Article
Biochemistry & Molecular Biology
Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu
Summary: In this study, the neuroprotective effects of mangiferin against Parkinson's disease (PD) were investigated using cell and mouse models. Mangiferin exhibited therapeutic effects by improving motor behavior, reducing inflammation and oxidative stress. The mechanism behind its neuroprotection was found to involve the regulation of the GIT1 and Keap1/Nrf2 pathways.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Review
Cell Biology
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A. Rockman
Summary: This review explores the signaling pathways, dynamic structures, and physiological relevance of the three most important GPCR signaling effectors in the cardiovascular system: heterotrimeric G proteins, GPCR kinases (GRKs), and 8-arrestins. It summarizes their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. The application of new technologies has contributed to an increasing understanding of GPCR structure and downstream effectors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rikako Sanuki, Tomonori Yamamura
Summary: MiR-124 is strongly expressed in neurons and its reduced expression in cancer cells, especially high malignancy ones, is attributed to DNA methylation and absorption by non-coding RNAs in the promoter region. Studies have shown its tumor-suppressive effects in glial cell lineage cancers and top five deadliest cancers. MiR-124 inhibits proliferation, accelerates apoptosis, and suppresses tumor malignant transformation by regulating target genes like STAT3 and EZH2. Interestingly, there are similarities between genes involved in neuronal maturation and cancer cell metastasis, suggesting potential cross-disciplinary discoveries through the study of MiR-124.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bayram Bayramov, Nuru Bayramov, Hazi Aslanov, Nigar Karimova, Karim Gasimov, Ilham Shahmuradov, Christoph Reissfelder, Vugar Yagublu
Summary: The study investigated the relationship between miR-149 and miR-196a2 small non-coding RNA polymorphisms and the risk of developing colorectal cancer in the Azerbaijani population. The findings suggest that the miR-149 gene mutation may have a protective role in female colorectal cancer, while the miR-196a2 gene polymorphism is associated with an increased risk of colorectal cancer in women.
Article
Biochemistry & Molecular Biology
Ombline Conrad, Mickael Burgy, Sophie Foppolo, Aude Jehl, Alicia Thiery, Sebastien Guihard, Romain Vauchelles, Alain C. C. Jung, Jana Mourtada, Christine Macabre, Sonia Ledrappier, Marie-Pierre Chenard, Mihaela-Alina Onea, Aurelien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Summary: The expression levels of the 3p passenger strands of miR-30a and miR-30e are correlated with the behavior and prognosis of head and neck squamous cell carcinoma. Low expression of miR-30a and miR-30e is associated with adverse prognosis and can potentially be used as biomarkers for diagnosis and treatment of head and neck squamous cell carcinoma. Additionally, miR-30a and miR-30e expression can affect tumor cell behavior and the tumor microenvironment, potentially improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Amani Dhiflaoui, Sana Mahjoub, Vera Chayeb, Bechir Achour, Saoussen Chouchen, Hassen Ben Abdennebi, Touhami Mahjoub, Wassim Y. Almawi
Summary: This study investigated the association of four miR-SNPs (miR-146a, miR-196a2, miR-499, and miR-149) with the risk of acute lymphoblastic leukemia (ALL) in a Tunisian population. The results suggested that the polymorphisms of miR-146a and miR-149 could serve as biomarkers for personalized diagnosis of ALL.
Article
Cell Biology
Peng Zhao, Jianhua Cheng, Bin Li, Ding Nie, Chuzhong Li, Songbai Gui, Hongyun Wang, Yazhuo Zhang
Summary: This study demonstrated that miR-149 and miR-99a-3p induced by exosomes could suppress the progression of IPA. The miRNAs were significantly inhibited in pituitary adenoma cells and tissues, and played inhibitory roles in cell proliferation, metastasis, and angiogenesis.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Genetics & Heredity
Amani Dhiflaoui, Sana Mahjoub, Vera Chayeb, Bechir Achour, Saoussen Chouchen, Hassen Ben Abdennebi, Touhami Mahjoub, Wassim Y. Almawi
Summary: This study investigated the association of four miR-SNPs with altered risk of ALL in Tunisian population, revealing that miR-146a and miR-149 polymorphisms can serve as potential biomarkers for personalized diagnosis of ALL.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Cell Biology
Christian Barbato, Paola Frisone, Laura Braccini, Simona D'Aguanno, Luisa Pieroni, Maria Teresa Ciotti, Caterina Catalanotto, Carlo Cogoni, Francesca Ruberti
Summary: RNA-binding proteins play important roles in miRNA-mediated gene silencing. This study discovered that SERBP1 is a partner protein of Argonaute2, and it participates in miR-92-mediated gene silencing by regulating the 3' UTR of KCC2. These findings advance our understanding of KCC2 translational regulation in neuronal cells and highlight the key role of SERBP1 in this gene regulation.
Article
Biotechnology & Applied Microbiology
Lanyan Fu, Yufen Xu, Hongyan Yu, Lei Pi, Jinqing Li, Huazhong Zhou, Li Zhang, Tingfang Zhang, Di Che, Xiaoqiong Gu
Summary: This study found that the miR-149 rs2292832 T>C polymorphism increased the risk of coronary artery aneurysm (CAA) in Kawasaki disease (KD) patients, while the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients.
JOURNAL OF GENE MEDICINE
(2022)
Review
Immunology
Nan Li, Shan Shan, Xiu-Qin Li, Ting-Ting Chen, Meng Qi, Sheng-Nan Zhang, Zi-Ying Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun
Summary: G protein-coupled receptor kinase 2 (GRK2) plays important roles in regulating signaling pathways associated with fibrotic diseases. Recent research suggests that GRK2 could be a potential therapeutic target for fibrotic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yun-Yao Deng, Yu-Juan Min, Kun Zhou, Qing-Song Yang, Mei Peng, Zhao-Rui Cui, Xiang-Lian Zhu, Hao Liu, Min Wang, Xie Zhang, Li-Xin Liu
Summary: This study demonstrated that circ-FOXO3 inhibits CRC metastasis and progression by increasing LATS1 expression via sponging miR-543.