Article
Oncology
Alexander Katalinic, Marco Halber, Martin Meyer, Maren Pflueger, Andrea Eberle, Alice Nennecke, Soo-Zin Kim-Wanner, Tobias Hartz, Kerstin Weitmann, Andreas Stang, Christina Justenhoven, Bernd Holleczek, Daniela Piontek, Ian Wittenberg, Annika Hessmer, Klaus Kraywinkel, Claudia Spix, Ron Pritzkuleit
Summary: Cancer registration in Germany has a long tradition and in 2013, new legislation mandated the implementation of additional clinical cancer registration. The aim was to measure and improve the quality of cancer care. The current status of extended cancer registration in Germany shows a slight decrease in the age-standardized incidence of cancer over the last decade. The five-year relative survival rate for all cancers is 67% for women and 63% for men.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lando S. Bosma, Cornel Zachiu, Baudouin Denis de Senneville, Bas W. Raaymakers, Mario Ries
Summary: The purpose of this study is to investigate the ability of existing intensity-based quality assurance criteria, structural similarity and normalized mutual information, to quickly and reliably identify registration errors in radiotherapy. These criteria were tested using synthetic and simulated biomechanical deformations of 3D MR images as well as manually annotated 4D CT data. The results showed that the intensity-based criteria provide the required confidence in using mono-modal registrations in clinical workflows and enable automated quality assurance for deformable image registration in adaptive radiotherapy treatments.
Article
Gastroenterology & Hepatology
Yazmin San Miguel, Joshua Demb, Maria Elena Martinez, Samir Gupta, Folasade P. May
Summary: The study found that delayed colonoscopy completion after an abnormal stool-based colorectal cancer screening test is associated with higher risk of CRC incidence, death, and late-stage CRC. Therefore, interventions to improve CRC outcomes should emphasize diagnostic follow-up within 1 year of abnormal screening results.
Article
Oncology
Sabrina Wang, Farhana Sultana, Anne Kavanagh, Carolyn Nickson, Amalia Karahalios, Lyle C. Gurrin, Dallas R. English
Summary: This study aimed to quantify the impact of mammographic screening on breast cancer mortality and overdiagnosis. The results showed that women who participate in Australia's national screening program have lower breast cancer mortality, but some screen-detected cancers may be overdiagnosed.
Article
Oncology
Andreas Stang, Katrin Schuldt, Pietro Trocchi, Silke Neusser, Christian Speckemeier, Kathrin Pahmeier, Juergen Wasem, Hildegard Lax, Michael Nonnemacher
Summary: This paper aimed to evaluate the mortality of skin cancer screening in Germany using data from the General Local Health Insurance Fund (AOK). It found that the cumulative SCS prevalence increased among controls over time, while among cases, the SCS prevalence did not show a significant increase in the years of diagnosis.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohamed A. A. Naser, Kareem A. A. Wahid, Sara Ahmed, Vivian Salama, Cem Dede, Benjamin W. W. Edwards, Ruitao Lin, Brigid McDonald, Travis C. C. Salzillo, Renjie He, Yao Ding, Moamen Abobakr Abdelaal, Daniel Thill, Nicolette O'Connell, Virgil Willcut, John P. P. Christodouleas, Stephen Y. Y. Lai, Clifton D. D. Fuller, Abdallah S. R. Mohamed
Summary: This study compared different deformable image registration (DIR) methods for the co-registration of DWI and T2W MRI images in head and neck cancer patients. The results showed that the ADMIRE and Elastix 23 methods demonstrated superior performance in terms of registration accuracy and execution time, making them the preferred methods for registering T2W and DWI images acquired during the same scan session.
Article
Oncology
Linda A. Liang, Thomas Einzmann, Arno Franzen, Katja Schwarzer, Gunther Schauberger, Dirk Schriefer, Kathrin Radde, Sylke R. Zeissig, Hans Ikenberg, Chris J. L. M. Meijer, Charles J. Kirkpatrick, Heinz Koelbl, Maria Blettner, Stefanie J. Klug
Summary: The study compared the strategies of stand-alone HPV testing and cotesting for cervical cancer screening in a population-based study in Germany. The results showed that cotesting had higher sensitivity but also resulted in more false positive results and colposcopy referrals compared to stand-alone HPV testing.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emil Y. Sidky, Xiaochuan Pan
Summary: This report summarizes the 2022 AAPM Grand Challenge on Deep-Learning spectral Computed Tomography (DL-CT) image reconstruction. The challenge aims to develop accurate image reconstruction algorithms for the inverse problem of fast kilovolt switching dual-energy CT scan. Participants can use DL, iterative, or hybrid approaches.
Article
Oncology
Satish Munigala, Andrew J. Schoenfeld, Vivitha Mani, Amanda Banaag, Ada Umoh, Christian L. Coles, Tracey Perez Koehlmoos
Summary: The COVID-19 pandemic has resulted in a decrease in CRC screening rates, with variations observed across racial/ethnic groups and socioeconomic strata.
Review
Oncology
Niyati Lobo, Luca Afferi, Marco Moschini, Hugh Mostafid, Sima Porten, Sarah P. Psutka, Shilpa Gupta, Angela B. Smith, Stephen B. Williams, Yair Lotan
Summary: Bladder cancer is the tenth most common cancer worldwide, with a higher incidence in men than women. Tobacco smoking is the primary risk factor, accounting for approximately 50% of cases. Routine screening is not recommended, but targeted screening for high-risk individuals may reduce mortality. Smoking cessation is the most important prevention measure.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christine Lamoureux, Jennifer Mahoney, Scott Weber, Jamlik-Omari Johnson, Tarek N. Hanna
Summary: The study investigated the relationships between radiologist opinions of a quality assurance program, QA Committee communications, negative emotions, self-identified risk factors, and preventative actions taken following major errors. Results showed that radiologist opinions of the institutional QA process were influenced by the number of negative emotions experienced and preventative actions taken after major errors. Nurturing trust and incorporating more positive feedback in the QA process may improve interactions with QA Committees and reduce future errors.
ACADEMIC RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Elisabeth Waldmann, Andreas A. Kammerlander, Irina Gessl, Daniela Penz, Barbara Majcher, Anna Hinterberger, Michael Bretthauer, Michael H. Trauner, Monika Ferlitsch
Summary: The study found that high-quality colonoscopy is associated with a lower risk of CRC death, with the impact of ADR being strongest for individuals with high-risk adenomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
M. Rafiqul Islam, Mehrdad Shahmohammadi Beni, Chor-Yi Ng, Masayasu Miyake, Mahabubur Rahman, Shigeki Ito, Shinichi Gotoh, Taiga Yamaya, Hiroshi Watabe
Summary: The Monte Carlo method is used to simulate proton irradiation of a water-gel phantom in this study. Positron-emitting radionuclides, including C-11, O-15, and N-13, are scored using the Particle and Heavy Ion Transport Code System Monte Carlo code package. The results show an offset distance between the N-13 peak and the actual Bragg peak for different incident proton energies, which is further analyzed using an open-source computer program. Spectral analysis is performed to reconstruct the N-13 Bragg peak, and the obtained results are consistent with Monte Carlo computations. These findings and methodologies are important for future investigations in proton range monitoring for therapeutic applications.
Review
Oncology
Marta Maes-Carballo, Manuel Garcia-Garcia, Manuel Martin-Diaz, Carlos Roberto Estrada-Lopez, Andres Iglesias-Alvarez, Carmen Milagros Filigrana-Valle, Khalid Saeed Khan, Aurora Bueno-Cavanillas
Summary: This study evaluated the quality and reporting of colorectal cancer screening clinical practice guidelines and consensus statements. The findings showed low quality and reporting in these guidelines, highlighting the need for revision and improvement. Guidelines that utilized systematic reviews demonstrated better quality and reporting.
BRITISH JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Antonio Facciorusso, Joshua Demb, Babu P. Mohan, Samir Gupta, Siddharth Singh
Summary: This systematic review and meta-analysis of 8 randomized clinical trials with 110,644 participants found that adding financial incentives to promotion interventions may lead to a modest increase in colorectal cancer screening completion rates. However, there was no clear benefit observed in underserved populations with adverse social determinants of health.
Article
Oncology
Diama B. Vale, Ahti Anttila, Antonio Ponti, Carlo Senore, Rengaswamy Sankaranaryanan, Guglielmo Ronco, Nereo Segnan, Mariano Tomatis, Maja P. Zakelj, Klara M. Elfstrom, Stefan Lonnberg, Joakim Dinner, Partha Basu
EUROPEAN JOURNAL OF CANCER PREVENTION
(2019)
Article
Public, Environmental & Occupational Health
Ondrej Majek, Ahti Anttila, Marc Arbyn, Evert-Ben van Veen, Birgit Engesaeter, Stefan Lonnberg
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2019)
Article
Oncology
Eva Steliarova-Foucher, Miranda M. Fidler, Murielle Colombet, Brigitte Lacour, Peter Kaatsch, Marion Pineros, Isabelle Soerjomataram, Freddie Bray, Jan Willem Coebergh, Rafael Peris-Bonet, Charles A. Stiller
Article
Gastroenterology & Hepatology
Carlo Senore, Partha Basu, Ahti Anttila, Antonio Ponti, Mariano Tomatis, Diama Bhadra Vale, Gugliemo Ronco, Isabelle Soerjomataram, Maja Primic-Zakelj, Emilia Riggi, Joakim Dillner, Miriam Klara Elfstrom, Stefan Lonnberg, Rengaswamy Sankaranarayanan, Nereo Segnan
Article
Oncology
A. M. J. Reedijk, K. Klein, J. W. W. Coebergh, L. C. Kremer, A. G. Dinmohamed, V de Haas, A. B. Versluijs, G. J. Ossenkoppele, H. B. Beverloo, R. Pieters, C. M. Zwaan, G. J. L. Kaspers, H. E. Karim-Kos
Review
Oncology
Olaf Ortmann, Julie Torode, Chris Harrison, Johannes Bruns, Ulrike Helbig, Nicolas Philippou, Stefan Schreck, Tit Albreht, Josep Borras, Jan-Willem Coebergh, Andreas Hochhaus, Monika Klinkhammer-Schalke, Christoph Kowalski, Margarete Landenberger, Katrin Mugele, Ralf Rambach
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Letter
Respiratory System
Joannie Lortet-Tieulent, Isabelle Soerjomataram, Jose Luis Lopez-Campos, Julio Ancochea, Jan Willem Coebergh, Joan B. Soriano
EUROPEAN RESPIRATORY JOURNAL
(2019)
Article
Hematology
Ardine M. J. Reedijk, Eline A. M. Zijtregtop, Jan Willem W. Coebergh, Friederike A. G. Meyer-Wentrup, Konnie M. Hebeda, C. Michel Zwaan, Geert O. R. Janssens, Rob Pieters, Wouter J. Plattel, Avinash G. Dinmohamed, Josee M. Zijlstra, Leontien C. M. Kremer, Pieternella J. Lugtenburg, Auke Beishuizen, Henrike E. Karim-Kos
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Oncology
M. L. Tas, A. M. J. Reedijk, H. E. Karim-Kos, L. C. M. Kremer, C. P. van de Ven, M. P. Dierselhuis, N. K. A. van Eijkelenburg, M. van Grotel, K. C. J. M. Kraal, A. M. L. Peek, J. W. W. Coebergh, G. O. R. Janssens, B. de Keizer, R. R. de Krijger, R. Pieters, G. A. M. Tytgat, M. M. van Noesel
EUROPEAN JOURNAL OF CANCER
(2020)
Review
Oncology
O. Ortmann, J. Torode, W. Schmiegel, C. Thomssen, M. Hakama, P. Basu, U. Ringborg, U. Helbig
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Oncology
M. J. Reedijk Ardine, Leontien C. Kremer, Otto Visser, Valery Lemmens, Rob Pieters, Jan Willem W. Coebergh, Henrike E. Karim-Kos
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Ardine M. J. Reedijk, Jan Willem W. Coebergh, Hester A. de Groot-Kruseman, Inge M. van der Sluis, Leontien C. Kremer, Henrike E. Karim-Kos, Rob Pieters
Summary: The epidemiologic progress against childhood and adolescent acute lymphoblastic leukemia in the Netherlands showed stable overall incidence rates, despite increases in certain subtypes in different age groups. The survival rates for patients have improved, while the mortality rates have decreased, primarily due to treatment in pediatric oncology centers.
Correction
Oncology
O. Ortmann, J. Torode, W. Schmiegel, C. Thomssen, M. Hakama, P. Basu, U. Ringborg, U. Helbig
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Veli-Matti Partanen, Sirpa Heinavaara, Ahti Anttila, Jenni Hakkarainen, Stefan Lonnberg
Summary: This study corrected the incidence and mortality figures of cervix and corpus uteri cancers in Nordic countries by reallocating unspecified uterine cancer deaths and cases. The reallocation significantly impacted the number of cases and deaths for both cancers, with Finland being the only country where mortality rate did not substantially increase after reallocation. Efforts to validate cause of death data with incidence data from cancer registries are warranted to avoid erroneous conclusions based on uncorrected cancer burden.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Oncology
Ardine M. J. Reedijk, Auke Beishuizen, Jan Willem W. Coebergh, Bianca A. W. Hoeben, Leontien C. M. Kremer, Konnie M. Hebeda, Rob Pieters, Jan L. C. Loeffen, Henrike E. Karim-Kos
Summary: This population-based epidemiological study in the Netherlands shows significant progress against childhood and young adolescent NHL since 1990. The incidence of NHL has decreased among children aged 5-9, while survival rates have improved and mortality rates have steadily decreased over time.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)