Journal
VIRUS RESEARCH
Volume 242, Issue -, Pages 79-84Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2017.09.012
Keywords
Human adenovirus; Complete genome; HAdV-84; Homologous recombination; HAdV-D; Acute respiratory disease
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Funding
- FP7 Marie Curie Actions via the ADVEC consortium [324325]
- Lovelace Respiratory Research Institute
- SNIC through Uppsala Multidisciplinary Centre for Advanced Computational Science (UPPMAX) [b2014163]
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A novel human adenovirus was isolated from a pediatric case of acute respiratory disease in Panama City, Panama in 2011. The clinical isolate was initially identified as an intertypic recombinant based on hexon and fiber gene sequencing. Based on the analysis of its complete genome sequence, the novel complex recombinant Human mastadenovirus D (HAdV-D) strain was classified into a new HAdV type: HAdV-84, and it was designated Adenovirus D human/PAN/P309886/2011/84[P43H17F84]. HAdV-D types possess usually an ocular or gastrointestinal tropism, and respiratory association is scarcely reported. The virus has a novel fiber type, most closely related to, but still clearly distant from that of HAdV-36. The predicted fiber is hypothesised to bind sialic acid with lower affinity compared to HAdV-37. Bioinformatic analysis of the complete genomic sequence of HAdV-84 revealed multiple homologous recombination events and provided deeper insight into HAdV evolution.
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