Review
Medicine, General & Internal
Andres Vecino-Ortiz, Madhuram Nagarajan, Sarah Elaraby, Deivis Nicolas Guzman-Tordecilla, Nino Paichadze, Adnan A. Hyder
Summary: This paper estimates the potential number of lives that could be saved by implementing interventions to address risk factors for road injuries. The results show that evidence-based road safety interventions targeting the four main risk factors could prevent 25% to 40% of fatal road injuries globally.
Review
Medicine, General & Internal
Adnan A. Hyder, Connie Hoe, Martha Hijar, Margaret Peden
Summary: The goal of this paper is to explore the evolution of road safety as a global public health issue and examine the political and economic factors that have contributed to this change. By discussing key stakeholders, influences, networks, issue framing, actor power, and synergistic interactions, the paper captures the important events and challenges that highlight the complexity of road safety. The authors suggest the need for the global road safety community to reassess its role and strategy and focus on implementation and country action to reduce road traffic injuries. They call for an open and inclusive process to facilitate this reflection before the end of the current decade.
Article
Plant Sciences
Jia Liu, Li-dong Gao, Bin Fu, Hong-tao Yang, Lin Zhang, Shu-qiang Che, Ying Xu, Xi Du, Zhi-chao Liu, Yu Xue, Chun-Xiao Lv, Yu-hong Huang, Bao-He Wang, Shi-Xing Gao, Yong-Fa Xing, Xin-hui Yuan
Summary: This study compared the effects of ZCY and HKC in the treatment of diabetic kidney disease and found that ZCY had better efficacy in improving and protecting kidney function. It was particularly beneficial for patients with declining glomerular filtration rate and gut microbiota dysbiosis.
Article
Clinical Neurology
Edmond Teng, Paul T. Manser, Karen Pickthorn, Flavia Brunstein, Mira Blendstrup, Sandra Sanabria Bohorquez, Kristin R. Wildsmith, Bali Toth, Michael Dolton, Vidya Ramakrishnan, Ashwini Bobbala, Sietske A. M. Sikkes, Michael Ward, Reina N. Fuji, Geoffrey A. Kerchner
Summary: In this study, semorinemab did not slow clinical progression in patients with prodromal to mild AD, but demonstrated good safety. Further research is needed to determine the clinical utility of anti-tau antibody therapy.
Article
Humanities, Multidisciplinary
Jose Ignacio Nazif-Munoz, Arnelie Quesnel-Vallee, Axel van den Berg
Summary: The study finds that global convergence of public policies in the road safety realm varies for different measures, with child restraint laws being the only policy that shows global convergence. In terms of policy adoption mechanisms, imitation/learning and competition explain global and regional convergence outcomes more consistently, highlighting specific elective affinities in policy diffusion.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Guitti Pourdowlat, Fatemeh Saghafi, Abolfazl Mozafari, Adeleh Sahebnasagh, Atefeh Abedini, Mohsen Nabi Meybodi, Ali Salehi Nezamabadi, Seyed Ruhollah Mousavinasab, Arda Kiani, Hanieh Raji, Nadia Soltani, Mehdi Gholmzadeh Baeis, Esmaeil Eidani, Abdolrahim Sadeghi Yakhdani, Fatemeh Movaseghi, Solomon Habtemariam, Zohreh Akhoundi Meybodi, Mohsen Gholinataj Jelodar
Summary: Colchicine has shown clinical benefits in the management of COVID-19 through its anti-inflammatory effect. It can improve clinical outcomes and reduce pulmonary infiltration in COVID-19 patients.
PHYTOTHERAPY RESEARCH
(2022)
Article
Medicine, General & Internal
Zhengbo Song, Yuping Li, Shiqing Chen, Shenpeng Ying, Shuguang Xu, Jianjin Huang, Dan Wu, Dongqing Lv, Ting Bei, Shuxun Liu, Xiaoping Huang, Congying Xie, Xiaoyu Wu, Jianfei Fu, Feng Hua, Wenxian Wang, Chunwei Xu, Chan Gao, Shangli Cai, Shun Lu, Yiping Zhang
Summary: The study explored the efficacy and safety of pyrotinib in NSCLC patients with HER2 mutations, finding promising efficacy and acceptable safety, warranting further investigation.
Article
Gastroenterology & Hepatology
Toshio Uraoka, Noriya Uedo, Tsuneo Oyama, Yutaka Saito, Naohisa Yahagi, Ai Fujimoto, Yoshiro Kawahara, Katsuhiro Mabe, Takuto Hikichi, Yorimasa Yamamoto, Hisao Tajiri
Summary: This study compared the effectiveness of the novel hemostatic peptide TDM-621 with conventional hemostatic methods for treating intraoperative blood oozing during endoscopic submucosal dissection (ESD). The results showed that the TDM-621 group had significantly reduced coagulations with hemostatic forceps, a higher rate of hemostasis achievement with only TDM-621, and no serious safety concerns.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Urology & Nephrology
Yanqi Yin, Yaxue Shi, Tianlei Cui, Hua Li, Jianghua Chen, Lihong Zhang, Zhengya Yu, Hong Li, Yan Yan, Kun Wu, Qizhuang Jin
Summary: This study demonstrated that in Chinese hemodialysis patients, using DCB for treating AVF restenosis achieved superior primary patency at 6 months and intervention-free survival at 12 months for both the target lesion and target shunt compared to conventional HPB angioplasty.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Integrative & Complementary Medicine
Jie Wu, Shu-wei Duan, Hong-tao Yang, Yue-yi Deng, Wei Li, Ya-ni He, Zhao-hui Ni, Yong-li Zhan, Shan Lin, Zhi-yong Guo, Jun Zhu, Jing-ai Fang, Xu-sheng Liu, Li-hua Wang, Rong Wang, Nian -song Wang, Xiao-hong Cheng, Li-qun He, Ping Luo, Shi-ren Sun, Ji-feng Sun, Ai-ping Yin, Geng-ru Jiang, Hong-yu Chen, Wen-hu Liu, Hong-li Lin, Meng Liang, Lu Ma, Ming Chen, Li-qun Song, Jian Chen, Qing Zhu, Chang-ying Xing, Yun Li, Ji-ning Gao, Rong-sha Li, Ying Li, Hao Zhang, Ying Lu, Qiao-ling Zhou, Jun-zhou Fu, Qiang He, Guang-yan Cai, Xiang-mei Chen
Summary: The study demonstrated that SYKFT significantly reduced proteinuria and improved traditional Chinese medicine (TCM) syndrome scores in primary glomerulonephritis patients; SYKFT combined with losartan potassium therapy was more effective in reducing proteinuria compared to losartan potassium therapy alone; There were no significant differences observed in eGFR, serum creatinine, and serum albumin levels between groups.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Immunology
Kevin W. Garey, Jacob McPherson, An Q. Dinh, Chenlin Hu, Jinhee Jo, Weiqun Wang, Chris K. Lancaster, Anne J. Gonzales-Luna, Caroline Loveall, Khurshida Begum, M. Jahangir Alam, Michael H. Silverman, Blake Hanson
Summary: This study validates the effectiveness of ibezapolstat in treating adult patients with Clostridioides difficileinfection. The results show sustained clinical cure and beneficial effects on the microbiome and bile acids.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Sophie Dupuis-Girod, Sophie Riviere, Christian Lavigne, Anne-Emmanuelle Fargeton, Brigitte Gilbert-Dussardier, Vincent Grobost, Vanessa Leguy-Seguin, Helene Maillard, Shirine Mohamed, Evelyne Decullier, Adeline Roux, Lorraine Bernard, Jean-Christophe Saurin, Nicolas Saroul, Frederic Faure, Cesar Cartier, Romain Altwegg, Laurent Laccourreye, Frederic Oberti, Marjolaine Beaudoin, Carole Dhelens, Celine Desvignes, Nicolas Azzopardi, Gilles Paintaud, Ruben Hermann, Thierry Chinet
Summary: This study is a double-blind multicenter randomized phase 2 trial investigating the efficacy of bevacizumab in patients with hereditary hemorrhagic telangiectasia (HHT). The results showed that patients receiving bevacizumab required fewer red blood cell transfusions, particularly those with high exposure.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Critical Care Medicine
Yongjun Liu, Zhiyong Peng, Songqiao Liu, Xiangyou Yu, Duming Zhu, Linlin Zhang, Jianli Wen, Youzhong An, Liying Zhan, Xiaochuang Wang, Yan Kang, Aijun Pan, Jing Yan, Lina Zhang, Fengming Liu, Jun Zeng, Qinhan Lin, Renhua Sun, Jiangquan Yu, Huaxue Wang, Li Yao, Chuanxi Chen, Ning Liu, Yao Nie, Jie Lyu, Kun Wu, Jianfeng Wu, Xiao Liu, Xiangdong Guan
Summary: The study found that Ciprofol has a comparable sedation profile to propofol in Chinese ICU patients undergoing mechanical ventilation, and it is well tolerated.
CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ai Wei, Shijin Ma, Yuzhe Dou, Xiaojun Wang, Jianxiong Wu, Shuzhi Zhou, Yanfang Deng, Xinquan Liu, Dongming Li, Mengchang Yang
Summary: This study aimed to explore the advantages of the combination of remimazolam tosylate and propofol. The results showed that co-administration had a lower incidence of hypotension compared to propofol monotherapy, as well as a better sedative effect and higher endoscopist satisfaction compared to remimazolam monotherapy.
Article
Microbiology
Taiga Miyazaki, Naoki Hosogaya, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Yoshihito Ozawa, Yuki Shiko, Yosuke Inaba, Tomoya Kurokawa, Hideki Hanaoka, Shoya Iwanami, Kwangsu Kim, Shingo Iwami, Koichi Watashi, Ken Miyazawa, Takashi Umeyama, Satoshi Yamagoe, Yoshitsugu Miyazaki, Takaji Wakita, Makoto Sumiyoshi, Tatsuro Hirayama, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae, Hitoshi Kawasuji, Yoshihiro Yamamoto, Norihito Tarumoto, Hiroshi Ishii, Hideaki Ohno, Kazuhiro Yatera, Hiroshi Kakeya, Yoshiko Kichikawa, Yasuyuki Kato, Tetsuya Matsumoto, Makoto Saito, Hiroshi Yotsuyanagi, Shigeru Kohno
Summary: The anti-HIV drug nelfinavir inhibits the replication of SARS-CoV-2 in vitro, but its efficacy in COVID-19 patients has not been studied. A randomized controlled trial was conducted to evaluate the clinical efficacy and safety of nelfinavir in SARS-CoV-2 infected patients. The results showed that nelfinavir did not reduce the time to viral clearance, viral load, or the time to resolution of symptoms compared to standard-of-care alone. Therefore, nelfinavir is not recommended for asymptomatic or mildly symptomatic COVID-19 patients.
MICROBIOLOGY SPECTRUM
(2023)
