Journal
VIRUSES-BASEL
Volume 9, Issue 4, Pages -Publisher
MDPI AG
DOI: 10.3390/v9040085
Keywords
human papillomavirus; squamo-columnar junctions; (pre) neoplastic lesions
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Funding
- Belgian Fund for Medical Scientific Research (FNRS/Televie)
- Centre Anti-Cancereux pres l'Universite de Liege
- Fonds Leon Fredericq
- European Commission
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Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre) cancers. The present review summarizes the current knowledge on junctional cells, discusses their high vulnerability to HPV infection, and stresses the potential clinical/translational value of the novel dualistic model of HPV-related carcinogenesis.
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