Article
Biochemistry & Molecular Biology
Helena Port, Anne-Christine Bay-Jensen, Yi He, Morten A. A. Karsdal, Thorbjorn Gantzel, Christian S. S. Thudium, Signe Holm Nielsen
Summary: The development of a competitive chemiluminescence enzyme-linked immunosorbent assay, CALC2, targeting the type II collagen C-terminal pro-peptide as a marker of cartilage formation was evaluated. The CALC2 level was measured after in vitro cleavage of recombinant type II collagen and treatment of human osteoarthritis cartilage explant model with insulin-like growth factor-1. Serum CALC2 levels were found to be decreased in patients with rheumatoid arthritis and ankylosing spondylitis compared to controls. These results suggest that CALC2 may be a novel biomarker of type II collagen formation, but further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Pang-Yen Liu, Chin Lin, Chin-Sheng Lin, Wen-Hui Fang, Chia-Cheng Lee, Chih-Hung Wang, Dung-Jang Tsai
Summary: The study aimed to develop an AI-ECG system to predict BNP/pBNP values in patients with cardiovascular diseases (CVDs) and compare their values for future mortality. The results showed that the AI-ECG accurately predicted BNP/pBNP values, and pBNP was a better predictor of future mortality.
Article
Cardiac & Cardiovascular Systems
Karola S. Jering, Brian L. Claggett, Marc A. Pfeffer, Christopher B. Granger, Lars Kober, Eldrin F. Lewis, Aldo P. Maggioni, Douglas L. Mann, John J. V. McMurray, Margaret F. Prescott, Jean L. Rouleau, Scott D. Solomon, Phillippe Gabriel Steg, Dirk von Lewinski, Eugene Braunwald
Summary: NT-proBNP is an important prognostic factor in patients with acute myocardial infarction and certain risk factors. It is associated with heart failure, death, and atherosclerotic events, and this predictive information is independent of hs-cTnT.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Review
Cardiac & Cardiovascular Systems
Pamela Nogueira Cavalcante, Gabriel Kanhouche, Vitor Emer Egypto Rosa, Carlos M. Campos, Mariana Pezzute Lopes, Maria Antonieta Albanez A. de M. Lopes, Roney Orismar Sampaio, Fabio Sandoli de Brito Jr, Flavio Tarasoutchi, Alexandre Antonio Cunha Abizaid
Summary: B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers released in response to increased ventricular and atrial wall stress. Studies have shown that elevated levels of these biomarkers are correlated with the severity of aortic stenosis (AS) and can predict the need for intervention. They play a crucial role in risk stratification and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Takaya Sasaki, Emi Oishi, Takuya Nagata, Satoko Sakata, Sanmei Chen, Yoshihiko Furuta, Takanori Honda, Daigo Yoshida, Jun Hata, Nobuo Tsuboi, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study found that higher serum NT-proBNP levels were associated with increased risks of developing chronic kidney disease (CKD) and a more rapid decline in estimated glomerular filtration rate (eGFR). In the general Japanese population, serum NT-proBNP could serve as a useful biomarker for assessing the future risk of CKD.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Rheumatology
Karim Sacre, Evelyne Vinet, Christian A. Pineau, Arielle Mendel, Fares Kalache, Louis-Pierre Grenier, Thao Huynh, Sasha Bernatsky
Summary: NT-proBNP is associated with cardiovascular damage in SLE patients and could serve as a biomarker for cardiovascular damage. NT-proBNP levels are associated with hypertension, dyslipidemia, age, smoking history, reduced eGFR, prior pericarditis/pleuritis, and aPL antibodies.
Article
Cardiac & Cardiovascular Systems
Hsin-Chia Lin, Shu-Chien Huang, Mei-Hwan Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-An Chen, Chun-Wei Lu, Yih-Sharng Chen, Shuenn-Nan Chiu
Summary: The role of preoperative N-terminal pro-brain natriuretic peptide level in patient outcomes after the Fontan operation was investigated in this study. The results showed that high preoperative N-terminal pro-brain natriuretic peptide was associated with poor outcomes after the operation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Peripheral Vascular Disease
Charles D. Nicoli, Timothy B. Plante, D. Leann Long, Suzanne E. Judd, Leslie A. McClure, Pankaj Arora, Mary Cushman
Summary: The REGARDS study found that NT-proBNP was not associated with incident hypertension, with consistent results across different demographic groups.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Medicine, General & Internal
Peter D. Mark, Martin Frydland, Ole Kristian Lerche Helgestad, Lene Holmvang, Jacob Eifer Moller, Par Johansson, Sisse R. Ostrowski, Timothy Prickett, Christian Hassager, Jens Peter Goetze
Summary: The study results show that in female patients presenting with ST-elevation myocardial infarction (STEMI), high plasma concentrations of pro-C-type natriuretic peptide (pro-CNP) on admission (>= median) independently indicate a higher risk of all-cause mortality. This finding is remarkably specific for female patients, suggesting a different vascular phenotype compared to male patients.
Article
Medicine, General & Internal
Anna Gudmundsdottir, Marco Bartocci, Oda Picard, Joanna Ekstrom, Alexander Chakhunashvili, Kajsa Bohlin, Caroline Attner, Gordana Printz, Mathias Karlsson, Lilly-Ann Mohlkert, Jonna Karlen, Cecilia Pegelow Halvorsen, Anna-Karin Edstedt Bonamy
Summary: This study aimed to investigate the association between gestational age (GA), echocardiographic markers, and plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) levels with the closure rate of a clinically significant patent ductus arteriosus (hsPDA). The results showed that the spontaneous closure rate of PDA is relatively high in extremely preterm infants. Early NTproBNP levels can be used in conjunction with GA to guide management decisions for hsPDA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Agnes-Sophie Fritz, Titus Keller, Angela Kribs, Christoph Huenseler
Summary: This observational study provides reference values for NT-proBNP levels of very and extremely preterm infants during their first weeks of life. NT-proBNP values during the first week of life in premature infants without complications depend on gestational age at birth.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Ching-Mao Chang, Jr-Rung Lin, Tieh-Cheng Fu
Summary: The study found that in the United States, patients diagnosed with RA are less likely to develop HF or MI compared to those with SLE. There was no significant association between sarcopenia and the presence of HF or MI.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jose Tunon, Ana Pello, Alvaro Acena, Sergio Ramos-Cillan, Juan Martinez-Milla, Oscar Gonzalez-Lorenzo, Jesus Fuentes-Antras, Nieves Tarin, Carmen Cristobal, Luis M. Blanco-Colio, Jose Luis Martin-Ventura, Ana Huelmos, Carlos Gutierrez-Landaluce, Marta Lopez-Castillo, Joaquin Alonso, Lorenzo Lopez Bescos, Jesus Egido, Ignacio Mahillo-Fernandez, Oscar Lorenzo
Summary: In patients with coronary artery disease, NT-proBNP was an independent predictor of receiving a cancer diagnosis in the first three years of follow-up, but not later, suggesting that it could be detecting subclinical undiagnosed cancers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Sport Sciences
Kohei Ashikaga, Kihei Yoneyama, Haruki Musha, Yoshihiro J. Akashi, Takashi Kawahara
Summary: The study revealed an association between left ventricular hypertrophy (LVH) in athletes and future hypertension, with smoking history potentially affecting this relationship. LVH may not be an independent factor for incident hypertension among elite athletes, emphasizing the importance of considering smoking as a confounding factor.
SPORT SCIENCES FOR HEALTH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Takayuki Warisawa, Yoshiaki Kawase, Ryosuke Itakura, Yoshihiro J. Akashi, Hitoshi Matsuo
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Cesare de Gregorio, Lorenzo Pistelli, Marco Borgi, Olimpia Trio, Yoshihiro J. Akashi, Giuseppe Ando
Summary: TakoTsubo Syndrome is a stress-induced cardiac disease characterized by temporary left ventricle dysfunction. It primarily affects post-menopause women and shares similar symptoms with acute coronary syndrome. The underlying mechanisms are still debated, with catecholamine-induced cardiotoxicity and microvascular dysfunction being the most proposed hypotheses. The recovery time for TTS is long and there is a risk of recurrence. No effective drugs have been found to reduce mortality, improve outcomes, or prevent recurrences in TTS.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Hiroyoshi Mori, Takuya Mizukami, Atsuo Maeda, Kazuki Fukui, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Kouichi Tamura, Atsuo Namiki, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
Summary: The 1-year rates of ischemic and bleeding events were similar in Japanese patients with AMI treated with prasugrel or clopidogrel.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kohei Ashikaga, Haruki Itoh, Tomoko Maeda, Hidetaka Itoh, Shiori Tanaka, Yuri Ichikawa, Masatoshi Nagayama, Yoshihiro J. Akashi, Mitsuaki Isobe
Summary: The ventilatory efficiency for carbon dioxide output during exercise is an important prognostic index in patients with chronic heart failure. This study investigated the usefulness of the predicted value of the percentage VE vs.VCO2 slope as a prognostic index. The results showed that a %VE vs.VCO2 slope > 120 was an independent predictor of cardiovascular-related death.
Article
Cardiac & Cardiovascular Systems
Shinji Nemoto, Yusuke Kasahara, Kazuhiro P. Izawa, Satoshi Watanabe, Kazuya Yoshizawa, Naoya Takeichi, Keigo Akao, Sato Watanabe, Kei Mizukoshi, Norio Suzuki, Kohei Ashikaga, Keisuke Kida, Naohiko Osada, Yoshihiro J. Akashi
Summary: This study aimed to investigate whether hospitalization in older patients with heart failure (HF) leads to a worsening of independence in activities of daily living (ADL) and difficulties in ADL, and whether these difficulties can predict readmission for HF. The results showed that hospitalization triggered a decline in independence and an increase in difficulties in ADL in older HF patients, and these difficulties were relevant factors for the risk of readmission.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroyoshi Mori, Kaoru Sakurai, Yuji Ikari, Kazuki Fukui, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Toshiaki Ebina, Kouichi Tamura, Atsuo Namiki, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
Summary: The study analyzed data from a Japanese registry to compare the outcomes of patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) with radial access and femoral access. The results showed that radial access was associated with lower rates of major adverse cardiac event (MACE), bleeding events, and composite events.
JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shigeru Makita, Takanori Yasu, Yoshihiro J. Akashi, Hitoshi Adachi, Hideo Izawa, Shunichi Ishihara, Yoshitaka Iso, Hideo Ohuchi, Kazuto Omiya, Yusuke Ohya, Koichi Okita, Yutaka Kimura, Akira Koike, Masahiro Kohzuki, Shinji Koba, Masataka Sata, Kazunori Shimada, Tomoki Shimokawa, Hirokazu Shiraishi, Naokata Sumitomo, Tetsuya Takahashi, Tomoyuki Takura, Hiroyuki Tsutsui, Masatoshi Nagayama, Emiko Hasegawa, Yoshihiro Fukumoto, Yutaka Furukawa, Shin-ichiro Miura, Satoshi Yasuda, Sumio Yamada, Yuichiro Yamada, Dai Yumino, Toshiko Yoshida, Takuji Adachi, Toshimi Ikegame, Kazuhiro P. Izawa, Takeshi Ishida, Neiko Ozasa, Naohiko Osada, Hiroaki Obata, Naoya Kakutani, Yusuke Kasahara, Masaaki Kato, Kentaro Kamiya, Shintaro Kinugawa, Yuji Kono, Yasuyuki Kobayashi, Teruyuki Koyama, Kazuhiro Sase, Shinji Sato, Tatsuhiro Shibata, Norio Suzuki, Daisuke Tamaki, Minako Yamaoka-Tojo, Michio Nakanishi, Eisaku Nakane, Mari Nishizaki, Taiki Higo, Kanta Fujimi, Tasuku Honda, Yasuharu Matsumoto, Noriko Matsumoto, Ikuko Miyawaki, Makoto Murata, Shusuke Yagi, Masanobu Yanase, Midori Yamada, Miho Yokoyama, Noboru Watanabe, Haruki Ito, Takeshi Kimura, Syunei Kyo, Yoichi Goto, Ryuji Nohara, Ken-Ichi Hirata
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yasuhiro Tanabe, Mitsuyoshi Takahara, Shun Kohsaka, Toshiro Shinke, Itaru Takamisawa, Tetsuya Amano, Hideaki Kanazawa, Tomomi Suzuki, Shingo Kuwata, Yuki Ishibashi, Yoshihiro J. Akashi, Yuji Ikari
Summary: This study analyzed data from 2,859 consecutive cases undergoing percutaneous ASD closure between January 2015 and December 2020. The success rates and complication rates were similar in the TEE, ICE, and both groups. However, a higher proportion of patients in the TEE and both groups required general anesthesia. The use of ICE was associated with larger defect diameter and higher hospital volume.
CIRCULATION JOURNAL
(2023)
Correction
Cardiac & Cardiovascular Systems
Shigeru Makita, Takanori Yasu, Yoshihiro J. Akashi, Hitoshi Adachi, Hideo Izawa, Shunichi Ishihar, Yoshitaka Iso, Hideo Ohuchi, Kazuto Omiy, Yusuke Ohya, Koichi Okita, Yutaka Kimura, Akira Koike, Masahiro Kohzuki, Shinji Koba, Masataka Sata, Kazunori Shimada, Tomoki Shimokawa, Hirokazu Shiraishi, Naokata Sumitomo, Tetsuya Takahashi, Tomoyuki Takura, Hiroyuki Tsutsui, Masatoshi Nagayama, Emiko Hasegawa, Yoshihiro Fukumoto, Yutaka Furukawa, Shin-ichiro Miura, Satoshi Yasuda, Sumio Yamada, Yuichiro Yamada, Dai Yumino, Toshiko Yoshida, Takuji Adachi, Toshimi Ikegame, Kazuhiro P. Izawa, Takeshi Ishida, Neiko Ozasa, Naohiko Osada, Hiroaki Obata, Naoya Kakutani, Yusuke Kasahara, Masaaki Kato, Kentaro Kamiya, Shintaro Kinugawa, Yuji Kono, Yasuyuki Kobayash, Teruyuki Koyama, Kazuhiro Sase, Shinji Sato, Tatsuhiro Shibata, Norio Suzuki, Daisuke Tamaki, Minako Yamaoka-Tojo, Michio Nakanishi, Eisaku Nakane, Mari Nishizaki, Taiki Higo, Kanta Fujimi, Tasuku Honda, Yasuharu Matsumoto, Noriko Matsumoto, Ikuko Miyawaki, Makoto Murata, Shusuke Yagi, Masanobu Yanase, Midori Yamad, Miho Yokoyama, Noboru Watanabe, Haruki Itoh, Takeshi Kimura, Syunei Kyo, Yoichi Goto, Ryuji Nohar, Ken-Ichi Hirata
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Kohei Ashikaga, Haruki Itoh, Tomoko Maeda, Yuri Ichikawa, Shiori Tanaka, Akira Koike, Shigeru Makita, Kazuto Omiya, Yuko Kato, Hitoshi Adachi, Masatoshi J. Nagayama, Yoshihiro Akashi
Summary: Circulatory power (CP) and ventilatory power (VP) obtained from cardiopulmonary exercise testing are valuable prognostic markers for heart failure. However, the normal values of these parameters in healthy Japanese populations are unclear. This study investigated the values of CP and VP in a cohort of 391 healthy Japanese participants, providing reference values for evaluating CPX results in patients.
Editorial Material
Cardiac & Cardiovascular Systems
Shingo Ito, Yasuhiro Tanabe, Kan Nawata, Kumi Oshima, Yoshihiro J. Akashi
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yasuhito Kawagoe, Makoto Nishimori, Soshiro Ogata, Masakazu Shinohara, Yoshihiro J. Akashi, Yoshio Tahara
Meeting Abstract
Cardiac & Cardiovascular Systems
Toru Nakanishi, Dan Koto, Mizuho Kasahara, Kei Mizukoshi, Makoto Takano, Koichi Mizuno, Hisao Matsuda, Yoshihiro J. Akashi
Meeting Abstract
Cardiac & Cardiovascular Systems
Shunichi Doi, Hayato Wakabayashi, Yukio Sato, Norio Suzuki, Shingo Kuwata, Masaki Izumo, Yuki Ishibashi, Yasuhiro Tanabe, Yoshihiro John Akashi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)