Article
Multidisciplinary Sciences
Kenji Kuroda, Takahiro Toyokawa, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Hiroaki Tanaka, Shigeru Lee, Kazuya Muguruma, Masakazu Yashiro, Masaichi Ohira
Summary: This study investigated the correlation between systemic inflammatory response and long-term outcomes in gastric cancer patients and identified potential markers in stage II/III patients. The study found that maximum serum C-reactive protein (CRPmax) was an independent prognostic factor for overall survival and relapse-free survival, while maximum white blood cell count (WBCmax) and infectious complications were not. These findings suggest that CRPmax could be a promising prognostic indicator for stage II/III gastric cancer patients undergoing curative resection.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Sung Gon Kim, Bang Wool Eom, Hongman Yoon, Young-Woo Kim, Keun Won Ryu
Summary: This study evaluated the association between preoperative systemic inflammatory parameters and overall survival in patients with advanced gastric cancer. The results showed that the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were independent prognostic factors for overall survival in patients with advanced gastric cancer. Additionally, an elevated lymphocyte count was the only factor associated with a favorable prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hasan Yilmaz, Naci B. Cinar, Ibrahim E. Avci, Engin Telli, Ali K. Uslubas, Kerem Teke, Ozdal Dillioglugil
Summary: This study aimed to evaluate the prognostic value of the preoperative systemic inflammation response index (SIRI) in predicting outcomes after open radical cystectomy (RC). The results showed that patients with preoperative SIRI >1.91 had significantly higher recurrence rates and lower overall survival rates. SIRI was found to be an independent predictive factor for recurrence-free survival and overall survival, with a higher contribution compared to other inflammatory markers.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Jun-Yan Liu, Jing Yao, Jia-Jia Liu, Tao He, Fang-Jie Wang, Tian-Yu Xie, Jian-Xin Cui, Xiao-Dong Yang
Summary: In this study, a novel survival-related ferroptosis-related lncRNA (FRlncRNA), LASTR, was identified in gastric cancer (GC). High expression of LASTR was associated with shorter overall survival and progression-free survival of GC patients. Knocking down LASTR had a significant effect on reducing the proliferation of GC cells. Additionally, the expression of LASTR was negatively associated with certain immune cells. These findings suggest that LASTR may serve as a novel prognostic biomarker for predicting response to cancer immunotherapy and therapeutic target for GC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yubin Ma, Junpeng Lin, Jianxian Lin, Junfang Hou, Qin Xiao, Fang Yu, Zhijun Ma, Ping Li, Ruhong Tu, Jianwei Xie, Chaohui Zheng, Su Yan, Changming Huang
Summary: The study established a CNLR prognostic scoring system by combining CEA and NLR, finding that CNLR is an independent prognostic factor for GC patients and can improve the accuracy of predicting long-term survival outcomes.
Article
Oncology
Xinyue Qin, Yinhao Chen, Shuo Ma, Lei Shen, Shaoqing Ju
Summary: TM4SF18 is a promising biomarker for gastric cancer, promoting proliferation, migration, and invasion abilities of GC cells, and being associated with immune response.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Chia-Lang Fang, Yu-Feng Tian, Shiau-Shiuan Lin, Shih-Ting Hung, You-Cheng Hseu, Chun-Chao Chang, Chia-Lin Chou, Li-Chin Chen, Wen-Ching Wang, Kai-Yuan Lin, Ding-Ping Sun
Summary: Gastric cancer is the 4th most common and 3rd deadliest cancer worldwide. This study investigated the relationship between GRK3 and gastric cancer prognosis and explored the role of GRK3 in gastric cancer development. The researchers found that GRK3 overexpression was significantly associated with metastasis, TNM stage, and vascular invasion. High GRK3 expression was also linked to shorter disease-free survival and overall survival in patients. Knocking down GRK3 in gastric cancer cells inhibited cell proliferation, migration, and invasion. The findings suggest that GRK3 could potentially serve as a biomarker for gastric cancer prognosis and a target for therapy.
Article
Medicine, Research & Experimental
Jialiang Zheng, Fenglin Miao, Zhao Wang, Yuan Ma, Zhenhang Lin, Yaqin Chen, Xu Kong, Yue Wang, Aobo Zhuang, Ting Wu, Wengang Li
Summary: This study conducted a comprehensive analysis of the role of MDM2 in human cancer and found that MDM2 is a reliable prognostic biomarker closely related to cancer immunity, providing a potential immunotherapeutic target for breast cancer, bladder cancer, and ovarian cancer.
Article
Oncology
Jian-Xian Lin, Ying-Qi Huang, Zu-Kai Wang, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chang-Ming Huang, Chao-Hui Zheng
Summary: The study revealed that preoperative systemic inflammation score is associated with the prognosis of gastric cancer patients; remeasuring SIS at 12 months postoperatively can more accurately predict 5-year overall survival; categorizing patients into different risk groups helps in predicting patient prognosis.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Jing Yang, Hui Wei, Mengxiao Liu, Taobi Huang, Xidong Fang, Xiangqing Ren, Hao Yuan, Ya Zheng, Yuping Wang, Yongning Zhou
Summary: This study found that high expression of HAMP is associated with poor prognosis in gastric cancer, and HAMP affects the survival rate of patients with gastric cancer through immune cell infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Hailun Xie, Guotian Ruan, Lishuang Wei, Li Deng, Qi Zhang, Yizhong Ge, Mengmeng Song, Xi Zhang, Shiqi Lin, Xiaoyue Liu, Ming Yang, Chunhua Song, Xiaowei Zhang, Hanping Shi
Summary: This study compared the performance of existing haematological systemic inflammation biomarkers in predicting the prognosis of NSCLC patients and found that the inflammatory burden index (IBI) is the optimal systemic inflammation biomarker for predicting the prognosis of NSCLC patients. The IBI is associated with overall survival, 90-day outcomes, length of hospitalization, hospitalization expenses, and cachexia in NSCLC patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Jianli Wang, Yanyan Hu, Zhongshu Kuang, Yao Chen, Lingyu Xing, Wei Wei, Mingming Xue, Sucheng Mu, Chaoyang Tong, Yilin Yang, Zhenju Song
Summary: This study evaluates the potential value of GPR174 as a prognostic biomarker for sepsis and explores its pathological function in septic mice. The results suggest that the expressions of GPR174 mRNA are associated with the severity of sepsis and play an important role in the development of sepsis by regulating the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shuo Ma, Shan Kong, Xinliang Gu, Yanhua Xu, Mei Tao, Lei Shen, Xianjuan Shen, Shaoqing Ju
Summary: CircPTPN22 is upregulated in gastric cancer tissues, cells, and plasma, and positively correlated with metastasis. It can serve as a diagnostic marker and predict patient prognosis. CircPTPN22 inhibits cell proliferation and metastasis through competitive binding of miRNAs to regulate the EMT pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Surgery
Recep Caglar
Summary: This study aimed to determine the prognostic values of preoperative inflammatory biomarkers in patients undergoing curative surgery for gastric carcinoma and contribute to the development of prognostic modeling. The medical data of 91 patients who underwent gastrectomy for gastric carcinoma were retrospectively analyzed. The results showed that preoperative inflammatory markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lactate dehydrogenase albumin ratio (LAR), and advanced tumor stage had adverse effects on the survival of gastric carcinoma patients. Further studies with larger sample sizes are needed to validate these findings.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Tianyi Fang, Xin Yin, Yufei Wang, Lei Zhang, Yimin Wang, Xinghai Zhang, Xudong Zhao, Xuan Lin, Yingwei Xue
Summary: This study compared the value of serum inflammatory factors with traditional tumor markers in the prognosis of gastric cancer, and constructed a Nomogram model. It was found that circulating total T cells, CD8+T cells, CEA and CA125 were significantly associated with the prognosis of advanced gastric cancer, and a Nomogram model was constructed using these factors.