Review
Oncology
Pengbo Wang, Zengkuan Zhu
Summary: Expression of E-cadherin is closely associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting it may serve as an effective biomarker for clinical assessments and predicting prognosis in patients with pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Nora Karsten, Thomas Kolben, Sven Mahner, Susanne Beyer, Sarah Meister, Christina Kuhn, Elisa Schmoeckel, Rachel Wuerstlein, Nadia Harbeck, Nina Ditsch, Udo Jeschke, Klaus Friese, Theresa Maria Kolben
Summary: The study revealed that increased E-Cadherin expression in primary tumor tissue of breast cancer patients is associated with poor prognosis, contrary to previous beliefs that loss of E-Cadherin promotes metastasis and invasiveness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Oncology
Weimin Wang, Jun Jin, Zhen Zhou, Yunfan Wang, Ke Min, Xin Zuo, Jiaping Jiang, Yan Zhou, Jun Shi
Summary: The overall survival rate of colorectal cancer patients is low, and the identification of valuable prognostic markers is urgently needed. This study investigated the clinical significance of Snail and E-cad expression in colorectal cancer and found that low Snail and high E-cad expression are associated with better prognosis.
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng
Summary: Thyroid carcinoma is a common and problematic cancer, with recurrence and metastasis being significant issues. Understanding the role of EMT and E-cadherin in tumors is crucial for cancer therapeutics.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Lukasz Lewczuk, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz
Summary: The study aimed to examine the protein expression levels of E-, N- and P-cadherin in cancer tissue from patients with endometrial cancer and their effects on clinicopathological parameters. Immunohistochemistry revealed uneven distribution of these cadherins in endometrial cancer tissue, with higher expression levels at the tumor front. Additionally, lower membrane expression levels of the 3 cadherin proteins were observed in metastatic cancer cells compared to primary tumor cells.
Review
Medicine, General & Internal
Dong Chao, Gawei Hu, Qingxin Li
Summary: In non-small cell lung cancer, high expression of E-cadherin is associated with better overall survival and disease-free survival, with a positive impact on prognosis. Additionally, low expression is linked to poor differentiation, advanced stage, and lymph node metastasis of lung cancer.
Article
Medicine, Research & Experimental
O. V. Kovaleva, P. A. Podlesnaya, V. V. Mochalnikova, N. E. Kushlinskii, A. N. Gratchev
Summary: We investigated the expression of CD66b in tumor and stromal cells of non-small cell lung cancer samples. The presence of CD66b(+) neutrophils did not correlate with clinical and morphological parameters or prognosis. However, CD66b was expressed in tumor cells of most samples, and its expression correlated with tumor histological type and localization. Increased CD66b expression in tumor cells was associated with a more favorable prognosis, suggesting its potential as a prognostic marker and immunotherapy target.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Jiming Tian, Xiaolei Liang, Dalin Wang, Jinglin Tian, Haiping Liang, Ting Lei, Zeyu Yan, Dan Wu, Xiaoli Liu, Shujuan Liu, Yongxiu Yang
Summary: This study found that TBC1D2 is upregulated in ovarian cancer (OC) and promotes tumor metastasis through E-cadherin degradation. Additionally, miR-373-3p inhibits OC cell invasion by negatively regulating TBC1D2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Su-Chi Ku, Hsin-Liang Liu, Che-Yu Su, I-Jeng Yeh, Meng-Chi Yen, Gangga Anuraga, Hoang Dang Khoa Ta, Chung-Chieh Chiao, Do Thi Minh Xuan, Fidelia Berenice Prayugo, Wei-Jan Wang, Chih-Yang Wang
Summary: The study found that mRNA levels of CDH1/2/4/11/12/13 genes were overexpressed in breast cancer cells compared to normal cells and correlated with poor prognosis in breast cancer patients. The high expressions of these genes were significantly associated with cell adhesion, extracellular matrix remodeling, EMT, WNT/beta-catenin, and interleukin-mediated immune responses, suggesting they could be potential biomarkers for breast cancer progression and metastasis.
Article
Oncology
Jifang Zheng, Hejun Zhang, Siya Li, Zhaoxin Kang, Fei Zheng, Qiwei Yao, Xueqing Zhang, Ziyi Wu, Jiezhong Wang, Weimin Fang, Jiancheng Li, Gang Chen, Yuangui Chen, Mingqiu Chen
Summary: This study aimed to assess the prognostic value of H&E-TILs in ESCC treated with CCRT. The results showed significant differences in short-term response and survival rates between the H&E-TILs (+) and H&E-TILs (-) groups. H&E-TILs may be an effective and beneficial prognostic biomarker for ESCC patients treated with CCRT.
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Oncology
Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin, Weihua Fu
Summary: The study revealed that upregulated expression of CDH6 in gastric cancer is associated with diagnosis and prognosis, making it a potential independent molecular biomarker.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Marta Peksa, Alexandra Kamieniecki, Anna Gabrych, Anna Lew-Tusk, Krzysztof Preis, Malgorzata Swiatkowska-Freund
Summary: Pregnancy-induced hypertension and pre-eclampsia are serious complications of pregnancy, and the abnormality of the placental barrier is believed to be involved in their pathogenesis. This study found a correlation between the discontinuity of E-cadherin expression and the development of pre-eclampsia, suggesting that it could be an immunohistochemical marker.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Maria D. Vazquez-Carretero, Pablo Garcia-Miranda, Maria S. Balda, Karl Matter, Anunciacion A. Ilundain, Maria J. Peral
Summary: The study shows that Dab2 is crucial for maintaining adherens junctions in the intestine, and its absence may contribute to the development of colon inflammation and cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)