Article
Oncology
Yiwen Qiu, Yi Yang, Tao Wang, Shu Shen, Wentao Wang
Summary: This study investigated the impact of microscopic portal vein invasion (MPVI) on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE). The results showed that PA-TACE had better recurrence-free survival (RFS) and overall survival (OS) outcomes in patients without MPVI. However, for patients with MPVI, PA-TACE did not significantly improve RFS or OS outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Haoyu Hu, Shuo Qi, Silue Zeng, Peng Zhang, Linyun He, Sai Wen, Ning Zeng, Jian Yang, Weiqi Zhang, Wen Zhu, Nan Xiang, Chihua Fang
Summary: The study established a predictive model to forecast the occurrence of microvascular invasion in HCC patients, and compared the efficacy of anatomic resection and non-anatomic resection for hepatocellular carcinoma. The predictive model was found to be convenient and accurate, highlighting the importance of performing anatomic resection in patients with high risk of MVI or low risk of MVI with larger tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fang-Ying Kuo, Yueh-Wei Liu, Chih-Che Lin, Chee-Chien Yong, Chih-Chi Wang, Chao-Long Chen, Yu-Fan Cheng, Jing-Houng Wang, Yi-Hao Yen
Summary: The study validated the simple classifications of microscopic vascular invasion (MVI), specifically microscopic portal vein invasion (MPVI) and microvessel invasion (MI). Among the patients studied, those in the MI-only group showed similar 5-year overall survival rates to those in the NVI group, while the MPVI group had significantly lower rates. Multivariate analysis confirmed that MPVI is independently associated with lower overall survival compared to NVI, making the MVI classifications clinically useful.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ding-Sen Huang, Ting-Ting Liu, Wei-Ting Lu, Chih-Chi Wang, Chih-Che Lin, Chee-Chen Yong, Kuang-Den Chen, Yueh-Wei Liu, Yuan-Hung Kuo, Yi-Hao Yen, Tsung-Hui Hu, Ming-Chao Tsai
Summary: This study compared the impact of portal vein and capsular vein MVI on HCC recurrence and overall survival. The results showed that both-MVI type is an independent risk factor for HCC recurrence, especially for extrahepatic recurrence.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Surgery
Incheon Kang, Mi Jang, Jae Geun Lee, Dai Hoon Han, Dong Jin Joo, Kyung Sik Kim, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Young Nyun Park, Gi Hong Choi
Summary: Subclassification of MiVI in HCC showed that MPVI was associated with more aggressive tumor characteristics and poorer survival compared to MI only. The original MiVI classification should be divided into MI and MPVI for better prognostic assessment.
Article
Surgery
Ahmed Shehta, Ahmed Farouk, Ahmed Nabieh Elghawalby, Mohamed Elshobary, Ahmed Aboelenin, Amgad Fouad, Mahmoud Abdelwahab Ali
Summary: The study evaluated the experience of liver resection for hepatocellular carcinoma patients with macroscopic portal vein invasion and found that patients with macroscopic PVI had lower overall survival rates and higher incidence of post-operative morbidities. However, there were no significant differences in terms of recurrence rate and disease-free survival rates between the two groups.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Brian Carr, Vito Guerra, Rossella Donghia, Volkan Ince, Sami Akbulut, Veysel Ersan, Sertac Usta, Burak Isik, Emine Samdanci, Sezai Yilmaz
Summary: Background factors like microscopic portal vein invasion (microPVI) and tumor multifocality are important prognostic factors in hepatocellular carcinoma (HCC). This study aimed to investigate the direct relationship between microPVI and multifocality, finding that microPVI had a stronger association with maximum tumor diameter (MTD) and worse survival outcomes in patients with larger HCCs. However, the number of tumor foci did not impact patient survival outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Junichi Shindoh, Yuta Kobayashi, Ryosuke Umino, Kazutaka Kojima, Satoshi Okubo, Masaji Hashimoto
Summary: Anatomic resection (AR) is oncologically advantageous for patients with primary solitary HCC, showing better recurrence-free survival, time-to-interventional failure, and overall survival compared to non-AR group. AR significantly decreases local recurrence and is correlated with smaller number and size of recurrent lesions, leading to better postprogression survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shin Hwang, Deok-Bog Moon, Ki-Hun Kim, Chul-Soo Ahn, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
Summary: This study evaluated the prognostic accuracy of the ADV score in patients with HCC and PVTT, and found that the ADV score is an integrated surrogate biomarker with high prognostic accuracy in predicting tumor recurrence and patient survival under stratification.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Clinical Neurology
Zhijie Pei, Jiaxing Wang, Shuwen Mu, Tianshun Feng, Meina Wang, Shentong Yu, Liangfeng Wei, Yi Fang, Shousen Wang
Summary: The study found that factors such as Knosp grade 3-4, a greater proportion of suprasellar tumor volume, and evidence of invasion of the cavernous sinus during surgery make it more difficult to completely remove giant pituitary adenomas.
FRONTIERS IN NEUROLOGY
(2022)
Article
Surgery
Yukiyasu Okamura, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Takeshi Aramaki, Katsuhiko Uesaka
Summary: The study found that high des-gamma-carboxy prothrombin concentration, large tumor size, and high aspartate aminotransferase concentration were significant predictors of MVI and/or MIM. The 5-year overall survival rates for patients with zero, one, two, and three risk factors were 97.4%, 73.5%, 71.5%, and 65.5% respectively, with the AR group having superior survival rates in patients with one or two risk factors compared to the non-AR group.
Article
Medicine, General & Internal
Jae Hyun Kwon, Jung-Woo Lee, Jong Woo Lee, Young Joo Lee
Summary: This study compared the survival outcomes and recurrence rates of anatomical resection (AR) versus non-anatomical resection (NAR) in hepatocellular carcinoma (HCC) according to tumor size. The results showed that AR reduced the risk of tumor recurrence and improved overall survival in patients with HCCs smaller than 5 cm, while AR and NAR showed comparable survival outcomes in HCCs larger than 5 cm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qizhen Huang, Kongying Lin, Zhipeng Lin, Hongbin Ji, Xiaoyu Zhou, Bin Wang, Yufeng Chen, Chuandong Sun, Shuguo Zheng, Jinhong Chen, Yifan Wang, Yanming Zhou, Weiping Zhou, Yongyi Zeng
Summary: This study evaluated the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) after R0 resection. The results showed that isolated MiBDI did not influence overall survival (OS), while the presence of both bile duct and vascular invasion (MiBDI+MVI+), microscopic vascular invasion alone (MiBDI-MVI+), and macroscopic bile duct invasion (MaBDI) were associated with worse OS.
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biophysics
Hui-Yan Li, Fang-Fei Yin, Xin-Yi Li, Wan-Nan Jia, Jia Ding, Li Zhang, Zhong-Hua Wang, Qin-Qin Hu, Jie-Liang Zuo, Hu-Liang Jia, Li-Hua Wang, Chun-Hai Fan, Hong-Zhou Gu, Jian Wu
Summary: In this study, an aptamer AP32 specific to SHh was obtained by SELEX technology and a novel aptamer-based assay was successfully developed. The method exhibited a broad detection range, high sensitivity, and could be used to predict early metastasis and poor prognosis in HCC, even in AFP-negative cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Gastroenterology & Hepatology
Kazuki Wakizaka, Hideki Yokoo, Toshiya Kamiyama, Masafumi Ohira, Koichi Kato, Yuki Fujii, Ko Sugiyama, Naoki Okada, Takanori Ohata, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Hirofumi Kamachi, Akinobu Taketomi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Surgery
Shingo Shimada, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Akihisa Nagatsu, Takanori Ohata, Hirofumi Kamachi, Akinobu Taketomi
WORLD JOURNAL OF SURGERY
(2019)
Article
Gastroenterology & Hepatology
Makoto Chuma, Hidenori Toyoda, Juntaro Matsuzaki, Yoshimasa Saito, Takashi Kumada, Toshifumi Tada, Yuji Kaneoka, Atsuyuki Maeda, Hideki Yokoo, Koji Ogawa, Toshiya Kamiyama, Akinobu Taketomi, Yoshihiro Matsuno, Keiichi Yazawa, Kazuhisa Takeda, Chikara Kunisaki, Katsuaki Ogushi, Satoshi Moriya, Koji Hara, Akito Nozaki, Masaaki Kondo, Hiroyuki Fukuda, Kazushi Numata, Katsuaki Tanaka, Shin Maeda, Naoya Sakamoto
HEPATOLOGY RESEARCH
(2019)
Article
Surgery
Shingo Shimada, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Kenji Wakayama, Akihisa Nagatsu, Tatsuhiko Kakisaka, Hirofumi Kamachi, Daisuke Abo, Yusuke Sakuhara, Akinobu Taketomi
Article
Gastroenterology & Hepatology
Kazuki Wakizaka, Hideki Yokoo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Masafumi Ohira, Michio Tani, Koichi Kato, Yuki Fujii, Ko Sugiyama, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Hirofumi Kamachi, Ryosuke Matsuoka, Akinobu Taketomi
HEPATOLOGY RESEARCH
(2020)
Article
Oncology
Hidenori Takahashi, Toshiya Kamiyama, Nozomi Hirane, Nozomi Kobayashi, Takeshi Aiyama, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Tatsuhiko Kakisaka, Moto Fukai, Hideki Yokoo, Hirofumi Kamachi, Shin-Ichiro Nishimura, Akinobu Taketomi
Article
Multidisciplinary Sciences
Takeshi Aiyama, Tatsuya Orimo, Hideki Yokoo, Takanori Ohata, Kanako C. Hatanaka, Yutaka Hatanaka, Moto Fukai, Toshiya Kamiyama, Akinobu Taketomi
Article
Oncology
Kazuki Wakizaka, Toshiya Kamiyama, Kenji Wakayama, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Hirofumi Kamachi, Hideki Yokoo, Moto Fukai, Nozomi Kobayashi, Tomoko Mitsuhashi, Akinobu Taketomi
Article
Gastroenterology & Hepatology
Hiroyoshi Iwata, Naoto Matsuno, Daisuke Ishii, Asuka Toriumi, Masahide Otani, Mizuho Ohara, Hiromichi Obara, Yuji Nishikawa, Hideki Yokoo
Summary: This study compared the use of University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution as machine perfusion solutions for marginal liver grafts. The results showed that histidine-tryptophan-ketoglutarate solution can decrease vascular resistance, reduce shear stress, and protect sinusoid epithelial cells in split-liver grafts.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Hiroyoshi Iwata, Hiromichi Obara, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa, Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Mizuho Ohara, Hideki Yokoo, Naoto Matsuno
Summary: This study investigated the benefits of using subnormothermic extracorporeal membrane oxygenation (ECMO) and hypothermic machine perfusion (HMP) in a porcine model of liver transplantation from donors after cardiac death (DCD). The results suggested that the combination of ECMO and HMP could improve the functional outcome of DCD liver grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Yuki Adachi, Hiroyuki Takahashi, Tomohiro Yamamoto, Masahiro Hagiwara, Koji Imai, Hideki Yokoo
Summary: This article described a rare case of right-sided ligamentum teres variation, in which the patient underwent laparoscopic hepatectomy. The article emphasized the importance of avoiding injury to the right hepatic vasculature during left lobectomy.
Review
Oncology
Yuki Adachi, Hideki Yokoo, Masahiro Hagiwara, Hiroyuki Takahashi, Hiroyoshi Iwata, Tomohiro Takeda, Tomohiro Yamamoto, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Naoto Matsuno
Summary: Lymphoepithelioma-like cholangiocarcinoma is a rare variant of primary liver tumor, which occurs more frequently in Asian women and is strongly associated with EBV and hepatitis viruses. This article describes a case of LEL-CC in a 76-year-old woman not associated with EBV or hepatitis virus.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Makoto Chuma, Hideki Yokoo, Atsushi Hiraoka, Kazuhiko Ueda, Takahiro Yokoyama, Kunihiko Tsuji, Noritomo Shimada, Haruki Uojima, Satoshi Kobayashi, Nobuhiro Hattori, Tomomi Okubo, Masanori Atsukawa, Toru Ishikawa, Koichi Takaguchi, Akemi Tsutsui, Hidenori Toyoda, Toshifumi Tada, Yoshinori Saito, Shunji Hirose, Takaaki Tanaka, Kazuhisa Takeda, Masako Otani, Zenjiro Sekikawa, Tsunamasa Watanabe, Hisashi Hidaka, Manabu Morimoto, Kazushi Numata, Tatehiro Kagawa, Michiie Sakamoto, Takashi Kumada, Shin Maeda
Summary: This study evaluated the utility of computed tomography attenuation value (CTav) in predicting tumor necrosis in hepatocellular carcinoma patients who achieved complete response after lenvatinib treatment. The results showed that a CTav threshold of 30.2 HU could identify post-lenvatinib necrosis, and an N30-CTav occupancy rate of >30.6% was a predictor of maintaining complete response.
Article
Oncology
Nobuki Ichikawa, Toshiya Kamiyama, Hideki Yokoo, Shigenori Homma, Yoshiaki Maeda, Toshiki Shinohara, Yosuke Tsuruga, Keizo Kazui, Hiroaki Iijima, Tadashi Yoshida, Akinobu Taketomi
MOLECULAR AND CLINICAL ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Takuya Sho, Goki Suda, Koji Ogawa, Megumi Kimura, Tomoe Shimazaki, Osamu Maehara, Taku Shigesawa, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Machiko Umemura, Naoki Kawagishi, Mitsuteru Natsuizaka, Masato Nakai, Kenichi Morikawa, Ken Furuya, Masaru Baba, Yoshiya Yamamoto, Tomoe Kobayashi, Takashi Meguro, Akiyoshi Saga, Takuto Miyagishima, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi, Naoya Sakamoto