mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways

Molecular neurobiology of mTOR

(2017) Katarzyna Switon et al.   NEUROSCIENCE

Haploinsufficiency of the STX1B gene is associated with myoclonic astatic epilepsy

(2016) Danique R.M. Vlaskamp et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications for neurological disease

(2016) Saak V. Ovsepian et al.   PHARMACOLOGY & THERAPEUTICS

SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus

(2016) Suleman Hussain et al.   Frontiers in Molecular Neuroscience

The Synaptic Vesicle Release Machinery

(2015) Josep Rizo et al.   Annual Review of Biophysics

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide

(2015) Francesco Tamagnini et al.   HIPPOCAMPUS

Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD

(2015) Natasha M. Sosanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)

(2015) Farr Niere et al.   MOLECULAR & CELLULAR PROTEOMICS

Rapid antidepressants stimulate the decoupling of GABAB receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η

(2015) E R Workman et al.   MOLECULAR PSYCHIATRY

Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis

(2015) Natasha M. Sosanya et al.   NEUROBIOLOGY OF DISEASE

Altered Neuronal and Circuit Excitability in Fragile X Syndrome

(2015) Anis Contractor et al.   NEURON

Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

(2015) Francesco Tamagnini et al.   Frontiers in Cellular Neuroscience

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes

(2014) Julian Schubert et al.   NATURE GENETICS

Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses

(2014) Tatsuya Mishima et al.   PLoS One

The dendritic SNARE fusion machinery involved in AMPARs insertion during long-term potentiation

(2014) Sandra Jurado   Frontiers in Cellular Neuroscience

mTOR Strikes Again: mTORC1 Activation Causes Epilepsy Independent of Overt Pathological Changes

(2014) Michael Wong   Epilepsy Currents

Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures

(2014) Matthew C. Weston et al.   Frontiers in Molecular Neuroscience

LGI Proteins in the Nervous System

(2013) Linde Kegel et al.   ASN Neuro

Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1

(2013) Natasha M. Sosanya et al.   JOURNAL OF CELL BIOLOGY

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

(2013) T. Ohkawa et al.   JOURNAL OF NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

(2013) Sandra Jurado et al.   NEURON

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Potassium Channels Control the Interaction between Active Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons

(2013) Mark T. Harnett et al.   NEURON

mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling

(2013) E.R. Workman et al.   NEUROPHARMACOLOGY

Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

(2013) Amy L. Brewster et al.   PLoS One

Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy

(2013) Florian Kirchheim et al.   Frontiers in Cellular Neuroscience

Late Steps in Secretory Lysosome Exocytosis in Cytotoxic Lymphocytes

(2013) Peter van der Sluijs et al.   Frontiers in Immunology

Channelopathy pathogenesis in autism spectrum disorders

(2013) Galina Schmunk et al.   Frontiers in Genetics

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Dendritic ion channelopathy in acquired epilepsy

(2012) Nicholas P. Poolos et al.   EPILEPSIA

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Evidence for a Fragile X Mental Retardation Protein-Mediated Translational Switch in Metabotropic Glutamate Receptor-Triggered Arc Translation and Long-Term Depression

(2012) F. Niere et al.   JOURNAL OF NEUROSCIENCE

Synaptic amplification by dendritic spines enhances input cooperativity

(2012) Mark T. Harnett et al.   NATURE

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

(2012) Jennifer A Ronesi et al.   NATURE NEUROSCIENCE

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats

(2012) X. Huang et al.   NEUROSCIENCE

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

(2012) Agata Chandran et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Altered Neocortical Rhythmic Activity States in Fmr1 KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry

(2011) S. A. Hays et al.   JOURNAL OF NEUROSCIENCE

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Bidirectional Regulation of Dendritic Voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein

(2011) Hye Young Lee et al.   NEURON

Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites

(2011) Thomas Kleindienst et al.   NEURON

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

(2011) Hiroshi Makino et al.   NEURON

Diverse roles for auxiliary subunits in phosphorylation-dependent regulation of mammalian brain voltage-gated potassium channels

(2011) Helene Vacher et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Syntaxin 11 Binds Vti1b and Regulates Late Endosome to Lysosome Fusion in Macrophages

(2011) Carolin Offenhäuser et al.   TRAFFIC

Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs

(2011) Emanuela Santini et al.   Frontiers in Behavioral Neuroscience

Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice

(2010) Elodie Chabrol et al.   BRAIN

Syntaxin-4 Defines a Domain for Activity-Dependent Exocytosis in Dendritic Spines

(2010) Matthew J. Kennedy et al.   CELL

Plasticity of voltage-gated ion channels in pyramidal cell dendrites

(2010) S Remy et al.   CURRENT OPINION IN NEUROBIOLOGY

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

(2010) Y. Eugene Yu et al.   HUMAN MOLECULAR GENETICS

The decade of the dendritic NMDA spike

(2010) Srdjan D. Antic et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Functional interplay between NMDA receptors, SK channels and voltage-gated Ca2+channels regulates synaptic excitability in the medial prefrontal cortex

(2010) E. S. L. Faber   JOURNAL OF PHYSIOLOGY-LONDON

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intrinsic Plasticity in Acquired Epilepsy: Too Much of a Good Thing?

(2010) John D. Graef et al.   NEUROSCIENTIST

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

(2010) Yuko Fukata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic ion channel trafficking and plasticity

(2010) Mala M. Shah et al.   TRENDS IN NEUROSCIENCES

Arrested Glutamatergic Synapse Development in Human Partial Epilepsy

(2010) Matthew P. Anderson   Epilepsy Currents

Pathophysiology of Locus Ceruleus Neurons in a Mouse Model of Rett Syndrome

(2009) P. Taneja et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons

(2009) Judit K Makara et al.   NATURE NEUROSCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Forskolin induction of late-LTP and up-regulation of 5 TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

(2008) Delphine Gobert et al.   JOURNAL OF NEUROCHEMISTRY

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice

(2008) M. D. Antion et al.   MOLECULAR AND CELLULAR BIOLOGY

Compartmentalized dendritic plasticity and input feature storage in neurons

(2008) Attila Losonczy et al.   NATURE

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

(2008) Sungjin Park et al.   NEURON

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

(2008) Maggie W. Waung et al.   NEURON

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS