Journal
JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 6, Pages 341-345Publisher
SCIENCE REVIEWS 2000 LTD
DOI: 10.3184/174751917X14949427622099
Keywords
N-propargylation; secondary amine; calcium carbide; acetylene source; propargylic tertiary amine
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Funding
- National Natural Science Foundation of China [21462038, 21362034]
- Key Laboratory of Eco-Environment-Related Polymer Materials for Ministry of Education
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A one-pot N-propargylation of secondary amines has been achieved by heating the amine with formaldehyde and calcium carbide in DMSO in the presence of CuCl as a catalyst. Fifteen examples of propargylic tertiary amines, 12 of which are novel, were efficiently prepared in yields of 65-84%. The advantages of the method are broad substrate scope and a simple work-up procedure.
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