Article
Virology
Francesca Colavita, Alessandra Oliva, Aurora Bettini, Andrea Antinori, Enrico Girardi, Concetta Castilletti, Francesco Vaia, Giuseppina Liuzzi
Summary: A study has found that antibodies produced after COVID-19 vaccination can pass through the placenta and provide passive immunity to newborns. Understanding the maternal response to vaccination and the persistence of antibodies in infants is critical for optimizing maternal immunization regimens.
Article
Immunology
Athena P. Y. Li, Carolyn A. Cohen, Nancy H. L. Leung, Vicky J. Fang, Shivaprakash Gangappa, Suryaprakash Sambhara, Min Z. Levine, A. Danielle Iuliano, Ranawaka A. P. M. Perera, Dennis K. M. Ip, J. S. Malik Peiris, Mark G. Thompson, Benjamin J. Cowling, Sophie A. Valkenburg
Summary: The study indicates that using vaccines with higher antigen content or adjuvants can enhance the efficacy of standard-dose seasonal influenza vaccines in older adults. Enhanced vaccines showed better induction of specific antibodies and cellular responses compared to standard-dose vaccines, especially in enhancing cellular cytotoxicity and T cell responses.
Article
Immunology
Barbara Poniedzialek, Ewelina Hallmann, Dominika Sikora, Karol Szymanski, Katarzyna Kondratiuk, Jakub Zurawski, Piotr Rzymski, Lidia Brydak
Summary: Evidence suggests that vaccination against seasonal influenza can enhance innate immune responses to COVID-19 and reduce disease severity. This study aimed to compare humoral responses to SARS-CoV-2 in non-hospitalized, COVID-19 unvaccinated patients and mild COVID-19 convalescent patients who were and were not vaccinated against influenza. The results showed that influenza-vaccinated patients had higher levels of antibodies against nucleocapsid and receptor binding domain compared to non-vaccinated patients.
Review
Microbiology
Ana Vazquez-Pagan, Stacey Schultz-Cherry
Summary: This article highlights the high risk of severe influenza for pregnant women, newborns, and infants under six months old, emphasizing the importance of vertically transferred immunity. It summarizes novel insights from recent studies and discusses the impact of maternal antibodies on early life immunity, stressing the need for continued research using pregnant animal models and including pregnant women in evaluating novel vaccine platforms.
Article
Multidisciplinary Sciences
Caroline G. Atyeo, Lydia L. Shook, Sara Brigida, Rose M. De Guzman, Stepan Demidkin, Cordelia Muir, Babatunde Akinwunmi, Arantxa Medina Baez, Erin McSweeney, Madeleine Burns, Ruhi Nayak, Maya K. Kumar, Chinmay D. Patel, Allison Fialkowski, Dana Cvrk, Ilona T. Goldfarb, Lael M. Yonker, Alessio Fasano, Alejandro B. Balazs, Michal A. Elovitz, Kathryn J. Gray, Galit Alter, Andrea G. Edlow
Summary: Pregnant individuals infected with SARS-CoV-2 are at high risk of complications, but little is known about the immune response and antibody transfer from COVID-19 vaccines in different trimesters. This study characterizes the antibody response and transplacental transfer in pregnant individuals who received Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. The findings show differences in vaccine-induced functions, receptor-binding, and efficacy against variants of concern. First and third trimester vaccination enhances maternal immune response and antibody transfer compared to the second trimester. These results provide valuable insights into the effect of vaccine platform and timing on maternal immune response and transplacental antibody transfer.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Laura Sanchez-de Prada, Ivan Sanz-Munoz, Raul Ortiz de Lejarazu, Jose Maria Eiros, Adolfo Garcia-Sastre, Teresa Aydillo
Summary: Current influenza vaccines induce humoral immune responses against the HA protein, with Sb and Ca2 antigenic sites showing high immunodominance. Elderly individuals have lower pre-vaccination antibody levels, while young adults have lower levels only at the Sb and Ca2 sites. After vaccination, ATIV reduces humoral responses to all viruses, while QIV only reduces responses to Sb and Ca2.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Shinya Tsuzuki, Fumiko Murata, Megumi Maeda, Yusuke Asai, Ryuji Koizumi, Norio Ohmagari, Haruhisa Fukuda
Summary: The study aimed to examine the association between seasonal influenza vaccination and antimicrobial use in Japan, as well as the impact of influenza vaccination on the frequency of unnecessary antimicrobial prescription for upper respiratory infection. The results showed that seasonal influenza vaccination was associated with lower frequencies of unnecessary antibiotic prescription and healthcare facility consultation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Obstetrics & Gynecology
Matthew J. Zuber, David M. Stamilio, Beth C. Holbrook, Beverly M. Snively, Elizabeth T. Jensen, Martha A. Alexander-Miller
Summary: The objective of this study was to evaluate the antibody response to the influenza vaccine during pregnancy and its transfer to the infant. The results showed that hemagglutinin stem-specific IgG was boosted more robustly than whole vaccine titers. Additionally, hemagglutinin stem-specific IgG was found to be concentrated in cord blood and dominated by IgG1 subclass.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Immunology
Niloufar Kavian, Asmaa Hachim, Benjamin J. Cowling, Sophie A. Valkenburg
Summary: The timing of influenza vaccination and antigenic change impact the quality of immune responses. Staggered vaccination with two different H3N2 strains can result in higher antibody and B-cell memory responses. Both staggered and cumulative vaccination provide protection from lethal-drifted H3N2 virus challenge, while reducing lung IL-6 and inflammation levels.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Cynthia M. Rand, Robin Bender, Sharon G. Humiston, Christina Albertin, Courtney Olson-Chen, Judy Chen, Yung-Shee J. Hsu, Sitaram Vangala, Peter G. Szilagyi
Summary: This study assessed obstetric providers' attitudes and practices related to influenza and Tdap vaccination in four large health systems in New York (NY) and California (CA). The results showed that although most providers considered maternal vaccination important, there is room for improvement in increasing vaccination rates and emphasizing the importance of maternal vaccination for infant health.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Cynthia M. Rand, Robin Bender, Sharon G. Humiston, Christina Albertin, Courtney Olson-Chen, Judy Chen, Yung-Shee J. Hsu, Sitaram Vangala, Peter G. Szilagyi
Summary: This study assessed obstetric providers' attitudes and practices related to influenza and Tdap vaccination in four large health systems in New York and California. Results showed that while most providers consider influenza and Tdap vaccination important during pregnancy, there is room for improvement in focusing on the importance of maternal vaccination to the health of the infant, and increasing the use of office systems to improve vaccination during pregnancy.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Cell Biology
Mimi M. M. Hou, Jordan R. R. Barrett, Yrene Themistocleous, Thomas A. A. Rawlinson, Ababacar Diouf, Francisco J. J. Martinez, Carolyn M. M. Nielsen, Amelia M. M. Lias, Lloyd D. W. King, Nick J. J. Edwards, Nicola M. M. Greenwood, Lucy Kingham, Ian D. D. Poulton, Baktash Khozoee, Cyndi Goh, Susanne H. H. Hodgson, Dylan J. J. Mac Lochlainn, Jo Salkeld, Micheline Guillotte-Blisnick, Christele Huon, Franziska Mohring, Jenny M. M. Reimer, Virander S. S. Chauhan, Paushali Mukherjee, Sumi Biswas, Iona J. J. Taylor, Alison M. M. Lawrie, Jee-Sun Cho, Fay L. L. Nugent, Carole A. A. Long, Robert W. W. Moon, Kazutoyo Miura, Sarah E. E. Silk, Chetan E. E. Chitnis, Angela M. M. Minassian, Simon J. J. Draper
Summary: Two clinical trials were conducted to evaluate two vaccines against Plasmodium vivax. The PvDBPII/Matrix-M vaccine, given in a delayed dosing regimen, showed the highest antibody responses and reduced parasite multiplication rate by 51% compared to controls. These results support further evaluation of the PvDBPII/Matrix-M P. vivax vaccine.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pediatrics
Stacey L. Rowe, Karin Leder, Kirsten P. Perrett, Nicole Romero, Terry M. Nolan, Nicola Stephens, Benjamin C. Cowie, Allen C. Cheng
Summary: This study demonstrates the direct effectiveness of maternal influenza and pertussis vaccination in preventing these diseases in infants aged <2 months. The findings emphasize the significance of maternal vaccination in preventing these diseases in infants.
Article
Immunology
Nina Urke Ertesvag, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G- Mohn, Karl Albert Brokstad, Mai-Chi Trieu
Summary: This study investigated the breadth and durability of influenza A/H3N2-specific antibodies in children and adults. It found that childhood infection increased adult antibody responses, and repeatedly vaccinated adults had broader and more durable antibodies.
Review
Public, Environmental & Occupational Health
Zakieh Ostad-Ahmadi, Sara Boccalini, Amin Daemi, Alireza Mahboub-Ahari
Summary: This study conducted a systematic search and found that almost all studies indicate that vaccinating pregnant women against influenza is a cost-effective and cost-saving strategy. However, in one study, the lack of data for pregnant women led to the conclusion that it was not cost-effective when using costs and probabilities related to other groups. The main factors influencing the cost-effectiveness were vaccine efficacy and vaccination cost. Hence, influenza vaccination of pregnant women is a cost-effective intervention.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Karl G. Nicholson, Catherine I. Thompson, Jaco M. Klap, John M. Wood, Sally Batham, Robert W. Newman, Robert Mischler, Maria C. Zambon, Iain Stephenson
Article
Immunology
Valerie Kuenzi, Jaco M. Klap, Michael K. Seiberling, Christian Herzog, Katharina Hartmann, Oliver Kuersteiner, Ronald Kompier, Roberto Grimaldi, Jaap Goudsmit
Article
Immunology
Arine Rodriguez, Ratna Mintardjo, Dennis Tax, Gert Gillissen, Jerome Custers, Maria Grazia Pau, Jaco Klap, Sampa Santra, Harikrishnan Balachandran, Norman L. Letvin, Jaap Goudsmit, K. Radosevic
Article
Immunology
Rebecca J. Cox, Gabriel Pedersen, Abdullah S. Madhun, Signe Svindland, Marianne Saevik, Lucy Breakwell, Katja Hoschler, Marieke Willemsen, Laura Campitelli, Jane Kristin Nostbakken, Gerrit Jan Weverling, Jaco Klap, Kenneth C. McCullough, Maria Zambon, Ronald Kompier, Haakon Sjursen
Article
Multidisciplinary Sciences
Maria J. P. van Dongen, Rameshwar U. Kadam, Jarek Juraszek, Edward Lawson, Boerries Brandenburg, Frederike Schmitz, Wim B. G. Schepens, Bart Stoops, Harry A. van Diepen, Mandy Jongeneelen, Chan Tang, Jan Vermond, Alida van Eijgen-Obregoso Real, Sven Blokland, Divita Garg, Wenli Yu, Wouter Goutier, Ellen Lanckacker, Jaco M. Klap, Danielle C. G. Peeters, Jin Wu, Christophe Buyck, Tim H. M. Jonckers, Dirk Roymans, Peter Roevens, Ronald Vogels, Wouter Koudstaal, Robert H. E. Friesen, Pierre Raboisson, Dashyant Dhanak, Jaap Goudsmit, Ian A. Wilson
Article
Public, Environmental & Occupational Health
Reem Waziry, Luuk Gras, Sanaz Sedaghat, Henning Tiemeier, Gerrit J. Weverling, Mohsen Ghanbari, Jaco Klap, Frank de Wolf, Albert Hofman, M. Arfan Ikram, Jaap Goudsmit
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Genetics & Heredity
Michelle M. J. Mens, Silvana C. E. Maas, Jaco Klap, Gerrit Jan Weverling, Paul Klatser, Just P. J. Brakenhoff, Joyce B. J. van Meurs, Andre G. Uitterlinden, M. Arfan Ikram, Maryam Kavousi, Mohsen Ghanbari
FRONTIERS IN GENETICS
(2020)
Article
Clinical Neurology
Frank de Wolfa, Mohsen Ghanbaria, Silvan Lichera, Kevin McRae-McKeea, Luuk Grasa, Gerrit Jan Weverlinga, Paulien Wermelinga, Sanaz Sedaghata, M. Kamran Ikrama, Reem Wazirya, Wouter Koudstaala, Jaco Klapa, Stefan Kostensea, Albert Hofmana, Roy Andersona, Jaap Goudsmita, M. Arfan Ikrama
Meeting Abstract
Public, Environmental & Occupational Health
Ariane Rodriguez, Ratna Mintardjo, Dennis Tax, Gert Gillissen, Jerome Custer, Maria G. Pau, Jaco Klap, Sampa Santra, Harikrishnan Balachandran, Norman L. Letvin, Jaap Goudsmit, Katarina Radosevic
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2009)
Article
Immunology
Olga J. A. E. Ophorst, Katarina Radosevic, Jaco M. Klap, Jeroen Sijtsma, Gert Gillissen, Ratna Mintardjo, Mark J. M. van Ooij, Lennart Holterman, Arjen Companjen, Jaap Goudsmit, Menzo J. E. Havenga
Article
Forestry
W de Vries, E Vel, GJ Reinds, H Deelstra, JM Klap, EEJM Leeters, CMA Hendriks, M Kerkvoorden, G Landmann, J Herkendell, T Haussmann, JW Erisman
FOREST ECOLOGY AND MANAGEMENT
(2003)
Article
Environmental Sciences
EP Van Leeuwen, KCMA Hendriks, JM Klap, W De Vries, E De Jong, JW Erisman
WATER AIR AND SOIL POLLUTION
(2000)
Article
Environmental Sciences
JM Klap, JHO Voshaar, W De Vries, JW Erisman
WATER AIR AND SOIL POLLUTION
(2000)
Article
Environmental Sciences
W De Vries, JM Klap, JW Erisman
WATER AIR AND SOIL POLLUTION
(2000)