Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

(2017) Congrong Niu et al.   PLoS One

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

(2016) Jie Wang et al.   JOURNAL OF HEPATOLOGY

Mechanisms of HBV-induced hepatocellular carcinoma

(2016) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx

(2016) Tianyu Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

(2016) Christopher M. Murphy et al.   Cell Reports

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

(2015) A. Jacome et al.   EMBO JOURNAL

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

The Smc5/6 Complex Is an ATP-Dependent Intermolecular DNA Linker

(2015) Takaharu Kanno et al.   Cell Reports

The maintenance of chromosome structure: positioning and functioning of SMC complexes

(2014) Kristian Jeppsson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

(2014) Kristian Jeppsson et al.   PLoS Genetics

Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity

(2014) Florian Full et al.   PLoS Pathogens

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription

(2013) S. Benhenda et al.   JOURNAL OF VIROLOGY

Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells

(2013) Lina Marcela Gallego-Paez et al.   MOLECULAR BIOLOGY OF THE CELL

New Therapeutic Targets and Drugs for the Treatment of Chronic Hepatitis B

(2013) Simon Fletcher et al.   SEMINARS IN LIVER DISEASE

Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates

(2012) Pieter C. van Breugel et al.   HEPATOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication

(2012) Amanda J. Hodgson et al.   VIROLOGY

The Smc complexes in DNA damage response

(2012) Nan Wu et al.   Cell and Bioscience

Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100

(2011) M. Adler et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

(2011) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Hepatitis B therapy

(2011) Hellan Kwon et al.   Nature Reviews Gastroenterology & Hepatology

Protein X of Hepatitis B Virus: Origin and Structure Similarity with the Central Domain of DNA Glycosylase

(2011) Formijn J. van Hemert et al.   PLoS One

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

(2010) M. Tsuge et al.   JOURNAL OF GENERAL VIROLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

The Yin and Yang of the MMS21–SMC5/6 SUMO ligase complex in homologous recombination

(2009) Patrick Ryan Potts   DNA REPAIR

The replication cycle of hepatitis B virus

(2009) Stephan Urban et al.   JOURNAL OF HEPATOLOGY

A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery

(2009) Ti Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1

(2008) Silvia Martin-Lluesma et al.   HEPATOLOGY