Journal
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/6490473
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Funding
- Swedish Research Council
- Novo Nordisk Foundation
- Skane Regional Council, ALF
- Albert Pahlsson Foundation
- Swedish Heart and Lung Foundation
- Medical Faculty of Lund University
- Skane University Hospital
- Ernhold Lundstroms Research Foundation
- Hulda and Conrad Mossfelt Foundation
- Southwest Skane Diabetes Foundation
- King Gustaf V and Queen Victoria Foundation
- Lennart Hanssons Memorial Fund
- Knut and Alice Wallenberg Foundation
- Marianne and Marcus Wallenberg Foundation
- Crafoord Foundation
- Novo Nordisk Fonden [NNF13OC0005339, NNF14OC0009819] Funding Source: researchfish
- Steno Diabetes Center Copenhagen (SDCC) [SDCC 3.A Complications] Funding Source: researchfish
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Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malm Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the = 10% weight loss group with an associated change in BMI (R-2 = 0 16-0 22, p < 0 002), whereas the scores increased in the < 10% weight loss group (p < 0 0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.
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