Differential regulation of intestinal efflux transporters by pregnancy in mice

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype

(2012) Shadi Abu-Hayyeh et al.   HEPATOLOGY

Repression of Hepatobiliary Transporters and Differential Regulation of Classic and Alternative Bile Acid Pathways in Mice During Pregnancy

(2012) Lauren M. Aleksunes et al.   TOXICOLOGICAL SCIENCES

Rifampicin-Independent Interactions between the Pregnane X Receptor Ligand Binding Domain and Peptide Fragments of Coactivator and Corepressor Proteins

(2011) Punya Navaratnarajah et al.   BIOCHEMISTRY

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis

(2011) Sigurd Lax et al.   INTERNATIONAL JOURNAL OF CANCER

A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor

(2011) Guodong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes

(2010) Hyunyoung Jeong   Expert Opinion on Drug Metabolism & Toxicology

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function

(2010) Alexandra Milona et al.   HEPATOLOGY

Inhibition of Na+-Taurocholate Co-transporting Polypeptide-mediated Bile Acid Transport by Cholestatic Sulfated Progesterone Metabolites

(2010) Shadi Abu-Hayyeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells

(2010) Bhavani Prasad Kota et al.   PHARMACOLOGICAL RESEARCH

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

(2009) Salvatore Modica et al.   GASTROENTEROLOGY

Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course

(2008) H. Zhang et al.   MOLECULAR PHARMACOLOGY

The organic solute transporter  - , Ost -Ost , is essential for intestinal bile acid transport and homeostasis

(2008) A. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

(2007) P Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY