Article
Plant Sciences
Peng Zeng, Xiao-Ming Wang, Hong-Fei Su, Teng Zhang, Lin-Na Ning, Yan Shi, Shu-Sheng Yang, Li Lin, Qing Tian
Summary: The study confirmed the protective effects of DCQ on ICH, possibly through the inhibition of MAPK and activation of M2 microglia. These results are beneficial for the development of therapeutic targets for ICH.
Article
Plant Sciences
Xiaowen Liu, Lin Yuan, Yishuang Tang, Yue Wu, Jing Kong, Bingduo Zhou, Xiaosu Wang, Min Lin, Yading Li, Gaofan Xu, Yi Wang, Tingting Xu, Cong He, Shengquan Fang, Shengliang Zhu
Summary: The study aimed to explore the mechanism of Da-Cheng-Qi Decoction (DCQD) in treating Severe Acute Pancreatitis-Associated Acute Lung Injury (SAP-ALI), focusing on intestinal barrier function and intestinal lymphatic pathway. The results showed that DCQD improved SAP-ALI in rats by interfering with intestinal lymphatic pathway and reducing HMGB1-induced inflammatory response.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Xiang Qi, Yang Shimin, Wu Yu
Summary: The transnasal ileus tube is an effective treatment for malignant bowel obstruction, and compound Da-Cheng-Qi Decoction can enhance the therapeutic effect on MBO by promoting intestinal exhaust and defecation, improving the palliative treatment outcome.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Immunology
Frederick G. Hayden, Robert P. Lenk, Carol Epstein, Lih Lisa Kang
Summary: This study reveals the pharmacokinetics of oral favipiravir and its relationship to antiviral effects in influenza. Higher levels of favipiravir (>20ug/ml) are associated with better antiviral effects and faster alleviation of symptoms.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Integrative & Complementary Medicine
Zehua Zhou, Ying Chen, Wenmin Dong, Rui An, Kun Liang, Xinhong Wang
Summary: The study showed that DCQD could protect against cerulein-induced inflammation and reduce the secretion of pancreatic biochemical markers, potentially by mediating the activation of the JAK2/STAT3 signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Rui-Pei Yang, Da-Ke Cai, Yu-Xing Chen, Hai-Ning Gang, Mei Wei, De-Quan Zhu, Su-Mei Li, Jiu-Mei Yang, Si-Ni Luo, Xiao-Li Bi, Dong-Mei Sun
Summary: The study demonstrated that THCQ decoction has a significant protective effect against secondary brain injury induced by intracerebral hemorrhage in rats, potentially through the improvement of metabolic disorders in cerebral hemorrhage rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Luqman Vali, David R. Jenkins, Rakesh Vaja, Hussain Mulla
Summary: The study demonstrated that bedside Bayesian-guided personalised dosing of vancomycin in vascular surgery patients can increase the proportion of patients achieving target AUC(24) values and the percentage time in the target range.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Infectious Diseases
Cornelia B. Landersdorfer, Amanda Gwee, Roger L. Nation
Summary: Traditionally, ongoing i.v. antibiotic therapy has been believed to be superior to early i.v. to oral switch for severe infections. However, this belief may not be based on robust data and contemporary clinical studies. This review examines the rationale for an early switch and discusses barriers and perceptions related to this practice.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Transplantation
Mendy ter Avest, Romy N. Bouwmeester, Caroline Duineveld, Kioa L. Wijnsma, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, David M. Burger, Jack F. M. Wetzels, Nicole C. A. J. van de Kar, Rob ter Heine
Summary: This study evaluated the pharmacokinetics and pharmacodynamics of eculizumab in patients with atypical haemolytic uraemic syndrome (aHUS) and proposed improved dosing strategies. The study found that individualized dosing strategy could improve treatment response and reduce treatment costs by prolonging the dosing interval.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Yaxin Liu, Yun Kuang, Min Hai, Cheng Cui, Dongyang Liu, Guoping Yang
Summary: The exposure to ticagrelor is higher in East Asians, resulting in an increased risk of bleeding. A population pharmacokinetic model was developed and machine learning methods were used to construct bleeding risk models. The Random Forest model performed the best and a lower bleeding risk ticagrelor regimen can be obtained using this model.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
Wenqiang Zhou, Wenjuan Nie, Qingfeng Wang, Wenhui Shi, Yang Yang, Qi Li, Hui Zhu, Zhongquan Liu, Yangming Ding, Yu Lu, Naihui Chu
Summary: This study aimed to find the optimal dosing regimen of linezolid in different populations. The results revealed that factors such as body weight and creatinine clearance significantly influenced the pharmacokinetics of linezolid. The study determined the optimal dosage regimens for patients with different body weights and MIC values, and found that single dosing was safer than multiple dosing.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, Research & Experimental
Zhiyong Du, Yingyuan Lu, Jiaxu Sun, Kun Chang, Mengqiu Lu, Meng Fang, Xiangrui Zeng, Wenxin Zhang, Jinyang Song, Xiaoyu Guo, Pengfei Tu, Yong Jiang
Summary: This study utilized PK/PM-PD and multivariate biological correlation network strategy to investigate the active components and synergistic mechanisms of Baoyuan decoction (BYD) against cardiac hypertrophy (CH). The results revealed that bioavailable BYD-compounds, such as saponins and flavonoids, showed positive or negative correlations with various CH-altered metabolites and PD-indicators during treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Aditya H. Gaur, John C. Panetta, Amber M. Smith, Ronald H. Dallas, Burgess B. FreemanIII, Tracy B. Stewart, Li Tang, Elizabeth John, Kristen C. Branum, Nehali D. Patel, Shelley Ost, Ryan N. Heine, Julie L. Richardson, Jared T. Hammill, Lidiya Bebrevska, Fabian Gusovsky, Noritsugu Maki, Toshiharu Yanagi, Patricia M. Flynn, James S. McCarthy, Stephan Chalon, R. Kiplin Guy
Summary: The study investigated the safety, tolerability, and pharmacokinetics of a multidose SJ733 regimen and a single-dose pharmacoboost approach using cobicistat to inhibit CYP3A4. The results showed that both approaches were well-tolerated and significantly increased drug exposure and prediction of cure.
Article
Infectious Diseases
Michael Samarkos, Konstantinos Papanikolaou, Athena Sourdi, Nikolaos Paisios, Efstratios Mainas, Elisabeth Paramythiotou, Anastasia Antoniadou, Helen Sambatakou, Panayiotis Gargalianos-Kakolyris, Athanasios Skoutelis, George L. Daikos
Summary: This study examined the effects of once-daily versus twice- or thrice-daily dosing of colistin on renal function. The results showed that once-daily dosing of colistin is not more nephrotoxic than the standard dosing regimens. The only independent predictor of nephrotoxicity was diabetes mellitus, while eGFR > 80 mL/min had a protective effect.
Article
Respiratory System
Huahe Zhu, Shun Wang, Cong Shan, Xiaoqian Li, Bo Tan, Qilong Chen, Yunxiang Yang, Hongji Yu, Aidong Yang
Summary: Xuan-bai-cheng-qi decoction (XCD) is a traditional Chinese medicine prescription used to treat respiratory diseases, particularly acute lung injury (ALI). Network pharmacology and RNA sequencing results suggest that XCD may protect against ALI by regulating the PI3K/mTOR/HIF-1 alpha/VEGF signaling pathway.
RESPIRATORY RESEARCH
(2021)