Review
Food Science & Technology
Ivone Lima Santos, Antonio Manoel da Cruz Rodrigues, Edna Regina Amante, Luiza Helena Meller da Silva
Summary: This study discusses the chemical composition of soursop fruit and its by-products, as well as potential applications such as soursop powder, bioactive compounds, oil, biochar, biodiesel, and bio-oil. These by-products are rich in phytochemicals and have the potential to reduce environmental impact and generate income.
Article
Chemistry, Multidisciplinary
Gabriela Aguilar-Hernandez, Brandon A. Lopez-Romero, Alejandro Perez-Larios, Jose M. Ruvalcaba-Gomez, Inkar Castellanos-Huerta, Guillermo Tellez-Isaias, Victor M. Petrone-Garcia, Luis M. Anaya-Esparza, Efigenia Montalvo-Gonzalez
Summary: This study evaluated the antimicrobial effect of crude extract (CE) and purified acetogenins (P-ACGs) from the endosperm of A. muricata seeds against Gram-positive and Gram-negative microorganisms. The results showed that P-ACGs had strong antibacterial activity against several microorganisms, with a minimum inhibitory concentration ranging from 0.009 to 12.50 μg/mL. Additionally, P-ACGs caused significant sub-lethal damage in certain bacteria.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Brandon Alexis Lopez-Romero, Gabriel Luna-Barcenas, Maria De Lourdes Garcia-Magana, Luis Miguel Anaya-Esparza, Luis Gerardo Zepeda-Vallejo, Ulises Miguel Lopez-Garcia, Rosa Isela Ortiz-Basurto, Gabriela Aguilar-Hernandez, Alejandro Perez-Larios, Efigenia Montalvo-Gonzalez
Summary: The optimal conditions for extracting the highest TAC and yield from A. muricata seeds were determined using the TSAE method. Compared to other extraction methods, TSAE showed higher efficiency in extracting ACGs with antioxidant capacity. The isolated ACGs exhibited good solubility and significant antifungal activity.
Article
Pharmacology & Pharmacy
Wai-Jo Jocelin Chan, Joanna E. Harnett, Alexandra Meroni, Andrew J. McLachlan, Jane R. Hanrahan
Summary: This study investigated the quality and safety of commercially available A. muricata leaf products and found that one product did not meet the label requirements and there were variations in dosage recommendations. The indicators of quality and safety of these herbal products showed a high degree of variation, which has significant implications for clinicians and cancer patients who use these products.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Anuoluwa Abimbola Akinsiku, Ruth Opiotu Odaudu, Opeyemi Christianah De Campos, Alaba Oladipupo Adeyemi, Oluwaseun Ejilude
Summary: The study utilized Annona muricata aqueous extract as a reducing agent to synthesize bimetallic silver-cobalt nanoparticles. The extract was obtained by hot extraction using distilled water on the locally sourced plant. The nanoparticles were characterized using various techniques, and their effects on fly survival and antimicrobial activity were evaluated.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Shashanka K. Prasad, Sushma Pradeep, Chandan Shimavallu, Shiva Prasad Kollur, Asad Syed, Najat Marraiki, Chukwuebuka Egbuna, Mihnea-Alexandru Gaman, Olga Kosakowska, William C. Cho, Kingsley Chukwuemeka Patrick-Iwuanyanwu, Joaquin Ortega Castro, Juan Frau, Norma Flores-Holguin, Daniel Glossman-Mitnik
Summary: Annona muricata, a tropical plant with extensive medicinal use, exhibits significant antiviral properties and selective cytotoxicity against tumorigenic cells. Researchers have developed a unique library of bioactive compounds exclusive to A. muricata for in silico evaluations against the SARS-CoV-2 spike protein. The Acetogenins from A. muricata show promising potential as anti-SARS-CoV-2 agents and warrant further in vitro and in vivo studies.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Maria G. Gonzalez-Pedroza, Liliana Argueta-Figueroa, Rene Garcia-Contreras, Yaiza Jimenez-Martinez, Eduardo Martinez-Martinez, Saul A. Navarro-Marchal, Juan A. Marchal, Raul A. Morales-Luckie, Houria Boulaiz
Summary: In this study, silver nanoparticles were successfully synthesized using extracts from Annona muricata, showing a more potent anti-tumor effect in fruit peel extract compared to leaf extract. The nanoparticles demonstrated significant cancer cell destruction capabilities at low concentrations, making them a promising and cost-effective tool for cancer treatment.
Review
Chemistry, Medicinal
Patricia Martin del Campo-Rayas, Elia Herminia Valdez Miramontes, Zyanya Reyes Castillo
Summary: This study systematically analyzed the scientific evidence of the hypoglycemic effect of bioactive compounds in Annona muricata extracts and explored the factors affecting the composition of these compounds in different extracts. The study found that the hypoglycemic function involves multiple molecular-level effects, which are influenced by factors such as the content of plant bioactive compounds, extraction method, and consumer characteristics.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Biochemistry & Molecular Biology
Kingsley Chukwunonso Agu, Merit Ayevbuomwan, Rose Osarieme Imade, Paulinus Ngozi Okolie, Olusola Olalekan Elekofehinti, Abiodun Falodun, Lauretta Nkeiruka Eluehike, Mercy Chinaza Tasie, John Jatto Ovie, Sarah Kelechi Obiajuru, Oghenebrozie Reke Enakeno, Joyce Amiosinor Otsupius, Amina Isimenmen Kashetu, Faith Ofure Akeiti
Summary: This research explores the potential of Annona muricata in the treatment of sickle cell disease (SCD). Both in vitro and in silico experiments were conducted to evaluate its antioxidant and anti-sickling activities and its interaction with 2,3-bisphosphoglycerate (2,3-BPG) mutase and deoxyhaemoglobin. The results suggest that the ethyl acetate and chloroform fractions of Annona muricata possess promising therapeutic properties for SCD, and the compound 15-acetyl guanacone shows potential as a targeted therapy for the disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Ana Dacil Marrero, Ana R. Quesada, Beatriz Martinez-Poveda, Miguel Angel Medina, Casimiro Cardenas
Summary: This study used metabolomic and proteomic approaches to identify new bioactivities of aqueous and DMSO extracts from Annona muricata leaves, highlighting changes in cell cycle and iron metabolism. The experimental data also showed that DMSO extracts protected fibrosarcoma cells and endothelial cells from ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Ganiyu Akinniyi, Jeonghee Lee, Hiyoung Kim, Joon-Goo Lee, Inho Yang
Summary: Ipomoea pes-caprae is a halophytic plant that grows in tropical and subtropical countries. It is used in traditional medicine and has pharmacologically active components. This review aims to facilitate further studies and the discovery of novel bioactive natural products from this plant.
Review
Biochemistry & Molecular Biology
Mutakin Mutakin, Rizky Fauziati, Fahrina Nur Fadhilah, Ade Zuhrotun, Riezki Amalia, Yuni Elsa Hadisaputri
Summary: This review discusses the traditional use, chemical content, and pharmacological activities of Soursop (Annona muricata Lin.). Studies have shown that Soursop has various activities, including anticancer, antiulcer, and antidiabetic effects. The plant contains chemicals such as acetogenins, alkaloids, flavonoids, and vitamins, which are predicted to be responsible for its biological activity.
Article
Chemistry, Applied
Chengyao Ma, Yue Li, Jiahui Lu, Maolin Wang, Xiang Li, Jianwei Chen, Yong Chen, Wenzheng Ju
Summary: Three new annonaceous acetogenins were isolated from the seeds of Annona squamosa Linn., and their structures were determined. Among them, compound 3 exhibited strong cytotoxicity against three multidrug-resistant cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Alexandra G. Duran, M. Teresa Gutierrez, Francisco J. R. Mejias, Jose M. G. Molinillo, Francisco A. Macias
Summary: Annona cherimola Mill., also known as the custard apple, belongs to the Annonaceae family and is widely used in traditional medicine for its bioactive compounds. Among these compounds, Annonaceous acetogenins are considered to be highly potent antitumor compounds, making them valuable in cancer research. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application, and synthetic derivatives of acetogenins from A. cherimola Mill.
Article
Food Science & Technology
Brandon Alexis Lopez-Romero, Guillermo Tellez-Isaias, Gabriel Luna-Barcenas, Adalberto Zamudio-Ojeda, Gilberto Velazquez-Juarez, Maria de Lourdes Garcia-Magana, Gabriela Aguilar-Hernandez, Efigenia Montalvo-Gonzalez
Summary: This study successfully developed nanosuspensions as carriers of ACGs, which showed potential for improving the solubility and bioavailability of ACGs in pharmaceutical applications.
CYTA-JOURNAL OF FOOD
(2023)
Article
Public, Environmental & Occupational Health
Yahaya Gavamukulya, Faten Abou-Elella, Fred Wamunyokoli, Hany AEl-Shemy
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2014)
Article
Infectious Diseases
Paul Oboth, Yahaya Gavamukulya, Banson John Barugahare
BMC INFECTIOUS DISEASES
(2019)
Article
Polymer Science
Yahaya Gavamukulya, Esther N. Maina, Amos M. Meroka, Edwin S. Madivoli, Hany A. El-Shemy, Fred Wamunyokoli, Gabriel Magoma
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Polymer Science
Edwin Shigwenya Madivoli, Patrick Gachoki Kareru, Anthony Ngure Gachanja, Samuel Mutuura Mugo, David Sujee Makhanu, Sammy Indire Wanakai, Yahaya Gavamukulya
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Review
Integrative & Complementary Medicine
Samuel Baker Obakiro, Ambrose Kiprop, Elizabeth Kigondu, Isaac K'Owino, Mark Peter Odero, Scolastica Manyim, Timothy Omara, Jane Namukobe, Richard Oriko Owor, Yahaya Gavamukulya, Lydia Bunalema
Summary: Erythrina abyssinica is an important ethnomedicinal plant in Africa with pharmacologically active phytochemicals against various diseases, showing significant efficacy and minimal toxicity to mammalian cells. Continued research and clinical trials are recommended to explore its potential for developing novel molecules against diseases.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Erina Kisakye, Yahaya Gavamukulya, Banson John Barugahare
Summary: The uptake of sickle cell trait screening among university students aged 18 to 35 in Uganda was found to be low. Most students had a high level of knowledge regarding sickle cell disease/SCTS and showed a positive attitude towards SCTS. Older age and marital status were associated with a higher likelihood of being screened.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Biology
Christine H. Namugerwa, Yahaya Gavamukulya, Banson John Barugahare
Summary: This study investigated the knowledge and attitude towards sickle cell disease among care givers of paediatric sickle cell patients at Mbale regional referral hospital in Uganda. The results showed a high level of general awareness about SCD/SCA, but limited knowledge about its cause and prevention, and most participants did not consider it a factor in their marital decisions.
BMC RESEARCH NOTES
(2023)
Article
Tropical Medicine
Emily Tumwakire, Scholastic Ashaba, Vincent Mubangizi, Yahaya Gavamukulya
Summary: There is a lack of knowledge on the sexual and reproductive health of youth with mental illness in low-income countries. This study found that youth with mental illness have lower sexual and reproductive health knowledge compared to those without mental illness in South Western Uganda. They also tend to engage in risky sexual behavior.
TROPICAL MEDICINE AND HEALTH
(2022)
Article
Multidisciplinary Sciences
Yahaya Gavamukulya, Hany A. El-Shemy, Amos M. Meroka, Edwin S. Madivoli, Esther N. Maina, Fred Wamunyokoli, Gabriel Magoma
Article
Multidisciplinary Sciences
Brenda Wafana Nabwana, Sylvia Sidney Namayanja, Collette Kemigisha, Erina Kisakye, Amos Kuddiza Kusetula, Silvester Wakabi, Ivan Wambi, Innocent Musiime, Rebecca Nekaka, Yahaya Gavamukulya
Article
Multidisciplinary Sciences
Yahaya Gavamukulya, Esther N. Maina, Amos M. Meroka, Hany A. El-Shemy, Gabriel Magoma, Fred Wamunyokoli