Journal
CHEMICAL SCIENCE
Volume 8, Issue 2, Pages 1015-1020Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc02587k
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Funding
- NIGMS [TR-GM80442]
- Royal Thai Government
- EPSRC UK National Service for Computational Chemistry Software [CHEM773]
- SCG
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The diastereoselective coupling of O-substituted arylhydroxamates and cyclopropenes mediated by Rh(III) catalysis was successfully developed. Through ligand development, the diastereoselectivity of this reaction was improved using a heptamethylindenyl (Ind*) ligand, which has been rationalized using quantum chemical calculations. In addition, the nature of the O-substituted ester of benzhydroxamic acid proved important for high diastereoselectivity. This transformation tolerates a variety of benzamides and cyclopropenes that furnish cyclopropa[c] dihydroisoquinolones with high diastereocontrol, which could then be easily transformed into synthetically useful building blocks for pharmaceuticals and bio-active molecules.
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