Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987-2013

Adult Utilization of Psychiatric Drugs and Differences by Sex, Age, and Race

(2017) Thomas J. Moore et al.   JAMA Internal Medicine

The Nature of Placebo Response in Clinical Studies of Major Depressive Disorder

(2015) George I. Papakostas et al.   JOURNAL OF CLINICAL PSYCHIATRY

A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of 2 Doses of Vortioxetine in Adults With Major Depressive Disorder

(2015) Atul R. Mahableshwarkar et al.   JOURNAL OF CLINICAL PSYCHIATRY

Factors contributing to the increasing placebo response in antidepressant trials

(2015) Siegfried Kasper et al.   World Psychiatry

Antidepressant or antidepressant plus placebo effect?

(2015) Stuart A. Montgomery   World Psychiatry

Antidepressants: misnamed and misrepresented

(2015) Joanna Moncrieff   World Psychiatry

Antidepressants versus placebo in major depression: an overview

(2015) Arif Khan et al.   World Psychiatry

Placebo for depression: we need to improve the quality of scientific information but also reject too simplistic approaches or ideological nihilism

(2014) Andrea Cipriani et al.   BMC Medicine

Impact of patient selection and study characteristics on signal detection in placebo-controlled trials with antidepressants

(2014) Michele Mancini et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Magnitude of placebo response and response variance in antidepressant clinical trials using structured, taped and appraised rater interviews compared to traditional rating interviews

(2014) Arif Khan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Magnitude of change with antidepressants and placebo in antidepressant clinical trials using structured, taped and appraised rater interviews (SIGMA-RAPS) compared to trials using traditional semi-structured interviews

(2014) Arif Khan et al.   PSYCHOPHARMACOLOGY

A Model of Placebo Response in Antidepressant Clinical Trials

(2013) Bret R. Rutherford et al.   AMERICAN JOURNAL OF PSYCHIATRY

Which placebo to cure depression? A thought-provoking network meta-analysis

(2013) Florian Naudet et al.   BMC Medicine

Obtained effect size as a function of sample size in approved antidepressants

(2012) Michael Gibertini et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Exploratory Analyses of Efficacy Data From Major Depressive Disorder Trials Submitted to the US Food and Drug Administration in Support of New Drug Applications

(2011) Ni A. Khin et al.   JOURNAL OF CLINICAL PSYCHIATRY

Randomized, Placebo-Controlled Trials of Antidepressants for Acute Major Depression: Thirty-Year Meta-Analytic Review

(2011) Juan Undurraga et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data

(2010) Konstantinos N. Fountoulakis et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant Drug Effects and Depression Severity

(2010) Jay C. Fournier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Does Inclusion of a Placebo Arm Influence Response to Active Antidepressant Treatment in Randomized Controlled Trials?

(2010) Mark Sinyor et al.   JOURNAL OF CLINICAL PSYCHIATRY

Meta-analysis of the placebo response in antidepressant trials

(2009) Winfried Rief et al.   JOURNAL OF AFFECTIVE DISORDERS

Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD

(2008) George I. Papakostas et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Publication of Clinical Trials Supporting Successful New Drug Applications: A Literature Analysis

(2008) Kirby Lee et al.   PLOS MEDICINE

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE

Is bigger better for depression trials?

(2007) Kenneth S. Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH