Article
Medicine, General & Internal
Xingzhong Gu, Zhihong Shi, Shuai Liu, Yalin Guan, Hui Lu, Ying Zhang, Meilin Zhang, Shuling Liu, Wei Yue, Hao Wu, Xiaodan Wang, Yajing Zhang, Yong Ji
Summary: The study found a higher incidence of dementia in rural China than previously reported, with rates increasing with age and AD being the most common type of dementia. Poor education was associated with increased risk of VaD and AD, while engagement in social activities was identified as an independent protective factor for VaD.
Review
Clinical Neurology
Neal Weisbrod
Summary: Primary palliative care is essential for patients with serious illnesses like dementia. It involves effective communication, counseling, and referral when appropriate. The COVID-19 pandemic adds extra challenges, and clinicians must prioritize patient autonomy while ensuring informed decision making. Pain management and caregiver support are also important aspects of comprehensive care. Palliative care specialists can provide additional assistance in complex cases or when initial management strategies are insufficient.
Article
Geriatrics & Gerontology
Andreia Mascarelo, Ana Luisa Sant'Anna Alves, Siomara Regina Hahn, Marlene Doring, Marilene Rodrigues Portella
Summary: This study investigates the incidence and risk factors for polypharmacy among elderly people assisted by primary health care over an 11-year period in a small municipality in Brazil. The results show a high incidence of polypharmacy, and having more health problems is identified as a risk factor for polypharmacy.
Article
Geriatrics & Gerontology
Felix Bermejo-Pareja, Agustin Gomez de la Camara, Teodoro del Ser, Israel Contador, Sara Llamas-Velasco, Jesus Maria Lopez-Arrieta, Cristina Martin-Arriscado, Jesus Hernandez-Gallego, Saturio Vega, Julian Benito-Leon
Summary: The health status and self-perceived health are found to be associated with dementia and Alzheimer's disease, with physical activity being a protective factor.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Neurosciences
Miia Rahja, Tracy Air, Susannah Ahern, Stephanie A. Ward, Gillian E. Caughey, Janet K. Sluggett, Monica Cations, Xiaoping Lin, Kasey Wallis, Maria Crotty, Maria C. Inacio
Summary: This study aimed to evaluate the incidence of primary and secondary care clinical quality indicators (CQIs) for Australians with dementia using government subsidized aged care. The results showed an increase in incidence of all CQIs except for medication reviews. Being female, older, having fewer comorbidities, and living outside a major city were associated with lower likelihood of using the services.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Changzheng Yuan, Hui Chen, Yamin Wang, Julie A. Schneider, Walter C. Willett, Martha Clare Morris
Summary: This study found a protective relationship between long-term intake of total and individual dietary carotenoids and lower risk of cognitive decline. Results showed that higher intake of total carotenoids, particularly lutein/zeaxanthin, was significantly associated with lower hazard of AD. Examining the association of individual carotenoids with AD-related neuropathology revealed some components with inverse relationships.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Jung Eun Yoo, Youn Huh, Sang-Hyun Park, Kyungdo Han, Hye Soon Park, Kyung Hwan Cho, Jin-Soo Ahn, Sang Ho Jun, Ga Eun Nam
Summary: Periodontal disease, dental caries, and a high number of missing teeth are associated with an increased risk of dementia, while professional dental cleaning and frequent tooth brushing are associated with a decreased risk.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Chiara Celine Bruck, Frank J. Wolters, M. Arfan Ikram, Inge M. C. M. de Kok
Summary: Accurate projections of future dementia burden are important for healthcare systems and policymakers. Using a dementia microsimulation model, we found that changes in age-specific dementia incidence have a significant impact on the future burden of dementia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Rebecca F. Gottesman, Sudha Seshadri
Summary: This article summarizes the relationship between traditional cardiovascular risk factors and stroke, while also exploring their impact on brain health. It emphasizes the importance of genes and biomarkers associated with Alzheimer's disease, as well as the influence of social determinants of health on brain health outcomes.
Article
Medicine, General & Internal
Catharine Montgomery, Christine Schoetensack, Pooja Saini, Lynn Owens, Nadja Van Ginneken, Melissa Rice, Ryan Young, Andrew Jones
Summary: Liverpool has a high prevalence of alcohol use disorders (AUDs) compared with the rest of the UK. This study analyzed electronic health records over a 5-year period to identify changes in AUD incidence and prevalence in primary care. The findings showed a decrease in diagnoses over time and lower prescription rates for pharmacotherapy, especially in deprived areas. Overall, the identification and management of AUDs in primary care in Liverpool are suboptimal. Rating: 8/10.
Article
Medical Laboratory Technology
Jesper Qvist Thomassen, Janne S. Tolstrup, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: The study found that low and high plasma magnesium concentrations were associated with high risk of vascular-related non-Alzheimer dementia, with the lowest risk observed at a concentration of 2.07mg/dL. No association was observed for Alzheimer dementia. Mediation analysis suggested that diabetes may be in the causal pathway between low plasma magnesium concentrations and high risk of non-Alzheimer dementia.
CLINICAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Flavia Mayer, Giulia Remoli, Ilaria Bacigalupo, Ilaria Palazzesi, Paola Piscopo, Guido Bellomo, Marco Canevelli, Massimo Corbo, Nicola Vanacore, Eleonora Lacorte
Summary: Population ageing is a global social phenomenon where the risk of dementia may be changing in certain countries and areas. This systematic review examined recent observations of a possible decrease in dementia frequency in some Western countries between 1977 and 2014. The studies included had heterogeneity in clinical criteria and methodological quality.
Article
Primary Health Care
Anh N. Q. Pham, Cliff Lindeman, Don Voaklander, Adrian Wagg, Neil Drummond
Summary: This study examined the impact of risk factors on dementia onset in older adults in Canadian primary care settings. The results showed that age, history of depression, and certain socio-demographic and health factors were associated with an increased risk of dementia. However, sex, hypertension, obesity, dyslipidemia, and the use of antihypertensive medications and statins were not associated with dementia risk.
Review
Medicine, General & Internal
J. L. Liss, S. Seleri Assuncao, J. Cummings, A. Atri, D. S. Geldmacher, S. F. Candela, D. P. Devanand, H. M. Fillit, J. Susman, J. Mintzer, T. Bittner, S. A. Brunton, D. R. Kerwin, W. C. Jackson, G. W. Small, G. T. Grossberg, C. K. Clevenger, V. Cotter, R. Stefanacci, A. Wise-Brown, M. N. Sabbagh
Summary: Timely diagnosis and collaboration between primary care clinicians and specialists are crucial in adapting to new treatment paradigms and disease-modifying therapies in Alzheimer's disease care.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Namki Hong, Kyoung Jin Kim, Min Heui Yu, Seong Ho Jeong, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
Summary: This study examined the risk of dementia in patients with primary aldosteronism (PA) compared to patients with essential hypertension (EH). The findings revealed that treated PA patients were more likely to develop all-cause dementia compared to EH patients. Among PA patients, those using mineralocorticoid receptor antagonists (MRA) had a higher risk, especially for vascular dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Fred B. Ketchum, Jessica Monsees, Alice J. Kim, Tim Schmachtenberg, Amy Kind, Manish Shah, Wolfgang Hoffmann, Jochen Rene Thyrian, Andrea Gilmore-Bykovskyi
Summary: The objective of this study is to identify barriers and facilitators to the use of formal dementia services among underserved and minority groups in the United States and Germany. Through qualitative interviews with caregivers, it was found that limited knowledge, challenges in interacting with healthcare systems, and the alignment of formal services with cultural or ethnic/racial identity were important factors influencing the utilization of dementia care services.
AGING & MENTAL HEALTH
(2023)
Article
Environmental Sciences
Maria Isabel Cardona, Marina Weissenborn, Isabel Zoellinger, Eric Sven Kroeber, Alexander Bauer, Melanie Luppa, Alexander Pabst, David Czock, Hans-Helmut Koenig, Birgitt Wiese, Jochen Gensichen, Thomas Frese, Hanna Kaduszkiewicz, Wolfgang Hoffmann, Steffi G. Riedel-Heller, Jochen Rene Thyrian
Summary: This study used baseline data to describe physical activity engagement among community-dwelling Germans aged 60-77 years old with an increased risk of dementia and multimorbidity. Self-efficacy and BMI were identified as potential determinants of physical activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Katja Seidel, Tina Quasdorf, Julia Haberstroh, Jochen Rene Thyrian
Summary: Dementia is a major cause of disability and dependency in older people worldwide, requiring innovative care models. This study aims to investigate the influencing factors and critical pathways for implementing DCM standards in the existing primary care structures in the German region. The study found that insufficient involvement of relevant stakeholders and comprehensive consideration of patient needs through dementia care managers are the main barriers and facilitators for DCM implementation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Gerontology
Jessica Monsees, Tim Schmachtenberg, Jochen Rene Thyrian
Summary: Nearly 12 million elderly people of migrant origin live in Europe, and around 500,000 of them are estimated to have dementia. Due to cultural differences, people of migrant origin with dementia face additional challenges, highlighting the need for intercultural care. This study provides a comprehensive summary of current topics in intercultural care through a systematic literature analysis.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2022)
Review
Geriatrics & Gerontology
Clarissa Giebel, Katarzyna M. Lion, Klara Lorenz-Dant, Aida Suarez-Gonzalez, Catherine Talbot, Emily Wharton, Jacqueline Cannon, Hilary Tetlow, Jochen Rene Thyrian
Summary: This systematic review examines the impact of the COVID-19 pandemic on people with dementia living in the community or in residential care. The findings indicate that the pandemic has had negative effects on the cognition, physical functioning, and behavior of people with dementia, as well as limited access to care and poorer mental and social health.
AGING & MENTAL HEALTH
(2023)
Review
Geriatrics & Gerontology
Clarissa Giebel, Catherine V. Talbot, Emily Wharton, Klara Lorenz-Dant, Aida Suarez-Gonzalez, Jacqueline Cannon, Hilary Tetlow, Katarzyna M. Lion, Jochen Rene Thyrian
Summary: This study aimed to comprehensively evaluate the early impacts of the COVID-19 pandemic on unpaid dementia carers worldwide. The findings indicated that the pandemic had negative effects on the caregiving tasks, burden, and well-being of unpaid dementia carers. Policy initiatives should focus on providing better mental health support and formal care services for unpaid carers and their relatives with dementia, and further research is needed to explore the long-term implications of carer needs in light of care home restrictions and care delivery.
AGING & MENTAL HEALTH
(2023)
Editorial Material
Geriatrics & Gerontology
Jochen Rene Thyrian
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2022)
Article
Geriatrics & Gerontology
Jan Dreyer, Johannes Michael Bergmann, Kerstin Koehler, Iris Hochgraeber, Christiane Pinkert, Martina Roes, Jochen Rene Thyrian, Henrik Wiegelmann, Bernhard Holle
Summary: This study analyzed 320 care arrangements for persons with dementia and identified the underlying structures and types of these arrangements. The results contribute to a better understanding of informal dementia home care and can guide the development of tailored support for persons with dementia and their families.
Article
Medicine, General & Internal
Flora Wendel, Alexander Bauer, Iris Blotenberg, Christian Brettschneider, Maresa Buchholz, David Czock, Juliane Doehring, Catharina Escales, Thomas Frese, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut Koenig, Margrit Loebner, Melanie Luppa, Rosemarie Schwenker, Jochen Rene Thyrian, Marina Weissenborn, Birgitt Wiese, Isabel Zollinger, Steffi G. Riedel-Heller, Jochen Gensichen
Summary: This study describes the associations between social network, social participation, and depressive symptoms in older individuals at risk for dementia in Germany. The findings suggest that depressive symptoms are associated with smaller social networks and less social participation. Sufficient non-family contacts and weekly social activities play an important role in maintaining mental health among elderly primary care patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Roaa Zayed Atef, Bernhard Michalowsky, Anika Raedke, Moritz Platen, Wiebke Mohr, Franka Muehlichen, Jochen Rene Thyrian, Wolfgang Hoffmann
Summary: Hearing loss is common in people with dementia and can lead to social isolation and depression. This study suggests that the use of hearing aids may be associated with improvements in cognitive function, depression, and health-related quality of life in dementia patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Emrah Duezel, Jochen Rene Thyrian
Summary: It is important to combine treatment and preventive measures for Alzheimer's disease to maintain cognitive functions as long as possible. However, there are challenges in developing and researching treatment concepts. The use of mobile everyday-life digital technologies can help address these challenges by coordinating prevention efforts and focusing on cognitive health and safety. Relevant digital technologies include mobile apps for recording cognitive functions, coaching lifestyle changes, reducing treatment risks, and improving health competence. These medical products are at different stages of development.
Article
Clinical Neurology
Jochen Rene Thyrian
Summary: Background: Aging healthily and prevention of diseases are national health targets, and there is compelling evidence on modifiable risk factors suitable for preventive measures. Objective: This article defines terms, presents the roots of prevention in laws, strategies, and guidelines, and outlines the risk factors for dementia and effective preventive measures. Material and methods: The available evidence on risk factors, health behavior, and preventive measures is analyzed, and a multimodal intervention and the impact of motivation on behavior change are discussed.
Article
Public, Environmental & Occupational Health
Felix G. Wittmann, Andrea Zuelke, Alexander Pabst, Melanie Luppa, Jochen Rene Thyrian, Anika Kaestner, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Juliane Doehring, Catharina Escales, Jochen Gensichen, Isabel Zoellinger, Robert Philipp Kosilek, Birgitt Wiese, Anke Oey, Hans-Helmut Koenig, Christian Brettschneider, Thomas Frese, Steffi G. G. Riedel-Heller
Summary: This study analyzed the impact of perceived restriction due to government measures on depressive symptoms in older adults at increased risk for dementia in Germany. The results showed that feeling restricted due to COVID-19 measures was associated with higher levels of depressive symptoms, and this association was mediated by perceived stress.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Maria Isabel Cardona, Jessica Monsees, Tim Schmachtenberg, Anna Gruenewald, Jochen Rene Thyrian
Summary: Despite the health benefits of physical activity for people with dementia, their engagement remains low. Previous research has not used implementation science frameworks to explore the barriers and facilitators of physical activity initiatives in this population. Therefore, a more comprehensive understanding of these mediating factors is needed.
Article
Medicine, General & Internal
Isabel Zoellinger, Alexander Bauer, Iris Blotenberg, Christian Brettschneider, Maresa Buchholz, David Czock, Juliane Doehring, Catharina Escales, Thomas Fankhaenel, Thomas Frese, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut Koenig, Melanie Luppa, Anke Oey, Alexander Pabst, Linda Sanftenberg, Jochen Rene Thyrian, Julian Weiss, Flora Wendel, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen, Piotr Galecki
Summary: In order to develop effective dementia prevention strategies, it is important to understand the risk factors, associated factors, and early signs of dementia. This study found that depressive symptoms, sleeping problems, and higher education levels are significantly associated with subjective cognitive decline (SCD), which is an early form of dementia.
JOURNAL OF CLINICAL MEDICINE
(2023)
