☆ 4.5 Editorial Material

Progress of research on microRNAs with diagnostic value in asbestos exposure: A call for method standardization

BIOSCIENCE TRENDS (2017)

Journal

BIOSCIENCE TRENDS

Volume 11, Issue 1, Pages 105-109

Publisher

IRCA-BSSA

DOI: 10.5582/bst.2016.01249

Keywords

Asbestos; mesothelioma; microRNA; mesomiRs; molecular pathological epidemiology

Categories

Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs with a well-established diagnostic role in cancer and pollution exposure. In a recent systematic review and qualitative meta-analysis followed by a functional investigation, we examined all the available data on the miRNA biomarkers involved in asbestos exposure and MM pathways. This invited commentary aims to provide an insightful critique into the state of the art of the research into clinically relevant miRNA biomarkers, highlighting the strengths and weaknesses of current research efforts in this field. It also reviews the suggestions advanced to improve biomarker development productivity and the translation of research results into clinical practice, stressing that multicenter multidisciplinary studies adopting standardized methods and protocol sharing are the key to move from the workbench to the clinic.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Oncology

Epidemiology and Clinical Aspects of Malignant Pleural Mesothelioma

Fraser Brims

Summary: Mesothelioma is a cancer of the lining of the lungs caused by breathing in asbestos fibres, which remains a challenge in terms of treatment and has an uncertain survival time. The disease mainly occurs in males, with a clear risk associated with exposure to asbestos. There have been significant advances in diagnosis, but further research and treatment are still needed.

CANCERS (2021)

Add to Collection

Article Biology

Mesothelioma mortality within two radiation monitored occupational cohorts

Michael T. Mumma, Jennifer L. Sirko, John D. Boice, William J. Blot

Summary: This study examined the risk of mesothelioma in two cohorts of workers exposed to ionizing radiation. The results showed an increased risk of mesothelioma among shipyard and nuclear power plant workers, suggesting that asbestos exposure rather than low-dose occupational radiation was the main cause for the elevated rate of mesothelioma in these workers.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Incidence of mesothelioma in young people and causal exposure to asbestos in the Italian national mesothelioma registry (ReNaM)

Alessandro Marinaccio, Davide Di Marzio, Carolina Mensi, Dario Consonni, Carmela Gioscia, Enrica Migliore, Carlo Genova, Roberta Rossetto Giaccherino, Silvia Eccher, Stefano Murano, Vera Comiati, Veronica Casotto, Corrado Negro, Lucia Mangone, Lucia Miligi, Sara Piro, Alessia Angelini, Iolanda Grappasonni, Gabriella Madeo, Ilaria Cozzi, Laura Ancona, Tommaso Staniscia, Francesco Carrozza, Domenica Cavone, Luigi Vimercati, Michele Labianca, Federico Tallarigo, Giuseppe Cascone, Massimo Melis, Michela Bonafede, Alberto Scarselli, Alessandra Binazzi

Summary: Mesothelioma incidence surveillance and individual research on asbestos exposure are important for monitoring health effects and preventing exposure risks. Young mesothelioma cases with non-occupational asbestos exposure signal potential clusters of cases.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2023)

Add to Collection

Article Health Care Sciences & Services

Diagnostic and Prognostic Value of Three microRNAs in Environmental Asbestiform Fibers-Associated Malignant Mesothelioma

Veronica Filetti, Carla Loreto, Luca Falzone, Claudia Lombardo, Emanuele Cannizzaro, Sergio Castorina, Caterina Ledda, Venerando Rapisarda

Summary: This study aimed to validate the diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p in MM patients exposed to FE. Results showed the down-regulation of these miRNAs in MM cases, with hsa-miR-323a-3p and hsa-miR-20b-5p having diagnostic value for MM. Computational analysis suggested a potential prognostic role of hsa-miR-101-3p in MM patients, correlating higher expression with increased overall survival.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Add to Collection

Article Respiratory System

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

Job P. van Kooten, Robert A. Belderbos, Jan H. von der Thusen, Mieke J. Aarts, Cornelis Verhoef, Jacobus A. Burgers, Paul Baas, Arend G. J. Aalbers, Alexander P. W. M. Maat, Joachim G. J. Aerts, Robin Cornelissen, Eva V. E. Madsen

Summary: The incidence of malignant mesothelioma in the Netherlands is declining, especially in male patients under 80 years old. The use of systemic chemotherapy has increased since 2003, which may contribute to improved overall survival. However, the majority of patients do not receive antitumor treatment, and prognosis remains poor.

THORAX (2022)

Add to Collection

Review Oncology

Molecular Pathways in Peritoneal Mesothelioma: A Minireview of New Insights

Francesco Fortarezza, Federica Pezzuto, Andrea Marzullo, Domenica Cavone, Daniele Egidio Romano, Antonio d'Amati, Gabriella Serio, Luigi Vimercati

Summary: Mesothelioma is a rare malignant neoplasm with poor survival, primarily affecting the pleura and associated with asbestos exposure. Recent research has focused on identifying molecular pathways and prognostic factors in peritoneal mesothelioma, with implications for diagnosis and treatment.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Medicine, Research & Experimental

KRAS signaling in malignant pleural mesothelioma

Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos

Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.

EMBO MOLECULAR MEDICINE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Microbiomes, Epigenomics, Immune Response, and Splicing Signatures Interplay: Potential Use of Combination of Regulatory Pathways as Targets for Malignant Mesothelioma

Botle Precious Setlai, Zilungile Lynette Mkhize-Kwitshana, Ravi Mehrotra, Thanyani Victor Mulaudzi, Zodwa Dlamini

Summary: Malignant mesotheliomas are difficult-to-treat cancers with poor prognosis, particularly in Sub-Saharan African countries. Exposure to asbestos fibers and lack of regulatory frameworks contribute to the increasing burden of this disease. Epigenetic alterations induced by asbestos and microbiome-epigenetic interactions play crucial roles in the initiation and progression of malignant mesotheliomas. The potential use of epigenetic changes and microbiota as biomarkers and the advancement of combinatorial therapies are discussed for early detection and improved survival of patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Respiratory System

Global, Regional, and National Burden of Mesothelioma 1990-2019 A Systematic Analysis of the Global Burden of Disease Study 2019

Jonghoon Han, Seoyeon Park, Dong Keon Yon, Seung Won Lee, Wongi Woo, Elena Dragioti, Ai Koyanagi, Louis Jacob, Karel Kostev, Joaquim Radua, Sungsoo Lee, Jae Il Shin, Lee Smith

Summary: Mesothelioma has become a major health burden worldwide due to its link with asbestos exposure. Despite bans on asbestos in many countries, the disease continues to cause significant mortality and morbidity. This study assessed the global burden of mesothelioma from 1990 to 2019 and found decreasing incidence and mortality rates, although it remains a public health challenge in many parts of the world.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Mesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case-control study in the USA, 1975-1980

Jason Y. Y. Wong, Carol Rice, Aaron Blair, Debra T. Silverman

Summary: The study found that exposure to both long and short chrysotile fibers increased the risk of mesothelioma compared to no exposure. The highest risk was associated with a complex mixture of extra-long amosite, short and long chrysotile, tremolite and anthophyllite fibers.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2021)

Add to Collection

Article Environmental Sciences

Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma

Suresh Moolgavkar, Ellen T. Chang, E. Georg Luebeck

Summary: The current understanding is that cancer is caused by mutations in a few crucial genes, which has implications for the epidemiology of cancer. These include the impact of age on cancer risk, the role of inherited tumor predisposition syndromes, and the interaction of genetics and environmental exposures on cancer risk.

ENVIRONMENTAL RESEARCH (2023)

Add to Collection

Article Multidisciplinary Sciences

HMGB1 released by mesothelial cells drives the development of asbestos- induced mesothelioma

Joelle S. Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Jin-Hee Kim, Alicia A. Zolondick, Jiaming Xue, Ronghui Xu, Mai Saito, Sandra Pastorino, Michael Minaai, Yasutaka Takanishi, Mitsuru Emi, Ian Pagano, Andrew Wakeham, Thorsten Berger, Harvey I. Pass, Giovanni Gaudino, Tak W. Mak, Michele Carbone, Haining Yang

Summary: Asbestos is found to be the main cause of malignant mesothelioma, and HMGB1 plays a crucial role in its development. HMGB1 is mainly released by mesothelial cells during the early stages of inflammation after asbestos exposure, leading to an inflammatory response and atypical mesothelial hyperplasia. Knocking out HMGB1 in mesothelial cells significantly reduces the inflammatory response and the incidence of mesothelioma.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Add to Collection

Article Environmental Sciences

Industry, occupation, and exposure history of mesothelioma patients in the US National Mesothelioma Virtual Bank, 2006-2022

Yuhe Gao, Jacek M. Mazurek, Yaming Li, David Blackley, David N. Weissman, Shirley V. Burton, Waqas Amin, Douglas Landsittel, Michael J. Becich, Ye Ye

Summary: This study examines the work histories and survival time of patients with suspected exposure to asbestos. The most frequent cases of mesothelioma occurred in patients working in manufacturing, construction, and education services. Males or individuals over 40 tended to work in traditionally asbestos-associated industries, while females or individuals aged 20-40 tended to work in non-traditionally associated industries. The results highlight the importance of considering all potential sources of asbestos exposure when evaluating mesothelioma patients.

ENVIRONMENTAL RESEARCH (2023)

Add to Collection

Article Oncology

Asbestos Lung Burden Does Not Predict Survival in Malignant Pleural Mesothelioma: A Necropsy-Based Study of 185 Cases

Pietro Gino Barbieri, Dario Consonni, Anna Somigliana

Summary: The study found no significant relationship between asbestos lung burden and survival, with histologic subtype being the strongest prognostic determinant.

JOURNAL OF THORACIC ONCOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update

Phillip Munson, Arti Shukla

Summary: This review summarizes the role of exosomes in the development of malignant mesothelioma (MM), and discusses their potential in detection and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Nutrition & Dietetics

Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia

Olga Protic, Raffaele Di Pillo, Alberto Montesanto, Roberta Galeazzi, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Felicia Gurau, Andrea Silvestrini, Fabiola Olivieri, Roberto Antonicelli, Anna Rita Bonfigli

Summary: The evaluated nutraceutical combination did not significantly affect serum lipid profile and inflammatory parameters.

NUTRIENTS (2022)

Add to Collection

Letter Clinical Neurology

Association of admission serum levels of neurofilament light chain and in-hospital mortality in geriatric patients with COVID-19

Francesca Marchegiani, Rina Recchioni, Fiorella Marcheselli, Mirko Di Rosa, Jacopo Sabbatinelli, Giulia Matacchione, Angelica Giuliani, Deborah Ramini, Pierpaolo Stripoli, Leonardo Biscetti, Giuseppe Pelliccioni, Riccardo Sarzani, Francesco Spannella, Antonio Cherubini, Andrea Corsonello, Antonio Domenico Procopio, Anna Rita Bonfigli, Massimiliano Bonafe, Fabrizia Lattanzio, Fabiola Olivieri

JOURNAL OF NEUROLOGY (2023)

Add to Collection

Article Cell Biology

Antifragility and antiinflammaging: Can they play a role for a healthy longevity?

Fabiola Olivieri, Francesco Prattichizzo, Fabrizia Lattanzio, Anna Rita Bonfigli, Liana Spazzafumo

Summary: One of the challenges in aging research is to understand how genetics and environmental factors interact to determine the chances of reaching extreme human lifespan in good health. Epigenetic mechanisms provide an explanation for this interaction and the long-term effects of lifestyle on aging. The theory of inflammaging suggests that chronic low-grade inflammation plays a crucial role in age-related diseases and mortality. Studies on centenarians have shown that healthy individuals can upregulate anti-inflammatory responses to cope with inflammaging. Genetic factors and the ability to remodel metabolic pathways are also important for healthy aging. The concept of antifragility, which refers to the ability of complex systems to perform better under stress, may provide insights into the heterogeneous nature of the aging process and its relationship with inflammation.

AGEING RESEARCH REVIEWS (2023)

Add to Collection

Article Cell Biology

Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells

Angelica Giuliani, Maria Giulia Bacalini, Deborah Ramini, Emanuela Mensa, Chiara Giordani, Luciano Xumerle, Paolo Garagnani, Fabiola Olivieri, Antonio Domenico Procopio, Maria Rita Rippo, Jacopo Sabbatinelli

Summary: Bone marrow mesenchymal stromal cells (BMSCs) have the ability to self-renew and differentiate into adipocytes and osteoblasts, but the role of DNA methylation in their function and replicative senescence is still unclear. A genome-wide DNA methylation analysis revealed genome-wide hypomethylation and overlapping differentially methylated positions (DMPs) in replicative senescent BMSCs and HUVECs. Pathway analysis identified common pathways associated with senescence, insulin resistance, molecule adhesion, and Wnt/beta-catenin signaling. This study provides valuable insights into the mechanisms of replicative senescence and BMSC differentiation.

CELLS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells

Angelica Giuliani, Jacopo Sabbatinelli, Stefano Amatori, Laura Graciotti, Andrea Silvestrini, Giulia Matacchione, Deborah Ramini, Emanuela Mensa, Francesco Prattichizzo, Lucia Babini, Domenico Mattiucci, Elena Marinelli Busilacchi, Maria Giulia Bacalini, Emma Espinosa, Fabrizia Lattanzio, Antonio Domenico Procopio, Fabiola Olivieri, Antonella Poloni, Mirco Fanelli, Maria Rita Rippo

Summary: This study found that the expression of MeCP2 protein is downregulated during adipogenic differentiation of hBMSCs. This downregulation is not dependent on MeCP2 DNA methylation or mRNA levels, but on miRNA regulation. miR-422a and miR-483-5p are upregulated during adipogenic differentiation of hBMSCs. Modulation of miR-422a and miR-483-5p levels can affect MeCP2 expression and adipogenic differentiation.

CELLULAR AND MOLECULAR LIFE SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases

Luigina Micolucci, Giulia Matacchione, Maria Cristina Albertini, Massimo Marra, Deborah Ramini, Angelica Giuliani, Jacopo Sabbatinelli, Antonio Domenico Procopio, Fabiola Olivieri, Annalisa Marsico, Vladia Monsurro

Summary: The nuclear factor NF-kB plays a key role in inflammation by regulating the expression of pro-inflammatory genes. It also has the ability to activate non-coding RNA, such as miRNAs, which further modulate gene expression. In this study, we predicted miRNA promoters using in silico analysis and identified 68 mature miRNAs with potential NF-kB binding sites in their transcription start site. These miRNAs have previously been associated with inflammation and age-related diseases. The results suggest that persistent activation of NF-kB may disrupt the transcription of specific inflammation-related miRNAs, providing potential diagnostic, prognostic, and therapeutic targets for common inflammatory and age-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance

Emanuele-Salvatore Scarpa, Chiara Giordani, Antonella Antonelli, Massimiliano Petrelli, Giancarlo Balercia, Francesca Silvetti, Alessio Pieroni, Jacopo Sabbatinelli, Maria Rita Rippo, Fabiola Olivieri, Giulia Matacchione

Summary: This study aimed to investigate the therapeutic effects of flavanones naringenin and hesperetin in combination with anti-inflammatory natural molecules curcumin, polydatin, and quercetin in in vitro models of insulin resistance. The results showed that the combination of these five phytochemicals synergistically decreased expression levels of the pro-inflammatory gene SEMA3E in insulin-resistant cells and synergistically decreased DPPIV activity, indicating their ability to inhibit pro-inflammatory and insulin resistance molecular mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells

Chiara Giordani, Giulia Matacchione, Angelica Giuliani, Debora Valli, Emanuele Salvatore Scarpa, Antonella Antonelli, Jacopo Sabbatinelli, Gilberta Giacchetti, Sofia Sabatelli, Fabiola Olivieri, Maria Rita Rippo

Summary: During aging, bone marrow mesenchymal stromal cells (MSCs) undergo cellular senescence and acquire a pro-inflammatory secretory phenotype, leading to osteoporosis. In this study, the combination of orthosilicic acid (OA) and vitamin K2 (VK2), along with three anti-inflammatory compounds (curcumin, polydatin, and quercetin) showed potential in promoting MSC osteogenesis and inhibiting their pro-inflammatory phenotype. These natural compounds could be used as a supplement to prevent or control age-related osteoporosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Cell Biology

Sex/gender-related differences in inflammaging

Fabiola Olivieri, Francesca Marchegiani, Giulia Matacchione, Angelica Giuliani, Deborah Ramini, Francesca Fazioli, Jacopo Sabbatinelli, Massimiliano Bonafe

Summary: Geroscience regards aging as a key factor in age-related diseases, emphasizing the need to address the basic mechanisms of aging rather than individual disease pathophysiology. Women have higher life expectancy despite greater functional impairment, necessitating a study of gender-related differences in multimorbidity and disability-free life expectancy. Inflammaging, the intersection of aging and age-related diseases, plays a significant role, with sex/gender differences impacting biomarkers and severe outcomes of COVID-19.

MECHANISMS OF AGEING AND DEVELOPMENT (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Effect of Sphingomyelinase-Treated LDLs on HUVECs

Angelica Giuliani, Camilla Morresi, Gabriele Mazzuferi, Luisa Bellachioma, Deborah Ramini, Jacopo Sabbatinelli, Fabiola Olivieri, Tiziana Bacchetti, Gianna Ferretti

Summary: Low-density lipoproteins (LDLs) play a crucial role in transporting cholesterol to tissues and their oxidative modification is a major risk factor for atherogenesis. This study aimed to investigate the effect of sphingomyelinase (SMase) treatment on LDL properties and its impact on human umbilical vein endothelial cells (HUVECs). The results showed that both ox-LDLs and SMase-LDLs increased intracellular reactive oxygen species (ROS) and upregulated the antioxidant enzyme Paraoxonase 2 (PON2). However, only SMase-LDLs induced the activation of the feedback loop enzyme superoxide dismutase 2 (SOD2) to counteract the detrimental effects of ROS. Furthermore, SMase-LDLs had a stronger pro-apoptotic and proinflammatory effect on HUVECs compared to ox-LDLs.

MOLECULES (2023)

Add to Collection

Article Biology

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Giulia Matacchione, Vittoria Borgonetti, Deborah Ramini, Andrea Silvestrini, Marta Ojetti, Nicoletta Galeotti, Fabiola Olivieri

Summary: Aging is associated with inflammaging, a low-grade and sterile inflammation that is recognized as the main risk factor for age-related diseases. In this study, an Asian-native Ginger extract was found to have anti-senescence and anti-inflammatory properties on human endothelial cells and murine microglial cells, suggesting its potential relevance in delaying age-related diseases.

BIOLOGY-BASEL (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation

Angelica Giuliani, Anna Maria Giudetti, Daniele Vergara, Laura Del Coco, Deborah Ramini, Sara Caccese, Matilde Sbriscia, Laura Graciotti, Gianluca Fulgenzi, Luca Tiano, Francesco Paolo Fanizzi, Fabiola Olivieri, Maria Rita Rippo, Jacopo Sabbatinelli

Summary: Cellular senescence is closely linked to endothelial dysfunction, resulting in chronic inflammation and vascular impairments. The metabolic behavior of senescent endothelial cells is complex and plays a role in the proinflammatory phenotype.

ANTIOXIDANTS (2023)

Add to Collection

Review Geriatrics & Gerontology

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Sergio Giunta, Shijin Xia, Giuseppe Pelliccioni, Fabiola Olivieri

Summary: Inflammaging refers to a chronic proinflammatory state that is associated with age-related diseases. While the focus has been on proinflammatory stimuli, the role of endogenous anti-inflammaging mechanisms has been overlooked. Imbalances in the autonomic nervous system and the hypothalamic-pituitary-adrenal axis contribute to inflammaging, while the cholinergic anti-inflammatory pathway plays a role in reducing inflammation. These mechanisms become less effective in older individuals, contributing to inflammaging.

GEROSCIENCE (2023)

Add to Collection

Review Medicine, Research & Experimental

The prognostic effects of circulating myeloid-derived suppressor cells in non-small cell lung cancer: systematic review and meta-analysis

Giuseppe Bronte, Luana Calabro, Fabiola Olivieri, Antonio Domenico Procopio, Lucio Crino

Summary: Immunotherapy is the main standard treatment for NSCLC patients. However, immune suppressive cells in the tumor microenvironment can counteract its efficacy. This systematic review and meta-analysis aimed to compare the prognosis between NSCLC patients with high and low levels of circulating MDSCs. The findings suggest that low levels of circulating MDSCs are associated with better progression-free survival (PFS)/recurrence-free survival (RFS) and overall survival (OS). Specifically, high levels of monocytic MDSCs (M-MDSCs) in peripheral blood are linked to a worse prognosis in NSCLC patients. Targeting this MDSC subset may help improve the efficacy of NSCLC treatment.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.