Article
Environmental Sciences
Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang Lu
Summary: Exposure to Sulfometuron methyl (SM) led to toxicity in zebrafish early developmental stages, affecting development, immune system, locomotor behavior, oxidative stress, and cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla
Summary: This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish larvae, finding that approximately half of the chemicals showed no gross developmental toxicity at the highest concentration tested. Some chemicals were toxic only at higher concentrations, while 11 chemicals caused behavioral effects, with four altering behavior in the absence of developmental toxicity.
Article
Cell Biology
Marta Marszalek-Grabska, Kinga Gawel, Nataliia Kosheva, Tomasz Kocki, Waldemar A. Turski
Summary: Proper nutrition and supplementation during pregnancy and breastfeeding are crucial for offspring development. The study found that incubation with Kynurenine (KYN) during early zebrafish development affected their behavior. Additionally, injecting KYN during early pregnancy resulted in subtle differences in the neurobehavioral development of adult offspring. Further research is needed to understand the underlying mechanisms of these changes.
Article
Environmental Sciences
Junho Park, Taeyeon Hong, Garam An, Hahyun Park, Gwonhwa Song, Whasun Lim
Summary: Various types of fungicides, including triadimenol, are used to protect crops from fungal diseases. However, the developmental toxicity of triadimenol on zebrafish is not well understood. In this study, we used the zebrafish animal model to investigate the effects of triadimenol. Triadimenol caused morphological abnormalities, increased reactive oxygen species production, inflammation-related gene expression, and apoptosis in zebrafish, especially in the heart region. It also disrupted the PI3K and MAPK signaling pathways, leading to malformation of the heart and vascular structures. These findings provide insights into the mechanisms underlying triadimenol toxicity in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biology
William Tyler Frantz, Sharanya Iyengar, James Neiswender, Alyssa Cousineau, Rene Maehr, Craig J. Ceol
Summary: Tissue-resident stem and progenitor cells play important roles in maintaining organ homeostasis and repairing damage. However, the mechanisms governing their renewal and differentiation are not well understood, especially in non-hematopoietic tissues. In this study, melanocyte progenitors in adult zebrafish skin were identified and analyzed to uncover the mechanisms underlying melanocyte regeneration. It was revealed that KIT signaling through the RAS/MAPK pathway regulates direct differentiation and asymmetric division of melanocyte progenitors.
Article
Marine & Freshwater Biology
Dong-Dong Ma, Wen-Jun Shi, Si-Ying Li, Jin-Ge Zhang, Zhi-Jie Lu, Xiao-Bing Long, Xin Liu, Chu-Shu Huang, Guang-Guo Ying
Summary: This study found that EPH and COC had noticeable developmental neurotoxicity in early-stage zebrafish at environmentally relevant concentrations, causing effects such as irregular heart rate, cell apoptosis, abnormal behavior, and altered neurotransmitter levels.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Zhengkang Su, Fengqing Qin, Hai Zhang, Zhengwei Huang, Kaiyu Guan, Miaomiao Zheng, Ziru Dai, Weihong Song, Xi Li
Summary: This study evaluated the developmental toxicity of Safinamide in zebrafish embryos using various concentrations of the drug. The results showed that higher concentrations (30 μM) of Safinamide caused a decrease in hatching rate and an increase in malformation and mortality in zebrafish larvae. Lower exposure (10 μM) to Safinamide resulted in increased body length and hyperactivity-like behaviors in the zebrafish larvae. The study also identified disturbances in physiological processes such as neuroactive ligand-receptor interaction signaling pathway. The findings suggest that Safinamide may cause developmental defects and toxicity during early development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Saima Rehman, Adnan H. Gora, Shubham Varshney, Jorge Dias, Pal A. Olsvik, Jorge M. O. Fernandes, Sylvia Brugman, Viswanath Kiron
Summary: The study reveals the effects of soybean meal-induced inflammation model on the behavior of zebrafish, including reduced locomotor activity, induced developmental defects, and increased oxygen demand. Furthermore, beta-glucan can counteract the negative effects of a soybean diet on behavior and phenotype.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Siyu Xia, Xinhong Zhu, Yuepei Yan, Tao Zhang, Guoliang Chen, Daoxi Lei, Guixue Wang
Summary: This study revealed the neurotoxic and developmental toxicity of antimony on zebrafish embryos, primarily affecting neurotransmitter systems and oxidative stress, thereby altering behavior. The findings advance the understanding of antimony-induced neurotoxicity, environmental issues, and health hazards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Environmental Sciences
Huiqi Li, Yinai Liu, Qianqian Chen, Libo Jin, Renyi Peng
Summary: With the worsening of environmental pollution, the study of aquatic ecotoxicology has become popular. Aquatic organisms such as large fleas, toads, and zebrafish have been developed and used as model organisms due to their small size, easy reproduction, short life cycle, low maintenance cost, and ability to evaluate the toxicity of environmental pollutants using various methods. This review focuses on the use of zebrafish in aquatic ecotoxicology, including its developmental toxicity, biomarkers, genomics, and phenotype analysis, providing a valuable reference for researchers in selecting model animals for their studies.
Article
Multidisciplinary Sciences
Aditya Ghoshal, Anuradha Bhat
Summary: The research shows that male zebrafish prefer to visit shoals composed of 8 females, and exhibit a preference for areas with high and moderate vegetation regardless of the number of females present. This study indicates that preference for group size can change due to the interaction of multiple factors, and highlights the role of aquatic flora in shaping shoaling preferences in zebrafish.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Xiaoxi Yang, Jiefeng Liang, Qi Wu, Min Li, Wanyu Shan, Li Zeng, Linlin Yao, Yong Liang, Chang Wang, Jie Gao, Yingying Guo, Yaquan Liu, Rui Liu, Qian Luo, Qunfang Zhou, Guangbo Qu, Guibin Jiang
Summary: The study demonstrates that few-layered BP can have developmental toxicity towards zebrafish, leading to heart deformities and circulatory system failure. Analysis using transgenic zebrafish larvae shows cardiovascular defects after BP exposure, and transcriptomic analysis indicates disruption in genes associated with various processes and pathways even at lower concentrations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Edward J. Perkins, Kimberly T. To, Lindsey St Mary, Charles H. Laber, Anthony J. Bednar, Lisa Truong, Robyn L. Tanguay, Natalia Garcia-Reyero
Summary: Dyes Disperse Blue 14, Disperse Red 9, Solvent Red 169, and Solvent Yellow 33 have been found to adversely affect zebrafish embryos, with Disperse Blue 14 and Solvent Yellow 33 having the most significant impact on development and behavior.
Article
Engineering, Environmental
Lisa Truong, Yvonne Rericha, Preethi Thunga, Skylar Marvel, Dylan Wallis, Michael T. Simonich, Jennifer A. Field, Dunping Cao, David M. Reif, Robyn L. Tanguay
Summary: This study conducted an extensive in vivo developmental toxicity screen on 139 PFAS, and found that 49 of them exhibited bioactivity in at least one assay. Perfluorooctanesulfonamide (FOSA) was the only structure that showed bioactivity in all assays. The study also revealed a correlation between low volatility of PFAS and developmental toxicity, while no association was found between bioactivity and other physicochemical parameters.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Janiel K. Ahkin Chin Tai, Katharine A. Horzmann, Thomas L. Jenkins, Isabelle N. Akoro, Sydney Stradtman, Uma K. Aryal, Jennifer L. Freeman
Summary: Atrazine, a commonly used herbicide, has been found to contaminate water sources and affect the morphology and behavior of progeny. This study used zebrafish as a model and found that embryonic parental exposure to atrazine resulted in altered cellular pathways, leading to perturbations in craniofacial development and increased locomotor activity in offspring.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Developmental Biology
Matthew Hur, Charlotte A. Gistelinck, Philippe Huber, Jane Lee, Marjorie H. Thompson, Adrian T. Monstad-Rios, Claire J. Watson, Sarah K. McMenamin, Andy Willaert, David M. Parichy, Paul Coucke, Ronald Y. Kwon
Article
Anatomy & Morphology
Stephanie Keer, Karly Cohen, Catherine May, Yinan Hu, Sarah McMenamin, Luz Patricia Hernandez
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Anatomy & Morphology
Yinan Hu, Angela Mauri, Joan Donahue, Rajendra Singh, Benjamin Acosta, Sarah McMenamin
DEVELOPMENTAL DYNAMICS
(2019)
Article
Evolutionary Biology
Demi Galindo, Elly Sweet, Zoey DeLeon, Mitchel Wagner, Adrian DeLeon, Casey Carter, Sarah K. McMenamin, W. James Cooper
EVOLUTION & DEVELOPMENT
(2019)
Article
Evolutionary Biology
W. James Cooper, Rachel VanHall, Elly Sweet, Holly Milewski, Zoey DeLeon, Amy Verderber, Adrian DeLeon, Demi Galindo, Orissa Lazono
EVOLUTION & DEVELOPMENT
(2020)
Article
Biology
Jennifer Bagwell, James Norman, Kathryn Ellis, Brianna Peskin, James Hwang, Xiaoyan Ge, Stacy Nguyen, Sarah K. McMenamin, Didier Y. R. Stainier, Michel Bagnat
Editorial Material
Ecology
Sarah McMenamin, Fedor Shkil, Takashi Koyama
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Evolutionary Biology
Stephanie Keer, Joshua D. Storch, Stacy Nguyen, Mia Prado, Rajendra Singh, Luz Patricia Hernandez, Sarah K. McMenamin
Summary: Thyroid hormone plays a crucial role in shaping the craniofacial skeleton, particularly during larval development. Excess or deficiency of this hormone can lead to abnormal skeletal morphologies with potential functional consequences. Skeletal features with functional importance show high sensitivity to thyroid hormone.
EVOLUTION & DEVELOPMENT
(2022)
Article
Physiology
Stacy V. Nguyen, Dominic Lanni, Yongqi Xu, James S. Michaelson, Sarah K. McMenamin
Summary: Zebrafish is a valuable model for studying skeletal development and disorders, and 3D technologies can provide detailed insights into the process. This study generated a high-resolution skeletal reference dataset for zebrafish and analyzed the changes in density and volume during growth. The findings provide quantitative and qualitative assessments of skeletal changes throughout development.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Melody Harper, Yinan Hu, Joan Donahue, Benjamin Acosta, Flora Dievenich Braes, Stacy Nguyen, Jenny Zeng, Julianna Barbaro, Hyungwoo Lee, Hoa Bui, Sarah K. McMenamin
Summary: Thyroid hormone regulates proximodistal patterning of the caudal fin rays in zebrafish, coordinating ray bifurcations and segment shortening. This regulation is independent of fin size and is conserved across species. Proximodistal morphology can be modified relative to size through modulation of thyroid hormone metabolism or other hormone-independent pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
M. A. Fath, S. V. Nguyen, J. Donahue, S. K. McMenamin, E. D. Tytell
Summary: This study used micro-computed tomography to determine the locations of the center of mass (COM) and center of buoyancy (COB) in bluegill sunfish. The findings showed a small but significant difference between the locations of COM and COB, which can be influenced by the shape and centroid location of the swim bladder. The swim bladder volume, however, did not show any correlation with the distance between COM and COB.
INTEGRATIVE ORGANISMAL BIOLOGY
(2023)
Article
Biology
M. R. Conith, D. Ringo, A. J. Conith, A. Deleon, M. Wagner, S. McMenamin, C. Cason, W. J. Cooper
Summary: By linking anatomical structure to mechanical performance, this study explores how selection shapes morphology in fishes of the subfamily Danioninae. The researchers found that differences in jaw protrusion are strongly associated with differences in feeding strategies among different clades of Danioninae. The shape of the premaxillary bone plays a major role in protrusion ability, and its morphology is consistent with the feeding strategies employed by each lineage. The study also identifies an important evolutionary module that has contributed to the trophic mechanics within the Danioninae.
INTEGRATIVE ORGANISMAL BIOLOGY
(2022)