Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 23, Issue 19, Pages 3418-3426Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i19.3418
Keywords
Pruritus; Cholestasis; Autotaxin; Opioid receptor antagonist
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Pruritus is a symptom found in patients with chronic liver diseases, especially cholestatic liver diseases such as primary biliary cholangitis. This symptom impairs patient quality of life by disturbing sleep and may lead to consideration of liver transplantation. Mechanisms implicated in pruritus have been associated with the peripheral and central nervous systems, leading to the development of various therapeutic options. Little evidence for the efficacy of most of these treatments is currently available, indicating a need for further investigations.
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