Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2017.00374
Keywords
synapses; astroglia; tripartite synapse; super-resolution microscopy; plasticity
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Funding
- Wellcome Trust [101896]
- European Research Council [AdG 323 113-NETSIGNAL, PoC 767372-NEUROCLOUD]
- European Commission [ITN 606950 EXTRABRAIN]
- Russian Science Foundation (EM reconstructions) [15-14-30000]
- Medical Research Council [G0900613, G0600368, G0802216] Funding Source: researchfish
- Russian Science Foundation [15-14-30000] Funding Source: Russian Science Foundation
- MRC [G0802216, G0900613, G0600368] Funding Source: UKRI
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Synaptic connections between individual nerve cells are fundamental to the process of information transfer and storage in the brain. Over the past decades a third key partner of the synaptic machinery has been unveiled: ultrathin processes of electrically passive astroglia which often surround pre-and postsynaptic structures. The recent advent of super-resolution (SR) microscopy has begun to uncover the dynamic nanoworld of synapses and their astroglial environment. Here we overview and discuss the current progress in our understanding of the synaptic nanoenvironment, as gleaned from the imaging methods that go beyond the diffraction limit of conventional light microscopy. We argue that such methods are essential to achieve a new level of comprehension pertinent to the principles of signal integration in the brain.
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