Journal
INTERNATIONAL BRAZ J UROL
Volume 43, Issue 5, Pages 841-848Publisher
BRAZILIAN SOC UROL
DOI: 10.1590/S1677-5538.IBJU.2017.0095
Keywords
Adrenocortical Carcinoma; Radiotherapy, Adjuvant; Therapeutics
Categories
Ask authors/readers for more resources
Purpose: To evaluate the role of ARDT after surgical resection of ACC. Materials and Methods: Records of patients from our institutional ACC database were retrospectively assessed. A paired comparison analysis was used to evaluate the oncological outcomes between patients treated with surgery followed by ARDT or surgery only (control). The endpoints were LRFS, RFS, and OS. A systematic review of the literature and metaanalysis was also performed to evaluate local recurrence of ACC when ARDT was used. Results: Ten patients were included in each Group. The median follow-up times were 32 months and 35 months for the ARDT and control Groups, respectively. The results for LRFS (p= 0.11), RFS (p= 0.92), and OS (p= 0.47) were similar among subsets. The mean time to present with local recurrence was significantly longer in the ARDT group compared with the control Group (419 +/- 206 days vs. 181 +/- 86 days, respectively; p= 0.03). ARDT was well tolerated by the patients; there were no reports of late toxicity. The meta-analysis, which included four retrospective series, revealed that ARDT had a protective effect on LRFS (HR= 0.4; CI= 0.17-0.94). Conclusions: ARDT may reduce the chance and prolong the time to ACC local recurrence. However, there were no benefits for disease recurrence control or overall survival for patients who underwent this complementary therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available