Article
Oncology
Margaret I. Liang, Ling Chen, Dawn L. Hershman, Grace C. Hillyer, Warner K. Huh, Allison Guyton, Jason D. Wright
Summary: This study evaluated the total and out-of-pocket costs for PARP inhibitors among ovarian cancer patients with different insurance characteristics. The findings revealed that commercially insured patients had lower out-of-pocket costs compared to SEER-Medicare beneficiaries. Additionally, patients with supplemental Medicaid prescription coverage were able to offset the increased out-of-pocket costs.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Moges Tadesse Borde, Robel Hussen Kabthymer, Mohammed Feyisso Shaka, Semagn Mekonnen Abate
Summary: Household Out-Of-Pocket healthcare expenditure in Ethiopia is high, especially for economically disadvantaged households. This study reveals the inequity and injustice in financial burden and emphasizes the need for national healthcare policies to focus on poor households.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2022)
Article
Dermatology
Emmanuelle Bourrat, Charles Taieb, Adrien Marquie, Patricia Causse, Christina Bergqvist, Angelique Sauvestre, Nathalia Bellon
Summary: This study aimed to evaluate the burden of disease and out-of-pocket expenditures for families with a child affected by Epidermolysis Bullosa (EB) in France. The findings revealed that EB places a considerable burden on families' daily lives, with out-of-pocket expenses being 20 times higher compared to the French population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Environmental Sciences
Mohamed Fakhri Abu Baharin, Muhamad Hanafiah Juni, Rosliza Abdul Manaf
Summary: This study assessed the distribution and progressivity of out-of-pocket (OOP) payments for various healthcare services by Malaysian households. The results showed that OOP payments in Malaysia were more concentrated among richer households, indicating progressivity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Otorhinolaryngology
Sean T. Massa, Smrithi Chidambaram, Peter Luong, Evan M. Graboyes, Angela L. Mazul
Summary: This retrospective study analyzed the costs of head and neck cancer (HNC) survivors in the US from 2006 to 2018. The study found that the costs of HNC survivorship remain persistently elevated above baseline costs for at least 5 years after diagnosis, with high costs associated with female sex, hypopharyngeal tumors, and treatment with multimodal therapy.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Endocrinology & Metabolism
Huan Yu, Chaoyang Zhang, Yan Cai, Ning Wu, Xiuqin Jia, Jiaojiao Wu, Feng Shi, Rui Hua, Qi Yang
Summary: This study investigated the morphological brain-tissue changes in patients with dialysis- and non-dialysis-dependent chronic kidney disease (CKD), and analyzed the effects of CKD on brain cortical thickness, volume, surface area, and curvature. The results showed that CKD patients exhibited significant and widespread decrease in cortical thickness and volume compared to normal controls. The extent of brain atrophy was further increased in dialysis-dependent CKD patients. The findings suggest that blood urea nitrogen and dialysis may play a role in brain morphological changes in CKD patients.
METABOLIC BRAIN DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Guvenc Kockaya, Gulpembe Oguzhan, Selin Okcun, Mustafa Kurnaz
Summary: This study aimed to determine the out-of-pocket health expenditures of households in Turkey where individuals with rare diseases are residing. A total of 439 participants were included in the analysis. Special nutrition was found to be the highest expenditure group and emergency departments were the lowest expenditure group.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Urology & Nephrology
Dhananjai Agrawal, Deepak Varade, Hardik Shah, Alm Nazar, Jayakumar Krishnan, Vineet Shukla, Chinta Ramakrishna, Mahel Chinthana Bandara Galahitiyawa, Sidhharth B. Mavani, Sunil Rajanna, Petkar Jikki, Shamila De Silva, Vivek Ruhela, Parshottam Koradia, Kevinkumar Kansagra, Pooja Kanani, Nitin Sharma, Kuldipsinh Zala, Deven Parmar
Summary: Desidustat is non-inferior to darbepoetin in the treatment of anemia due to non-dialysis dependent CKD and it is well-tolerated.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Letter
Medicine, General & Internal
H. Franklin Bunn
Summary: The trials show convincing evidence that vadadustat is effective in treating anemia in patients with chronic kidney disease, compared to darbepoetin alfa which has prolonged life span in circulation.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Transplantation
Ahmed A. Awan, Carl P. Walther, Peter A. Richardson, Maulin Shah, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Summary: In patients with chronic kidney disease and anemia, absolute and functional iron deficiency anemia were associated with various clinical covariates. Functional IDA was linked to an increased risk of mortality and cardiovascular hospitalization, while absolute IDA was only associated with a higher risk of hospitalization.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Multidisciplinary Sciences
Abdur Razzaque Sarker, S. M. Zulfiqar Ali, Maruf Ahmed, S. M. Zahedul Islam Chowdhury, Nausad Ali
Summary: This study investigates the self-reported illnesses and out-of-pocket healthcare expenditures among urban citizens in Dhaka, Bangladesh, and identifies the influence of socioeconomic, demographic, and behavioral factors on the expenditures.
Article
Genetics & Heredity
Mehmet Gunduz, Yasemin Yuksel Gudek, cigdem Seher Kasapkara
Summary: The aim of this study was to determine the out-of-pocket health expenditures of patients with inborn errors of metabolism during follow-up and treatment processes, and to determine the economic burden on families. The results showed that the average out-of-pocket expenditure of households in the last month was 1039.22 Turkish Liras, and 9.9% of parents made catastrophic health expenditures. Patients with amino acid metabolism disorders had a higher rate of catastrophic expenditure compared to patients with vitamin and cofactor metabolism disorders. It is necessary to conduct more comprehensive studies to determine and prevent the socioeconomic effects of out-of-pocket health expenditures for patients with inborn errors of metabolism.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Pharmacology & Pharmacy
Akitsugu Takada, Tomohisa Shibata, Takanori Shiga, Dorien Groenendaal-van de Meent, Kanji Komatsu
Summary: The study developed a population PK model to describe roxadustat plasma concentrations in Japanese DD-CKD patients and identified age and phosphate binders as key factors affecting roxadustat clearance and bioavailability.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Shafi Malik, Amir Bhanji, Husham Abuleiss, Rizwan Hamer, Shahzad H. Shah, Rafaqat Rashad, Naushad Junglee, Salman Waqar, Nazim Ghouri
Summary: Fasting during Ramadan poses challenges for patients with CKD, who may experience electrolyte imbalances and worsening renal function. A comprehensive risk assessment and medical advice are recommended for CKD patients wishing to fast, ideally one month before Ramadan, to fast safely. Patients are categorized into risk tiers, with alternative fasting options encouraged for those at very high or high risk, while low-moderate risk patients may fast safely with clinician guidance.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Surgery
Charles Liu, Melinda Maggard-Gibbons, Thomas G. Weiser, Arden M. Morris, Yusuke Tsugawa
Summary: The study found that the ACA's insurance Marketplaces were associated with improved financial protection among low-income surgical patients eligible for both cost-sharing and premium subsidies, but not in middle-income patients eligible for only premium subsidies.