Review
Biochemistry & Molecular Biology
John R. Couchman
Summary: Cell surface proteoglycans, such as syndecans, play crucial roles in regulating cell behavior, including interactions with extracellular matrix components and mediating proliferation, adhesion, and migration. In tumors, changes in the levels and distribution of syndecan-1 can have implications for prognosis, with loss of membrane staining and abnormal cytoplasmic or nuclear staining often indicating poor outcomes. Targeting syndecan-1 with antibody-toxin conjugates may hold promise for clinical applications in both myeloma and some carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Kelvin Y. C. Yu, Susan Yung, Mel K. M. Chau, Colin S. O. Tang, Desmond Y. H. Yap, Alexander H. N. Tang, Shirley K. Y. Ying, Cheuk Kwong Lee, Tak Mao Chan
Summary: The study found that levels of syndecan-1, HA, and thrombomodulin were significantly elevated in patients with active lupus nephritis and correlated with various clinical parameters. Longitudinal studies showed that syndecan-1 and thrombomodulin levels increased before clinical renal flare, while HA levels increased at the time of nephritic flare. These biomarkers have the potential to differentiate between active lupus nephritis and other conditions, and may provide insight into the pathogenesis of the disease.
Review
Cell Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Aberrant expression of syndecan-4 is associated with worse prognosis in breast cancer. It is regulated by various mechanisms, including transcriptional and posttranscriptional mechanisms. Syndecan-4 plays a crucial role in breast cancer progression by interacting with different ligands and regulating cellular processes such as adhesion, migration, and invasion. Additionally, syndecan-4 expression is modulated by drugs used in breast cancer treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mona Sheta, Martin Goette
Summary: This review summarizes the current understanding of breast carcinogenesis in correlation with Syndecan-1 expression, the mechanisms involved, and proposed therapeutic strategies against Syndecan-1-related malignancy.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Keiko Suzuki, Hideshi Okada, Kazuyuki Sumi, Hiroyuki Tomita, Ryo Kobayashi, Takuma Ishihara, Yoshinori Kakino, Kodai Suzuki, Naomasa Yoshiyama, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Haruka Okamoto, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Shinji Ogura, Akio Suzuki
Summary: The study found that changing serum SDC-1 levels can help early detection of organ dysfunction in critically ill patients, with significant effects on multiple outcomes seen from the previous day's SDC-1 levels. Furthermore, increasing levels of SDC-1 were identified as a significant risk factor for mortality.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu
Summary: The upregulation of CHPF in breast cancer contributes to malignant behavior of cancer cells, promoting tumor growth and metastasis. Co-localization of tumor cell-derived G-CSF with CS on the cell surface was found. Breast cancer patients with high expression of both SDC4 and CHPF had worse overall survival, indicating synergistic effects of these two genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Ying Zhong, Fangyuan Li, Sumei Zhang, Zhenli Yang, Xinyu Ren, Xi Cao, Yali Xu, Dan Guo, Yidong Zhou, Feng Mao, Songjie Shen, Qiang Sun
Summary: This study revealed that SDC1 is a key immune-related gene that is highly expressed in triple-negative breast cancer patients. Patients with high SDC1 expression in tumor cells and low expression in cancer associated fibroblasts (CAFs) had worse prognosis and lower tumor-infiltrating lymphocytes (TILs). Additionally, SDC1 was found to regulate the migration of MDA-MB-231 breast cancer cells through a TGFb1-Smad and E-cadherin-dependent mechanism.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Riordan Azam, David Lim, Belinda Curpen, Anne-Marie Mulligan, Nicole Look Hong
Summary: Current imaging techniques show poor correlation with final surgical pathology, leading to potential uncertainty in surgical excision and exclusion of non-surgical management candidates. Triple-negative breast cancer (TNBC) is a good candidate for ongoing trials due to stronger correlations between pathology and imaging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Zecheng Yang, Shuaitong Chen, Haoqiang Ying, Wantong Yao
Summary: This review summarizes the current knowledge on the structure and functions of Syndecan-1 (SDC1) and its role in tumor biology. The review highlights the critical role of SDC1 in promoting tumorigenesis and metastasis, and emphasizes the potential of utilizing SDC1 as a novel target for cancer therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Minna Mutka, Reetta Virtakoivu, Kristiina Joensuu, Maija Hollmen, Paivi Heikkila
Summary: The expression of intratumoral Clever-1 + macrophages is associated with better prognosis in breast cancer. The presence of higher number of Clever-1 + cells correlates with high grade tumors and hormone receptor negative tumors, as well as with increased TILs. The findings suggest that M2 macrophages may modulate tumor stroma and maintain immune response balance to prevent excess inflammation.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Yi-Zi Zheng, Xian-Ming Wang, Lei Fan, Zhi-Ming Shao
Summary: This study found that for stage IV breast cancer, smaller primary tumors may not always be associated with better breast cancer-specific mortality. Particularly in triple-negative breast cancers (TNBCs), very small tumors with extensive regional lymph node involvement may indicate biologically aggressive disease.
Article
Multidisciplinary Sciences
Gia Deyab, Trine Marita Reine, Tram Thu Vuong, Trond Jenssen, Gunnbjorg Hjeltnes, Stefan Agewall, Knut Mikkelsen, Oystein Forre, Morten Wang Fagerland, Svein Olav Kolset, Ivana Hollan
Summary: The study found that treatment with disease-modifying antirheumatic drugs can decrease serum levels of syndecan-1 in patients with rheumatoid arthritis, reducing shedding of syndecan-1 from the endothelial glycocalyx and potentially providing cardioprotective effects.
Article
Medicine, Research & Experimental
Bruna Cerbelli, Annalinda Pisano, Maria Gemma Pignataro, Angelina Pernazza, Andrea Botticelli, Mariantonia Carosi, Leopoldo Costarelli, Matteo Allegretti, Giulia d'Amati, Iole Cordone
Summary: Syndecan-1 plays an important role in the metastasis of breast cancer. We observed a shift in cellular localization of syndecan-1, from diffuse cytoplasmic expression in primary breast cancer to membrane expression in metastatic lesions. We also found a correlation between tumor intrinsic subtypes and the extent of syndecan-1 positivity.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Analytical
Mengjia Hu, Virginia Brown, Joshua M. Jackson, Harshani Wijerathne, Harsh Pathak, Devin C. Koestler, Emily Nissen, Mateusz L. Hupert, Rolf Muller, Andrew K. Godwin, Malgorzata A. Witek, Steven A. Soper
Summary: Extracellular vesicles (EVs) have the potential to be used as a minimally invasive liquid biopsy marker for precision medicine, as they carry RNA cargo associated with the cell-of-origin. Researchers have developed an EV microfluidic affinity purification (EV-MAP) chip, made from plastic for high-scale production, which can isolate EV subpopulations. They demonstrated the utility of this chip in molecular subtyping breast cancer patients, isolating two subpopulations of EVs that better recapitulate the tumor microenvironment. The EV-MAP provided high recovery and specificity based on exosomal mRNA and PCR results, and the EV subpopulations showed potential for prognostication using the PAM50 test.
ANALYTICAL CHEMISTRY
(2023)
Article
Pathology
Doerthe Jechorek, Inken Haeusler-Pliske, Frank Meyer, Albert Roessner
Summary: SDC4 plays a crucial role in the progression of colorectal cancer, with high expression associated with aggressive pathological features and reduced survival rates. Research on its impact on patient prognosis may offer clinical utility, identifying potential therapeutic targets in the diagnosis and treatment of CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Immunology
Mohammad Reza Haghshenas, Hamid Ghaderi, Hossein Daneste, Abbas Ghaderi
Summary: Salivary glands play a crucial role in oral immunity. Immune components and responses in the tumor microenvironment of salivary gland tumors are being investigated. Immune checkpoint molecules and chemokines are potential targets for cancer immunotherapy.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amin Ramezani, Amir Asgari, Elina Kaviani, Ahmad Hosseini, Abbas Ghaderi
Summary: This study developed a new variant of the anti-ErbB2 antibody pertuzumab, named Tatibody, with a 3.6 fold higher internalization potency, making it a good candidate for ADC construction.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Atri Ghods, Fereshteh Mehdipour, Mahmoud Shariat, Abdol-Rasoul Talei, Abbas Ghaderi
Summary: In breast tumor-draining lymph nodes, most TNFR2(+)CD4(+) T lymphocytes are Foxp3(-)CD25(-), while the majority of Tregs are TNFR2(+) with the highest intensity of TNFR2 expression.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Faezeh Maghsood, Mohammad-Reza Shokri, Mahmood Jeddi-Tehrani, Monireh Torabi Rahvar, Abbas Ghaderi, Vahid Salimi, Gholam Ali Kardar, Amir-Hassan Zarnani, Mohammad Mehdi Amiri, Fazel Shokri
Summary: IgG responses to RBD and NP in COVID-19 patients were found to be dominated by conformational and linear epitopes, respectively. The reactivity of patients' sera with reduced recombinant RBD protein was significantly lower than the native form, while no significant differences were observed for NP protein. The identification of immunodominant epitopes in NP and RBD could be valuable for the development of immunotherapy and diagnostic tools for COVID-19.
PATHOGENS AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Mohammad Javad Fattahi, Mohammad Reza Haghshenas, Abbas Ghaderi
Summary: The initiation and progression of bladder cancer rely on its tumor microenvironment, which is influenced by immune cells. Immunometabolism plays a crucial role in immune cell function and immune response in bladder cancer. Understanding the metabolic reprogramming of bladder cancer cells and immune cells in the tumor microenvironment can provide new opportunities for targeted therapies.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Immunology
Atri Ghods, Fereshteh Mehdipour, Reza Rasolmali, Abdol-Rasoul Talei, Abbas Ghaderi
Summary: This study focused on the expression of membranous and intracellular forms of TNF-alpha in lymphocytes derived from breast cancer-draining lymph nodes. The results showed that CD4+T cells primarily express the membranous form, while CD8+T cells primarily express the intracellular form. The intensity of membranous TNF-alpha expression in CD19+ cells was correlated with poor prognosticators, and the frequency of membranous TNF-alpha+CD19+ cells showed an inverse correlation with the number of involved lymph nodes.
CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Marjan Hematian Larki, Elham Ashouri, Shaghik Barani, Seiyed Mohammad Ali Ghayumi, Abbas Ghaderi, Raja Rajalingam
Summary: The study reveals the association between KIR and HLA class I ligands with genetic predisposition to lung cancer in the native population of southern Iran. Specific KIR genes and HLA-C1 ligands show significant increase in patients with lung cancer, certain genotypes are positively correlated with disease risk, and iKIRs > aKIRs genotypes are more frequently presented in lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Yousef Mohammadi, Simin Ahmadvand, Maryam Mirtalebi, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi
Summary: The expression of TILs in larynx squamous cell carcinoma is associated with clinicopathological features and patient outcomes. CD45RO+ TILs, in particular, serve as independent prognostic markers and can predict risk and outcomes in patients with larynx SCC.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Thomas J. Webster, Abbas Ghaderi
Summary: Urothelial bladder cancer (UBC) is a complex malignancy with a high recurrence rate. Current diagnostic procedures lack sensitivity and specificity, thus biomarkers have potential value for early diagnosis, prognosis, and immunotherapy. Proteomics methods have rapidly advanced in identifying UBC biomarkers, and a panel of biomarkers may achieve higher diagnostic accuracy. This review evaluates recent literature on UBC proteomics, classifies tumor biomarkers based on their sources, and discusses the limitations and advantages of each source.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Amin Ramezani, Mohammadrasul Zareinejad, Elham Mahmoudi Maymand, Elina Kaviani, Abbas Ghaderi
Summary: This study aimed to produce a biosimilar version of aflibercept (AFL) and evaluate its effect when used in combination with other vascular endothelial growth factor (VEGF) blocker drugs. The biosimilar-AFL showed significant inhibition potential on HUVEC cells in a dose-dependent manner. Furthermore, co-treatment with Everolimus (EVR), Lenvatinib (LEN), and Sorafenib (SOR) enhanced the cytotoxicity of biosimilar-AFL on HUVEC cells, with LEN and SOR showing a 10-fold increase in cytotoxicity. The combination of biosimilar-AFL with LEN showed the most efficient result, while the combination with EVR showed the least efficient result. Overall, biosimilar-AFL may improve the efficacy of LEN, EVR, and SOR in reducing the VEGF effect on endothelial cells.
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Ali Ariafar, Kambiz Gilany, Allan Stensballe, Shirin Farjadian, Abbas Ghaderi
Summary: The aim of this study is to recognize tumor-associated proteins, which are differentially expressed in different stages of UBC patients compared to non-cancerous tissues. The study found significant changes in protein expression related to oxidative stress and antioxidant activity in UBC patients. These findings may contribute to the development of promising biomarkers for early detection, monitoring, and prognosis of UBC.
CLINICAL PROTEOMICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi
Summary: This study found that there is no direct correlation between the SNP of lncRNA ANRIL rs4977574 and the presence of oral squamous cell carcinoma (OSCC). However, it was observed that the SNP is associated with smaller tumor size and higher level of cancer cell differentiation.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Review
Medicine, Research & Experimental
Ensiye Torki, Arezou Gharezade, Mehrnoosh Doroudchi, Shima Sheikhi, Davood Mansury, Mark J. M. Sullman, Hamed Fouladseresht
Summary: The immune system is regulated by inhibitory immune checkpoints to prevent excessive immune responses, but chronic infections can result in sustained expression of these checkpoints, leading to reduced immune cell functioning and more severe disease complications. Pathogens can also exploit these immune checkpoints to evade immune mechanisms.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Hamid Ghaderi, Estie Kruger, Simin Ahmadvand, Yousef Mohammadi, Bijan Khademi, Abbas Ghaderi
Summary: This study conducted a comprehensive epidemiological analysis of salivary gland tumors in the south of Iran and found that benign tumors were the most prevalent type, with the parotid gland being the most common site. It also revealed that malignant tumors were more common among older patients.
JOURNAL OF CANCER EPIDEMIOLOGY
(2023)
Article
Cell Biology
Shahram Taeb, Mohammad Amin Mosleh-Shirazi, Abbas Ghaderi, Seyed Mohammad Javad Mortazavi, Mahboobeh Razmkhah
Summary: This study demonstrates that radiation can affect adipose-derived mesenchymal stem cells, potentially preventing tumor development and metastasis. The bystander effects of ASCs post-irradiation significantly impact cell activity and gene expression in different cancer cell lines.
