paul Philipp Heinisch, Maks Mihalj, Elif Haliguer, Brigitta Gahl, Bernhard Winkler, Philipp Venetz, Hansjoerg Jenni, Patrick Schober, Gabor Erdoes, Markus M. Luedi, Joerg C. Schefold, Alexander Kadner, Christoph Huber, Thierry P. Carrel
Summary: This study analyzed the perioperative morbidity and mortality in adult patients undergoing reoperations for isolated CABG using either CECC or MiECC circuits. The results showed that MiECC can be an alternative strategy for redo-CABG, and there were no significant differences in most outcomes compared to CECC.
SWISS MEDICAL WEEKLY
(2022)