Article
Chemistry, Physical
Han-Kyu Choi, Sang-Min Park, Jeeyoon Jeong, Hankyul Lee, Gyu Jin Yeon, Dai-Sik Kim, Zee Hwan Kim
Summary: In this study, a simple photolithographic method was demonstrated to generate highly sensitive SERS hot spot structures at desired positions. The solid-state dewetting of an Ag thin film using a continuous-wave laser resulted in the formation of closely packed assemblies of hemispherical Ag nanoislands with substantial plasmonic-field enhancement. These hot spot structures can be utilized as position-specific chemical-sensing elements in integrated analytical devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Environmental Sciences
Michael W. Duffel, Kristopher Tuttle, Hans-Joachim Lehmler, Larry W. Robertson
Summary: PCB sulfates bind reversibly with high affinity to human serum proteins, are taken up by cells and tissues, and may be hydrolyzed to more toxic OH-PCBs. Human hepatic microsomal sulfatase can catalyze the hydrolysis of PCB sulfates to OH-PCBs, potentially contributing to the retention and increased exposure time of OH-PCBs.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Mengxiang Song, Deming Huang, Nan Huo, Essy Kouadio Fodjo, Wei Deng, Dan Li
Summary: This study developed a stimulus-responsive three-dimensional microgel decorated with nanoparticles, which allows precise control of hot spots region by regulating temperature and moisture. It can simultaneously regulate structures and capture target molecules, as well as self-clean, achieving recyclable and reliable SERS analysis of solid samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Mei Zhu, Moxia Li, Mengke Su, Jianfang Liu, Bingwu Liu, Yongjie Ge, Honglin Liu, Jiawen Hu
Summary: The instability of hot spots is a key limiting factor for the poor spectral reproducibility of SERS. Hot spots exhibit stability thresholds to excitation power, duration, and wavelength. Lowering the excitation power below the threshold or deliberately removing unstable hot spots can significantly improve the stability and reproducibility of SERS signals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Review
Engineering, Environmental
Auwalu Hassan, Fauziah S. Hamid, Agamuthu Pariatamby, Nurul Shamsinah M. Suhaimi, Noor Maiza binti M. Razali, Kimberly N. H. Ling, Priya Mohan
Summary: This review provides a detailed overview of bioremediation technologies for PCB-contaminated environments, discusses bioaugmentation approaches for treating contaminated soil, sediment, and wastewater, explores limitations and strategies to improve efficiency, gives an update on PCB biodegradation studies and mechanisms, and explores future research prospects based on the reviewed articles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Longkun Yang, Zhifang Ren, Meng Zhang, Yanli Song, Pan Li, Yun Qiu, Pingye Deng, Zhipeng Li
Summary: The three-dimensional porous SERS powder material, engineered with Ag nanoparticles on silica aerogel, shows great potential for highly sensitive analyte enrichment and near field enhancement. The material exhibits stable calibration curves, making it suitable for quantitative analysis, and can be utilized for on-site SERS applications in chemical analysis, environmental monitoring, and anti-terrorism.
NANOSCALE ADVANCES
(2021)
Correction
Chemistry, Physical
Xuan-Hung Pham, Eunil Hahm, Tae Han Kim, Hyung-Mo Kim, Sang Hun Lee, SangChul Lee, Homan Kang, Ho-Young Lee, Dae Hong Jeong, Hak Soo Choi, Bong-Hyun Jun
Summary: The author name and corresponding affiliation in the original version of this article were mistakenly labeled.
Article
Plant Sciences
Cuiting Wang, Yuan Sun, Honghua Ruan, Jing Yang
Summary: This study investigated the effects of PCB-28 on Lemna minor plants, finding that high concentrations of PCB-28 negatively impacted growth, photosynthesis characteristics, and the antioxidant defense system, while low concentrations had no significant effects. Additionally, exposure to PCB-28 damaged the chloroplast ultrastructure. This work contributes valuable data on PCB-induced phytotoxicity physiology and biochemistry.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Engineering, Environmental
Thomas Schettgen, Andre Esser, Anne Alt, Isabella Randerath, Thomas Kraus, Patrick Ziegler
Summary: This study investigated the internal exposure of employees in a German silicone rubber facility to decomposition products of 2,4-dichlorobenzoyl peroxide. The results showed a considerable uptake of these products in workers from all work areas, with individual levels depending on the work task. The presence of carcinogenic PCBs in the samples raises concerns for the workers' additional exposure to these substances.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Marine Lemaitre, Pauline Frenoy, Thibault Fiolet, Caroline Besson, Francesca Romana Mancini
Summary: This study analyzed the relationship between dietary exposure to DL and NDL PCB and NHL risk, finding a positive association between DL PCB and Diffuse Large B Cell Lymphoma, and a negative association between NDL PCB and follicular lymphoma. However, these associations were no longer significant when fish and dairy product consumption was adjusted for.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Shuang Wang, Jibing Li, Longfei Jiang, Shanquan Wang, Xuan Zhao, Yeliang Dai, Chunling Luo, Gan Zhang
Summary: The study applied stable-isotope probing to investigate the degradation of PCBs mediated by RD-AO, confirming the impact of the anaerobic stage on subsequent AO and its potential mechanism. Additionally, four lineages (Arenimonas, Steroidobacter, Sulfurifustis, and Thermoanaerobacterales) were identified as PCB degraders for the first time, suggesting the recruitment of novel bacteria involved in PCB aerobic degradation in the anaerobic-aerobic two-stage treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Yazan Bdour, Graham Beaton, Juan Gomez-Cruz, Oscar Cabezuelo, Kevin Stamplecoskie, Carlos Escobedo
Summary: A surface-enhanced Raman scattering (SERS) active metasurface composed of metallic nanohole arrays and metallic nanoparticles has been developed. The metasurface can operate in aqueous environments, achieving an enhancement factor of 1.83 x 10(9) for Rhodamine 6G, and enabling the detection of malachite green at a concentration of 0.46 ppb.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Chi Zhang, Soumik Siddhanta, Debadrita Paria, Yaozheng Li, Chao Zheng, Ishan Barman
Summary: A novel nano-PROD platform has been developed for molecular recording by probing vibrational modes of membrane constituents, sustaining live cells in near-physiological conditions and enabling surface-enhanced Raman spectroscopy analysis of specific cell surface markers. This platform shows promise for a range of applications due to its tunability and unique combination of nanoscale topographic features and molecular sensing capabilities.
Article
Chemistry, Physical
Wei Zhang, Tianxing Zheng, Bin Ai, Panpan Gu, Yuduo Guan, Yu Wang, Zhiyuan Zhao, Gang Zhang
Summary: Au-P-Au-coupled gold nanoparticle platforms with multiple nanogaps were fabricated using nanoskiving and polymer-assisted assembly. The platform showed strong electric field enhancement due to the confinement of incident light, leading to significant surface-enhanced Raman scattering performance and sensitive detection of glucose.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Ya-Qiong Su, Jia Liu, Rong Huang, Hong-Tao Yang, Ming-Xue Li, Ran Pang, Meng Zhang, Meng-Han Yang, Hai-Feng Su, Rajkumar Devasenathipathy, Yuan-Fei Wu, Jian-Zhang Zhou, De-Yin Wu, Su-Yuan Xie, Bing-Wei Mao, Zhong-Qun Tian
Summary: Surface-enhanced Raman spectroscopy (SERS) is widely usedfor efficient identification and characterization of DNA structures. The SERS signals of the adenine group show high detection sensitivity in various biomolecular systems. However, there is still no consensus on the interpretation of certain types of SERS signals of adenine and its derivatives on silver colloids and electrodes. This study introduces a new photochemical azo coupling reaction for adenyl residues, which selectively oxidizes adenine to azopurine in the presence of silver ions, silver colloids, and nanostructured electrodes under visible light irradiation. The resulting azopurine is found to be responsible for the SERS signals. This photoelectrochemical oxidative coupling reaction is facilitated by plasmon-mediated hot holes and regulated by positive potentials and solution pH, providing new insights into the study of azo coupling in the photoelectrochemistry of adenine-containing biomolecules on plasmonic metal nanostructure electrodes.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Applied
Fatemeh Ajalloueian, Priscila R. Guerra, Martin Iain Bahl, Anders Meyer Torp, En Te Hwu, Tine Rask Licht, Anja Boisen
Summary: In this study, encapsulation of the probiotic strain Lactobacillus rhamnosus GG (LGG) into electrospun pullulan nanofibers with PLGA layers showed enhanced viability and successful delivery in vitro and in vivo. The multilayer construct provided increased protection and potential mucoadhesion properties, demonstrating potential for commercial interest in protecting sensitive probiotics from oxygen and gastric conditions.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Anders Meyer Torp, Martin Iain Bahl, Anja Boisen, Tine Rask Licht
Summary: This article reviews the challenges in developing next generation probiotic products, evaluates the current microbial processing and delivery techniques for oxygen-sensitive probiotics, and discusses possible process optimizations. The current microbial processing techniques are not suitable for next generation probiotics, necessitating the need for optimization or entirely novel approaches. Oral delivery of live next generation probiotics is poorly studied, suggesting the potential for novel delivery vehicles such as microparticles and microdevices.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nikolaj Kofoed Mandsberg, Wenting Liao, Yoshihiro Alexander Yamanouchi, Anja Boisen, Hirotaka Ejima
Summary: The study shows that metal-phenolic networks can successfully encapsulate green algae, delaying cell proliferation, adsorption, and enhancing harvest efficiency, providing new possibilities for surface engineering applications of green algae.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Pharmacology & Pharmacy
Thomas Rades, Anja Boisen, Anette Muellertz, Maja Norgaard Kristensen
Summary: This study investigated the impact of three oral gavage techniques on gastrointestinal transit and drug absorption. The results showed that piston-dosing was the superior technique for promoting drug absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Xin-Feng Wei, Tomas Rindzevicius, Kaiyu Wu, Martin Bohlen, Mikael Hedenqvist, Anja Boisen, Aron Hakonen
Summary: Despite the growing global production and use of plastics, which generates vast amounts of plastic waste and micmplastics in the marine environment, a new method based on plasmon-enhanced fluorescence (PEF) was developed to detect microplastics in highly diluted natural samples. The method utilizes gold nanopillar-based substrates to enhance the fluorescence emission signal from microplastics in water samples and has a low limit of detection and quantification. This new method enables the visualization of undyed microplastics in fluorescence microscopy, even particles and fibers too small to be imaged with conventional light microscopy, making it a valuable tool for microplastic research.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yaman Goksel, Elodie Dumont, Roman Slipets, Sriram T. Rajendran, Sevde Sarikaya, Lasse H. E. Thamdrup, Kjeld Schmiegelow, Tomas Rindzevicius, Kinga Zor, Anja Boisen
Summary: Therapeutic drug monitoring (TDM) is crucial for optimizing drug dosing and avoiding adverse effects. In this study, an electrochemically assisted surface-enhanced Raman spectroscopy (SERS) method and a benchtop Raman detection system were developed for the detection of methotrexate (MTX). The method showed promising results and can be used in resource-limited environments.
Article
Chemistry, Multidisciplinary
Philip H. R. Carlsen, Rolf Bech Kjeldsen, Gabriel K. Pedersen, Dennis Christensen, Line Hagner Nielsen, Anja Boisen
Summary: Oral vaccination has gained attention recently due to patient compliance and logistics. However, developing oral subunit vaccines is challenging. Micro technology, such as Microcontainers (MCs), can be used to overcome these challenges by facilitating protection and effective delivery of vaccine components in the gastrointestinal tract. The study tests MCs for oral delivery of the C. trachomatis vaccine candidate CTH522, and finds that alpha-GalCer is the most efficient adjuvant for the oral vaccine. The study also suggests that larger animals should be used in future trials with MCs due to potential clearance issues in mice.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Tijana Maric, Vaios Adamakis, Zhongyang Zhang, Carmen Milian-Guimera, Lasse Hojlund Eklund Thamdrup, Eugen Stamate, Mahdi Ghavami, Anja Boisen
Summary: For macromolecules and poorly permeable drugs, oral drug delivery often suffers from low bioavailability and absorption. To address this issue, a cascade delivery device comprising Magnesium-based Janus micromotors (MMs) inside microscale containers (MCs) has been proposed. This device aims to facilitate targeted drug delivery by allowing MMs to lodge within the intestinal mucosa. Loading MMs into MCs can potentially enhance drug absorption through increased proximity and unidirectional release. The concept of dual-acting cascade devices holds great potential in applications that require proximity to the epithelium and deep mucus penetration.
Article
Engineering, Biomedical
Tijana Maric, Amalie Lovind, Zhongyang Zhang, Jiayue Geng, Anja Boisen
Summary: In this study, gold-coated mesoporous silica nanoparticles are developed as nanomotors driven by near-infrared light. These nanomotors can propel themselves through biofilms and disperse them through photothermal effect. The velocities of the nanomotors are found to increase with increasing laser power, and they show excellent capabilities to eradicate Pseudomonas aeruginosa biofilms even under short irradiation time. This study holds great promise for overcoming challenges in bacterial biofilm eradication.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Tien-Jen Chang, Rolf Bech Kjeldsen, Juliane Fjelrad Christfort, Eduard Marzo Vila, Tommy Sonne Alstrom, Kinga Zor, En-Te Hwu, Line Hagner Nielsen, Anja Boisen
Summary: This study investigates the use of microscale stereolithography 3D printing to fabricate radiopaque microcontainers with enhanced mucoadhesive geometries, aiming to improve bioavailability. The results show that microcontainers with adhering features exhibit increased mucoadhesion. In vivo studies using imaging techniques reveal the time-dependent gastrointestinal location and spatial dynamics of microcontainers.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Haipeng Li, Elodie Dumont, Roman Slipets, Thomas Thersleff, Anja Boisen, Georgios A. Sotiriou
Summary: Pesticide residues in food products are a concern for human health, and their rapid and easy detection is necessary. The surface-enhanced Raman scattering (SERS) technique can detect pesticide residues quickly and reliably, but its application in food safety diagnostics is limited by its high cost, low scalability, and low reproducibility of necessary sensors. In this study, we have developed a low-cost, large-scale, and highly reproducible method for fabricating SERS nano-sensors, based on the direct deposition of plasmonic core-shell structured Ag-SiO2 nanoparticles produced in the gas phase on temperature-controlled inexpensive glass substrates. Our highly sensitive SERS substrates can rapidly and quantitatively detect pesticide residues in fresh orange, demonstrating their practical applicability for food safety diagnostics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Mahdi Ghavami, Jesper Pedersen, Rolf Bech Kjeldsen, Aage Kristian Olsen Alstrup, Zhongyang Zhang, Vasiliki Koulianou, Johan Palmfeldt, Thomas Vorup-Jensen, Lasse Hojlund Eklund Thamdrup, Anja Boisen
Summary: In this study, researchers developed a new generation of medical devices called self-unfolding proximity enabling devices, which can orally deliver macromolecules without perforating the intestine. These devices protect the macromolecules from harsh conditions in the stomach and release their active pharmaceutical ingredients near the intestinal epithelium. One version of the device, a self-unfolding foil, was used to deliver insulin and nisin to rats and pigs, resulting in a significant increase in absorption.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemical Research Methods
Laura Serioli, Lina Gruzinskyte, Giulia Zappala, En Te Hwu, Trygvi Zachariassen Laksafoss, Peter Lunding Jensen, Danilo Demarchi, Anette Mullertz, Anja Boisen, Kinga Zor
Summary: The CMoD platform is a compact centrifugal device that utilizes artificial intelligence software for real-time monitoring of cell culture and drug interaction under flow conditions. It can accurately analyze cell images and provide data on cell viability and toxicity.
Review
Chemistry, Multidisciplinary
Carmen Milian-Guimera, Reece Mccabe, Lasse Hojlund Eklund Thamdrup, Mahdi Ghavami, Anja Boisen
Summary: Oral dosage forms are the preferred solution for systemic treatment and prevention of diseases, but traditional forms face challenges. Research on novel formulation strategies for oral drug delivery has bloomed in the last decade to overcome these challenges, with approaches based on drug release and mucus interfacing showing promising results in personalized medicine and improved bioavailability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Microbiology
Pi Westi Bondegaard, Anders Meyer Torp, Priscila Guerra, Katja Ann Kristensen, Juliane Fjelrad Christfort, Karen Angeliki Krogfelt, Line Hagner Nielsen, Kinga Zor, Anja Boisen, Martin Steen Mortensen, Martin Iain Bahl, Tine Rask Licht
Summary: The use of microcontainers did not provide a competitive advantage for the probiotic E. coli Nissle in colonizing the gut of mice. Alternative approaches are needed to enhance the competitive capacity of EcN in the gut.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Chemistry, Analytical
Elena Naumovska, Gabriel Kofi Nzulu, Laura Mazzei, Arnaud Le Febvrier, Kristina Komander, Martin Magnuson, Max Wolff, Per Eklund, Maths Karlsson
Summary: Results from an infrared spectroscopy study on hydrated nanocrystalline films of BaZr1-xScxO3-x/2 with different Sc concentrations show variations in the O-H stretching bands, indicating different proton configurations. Higher Sc concentrations exhibit a distinct O-H stretching band, while lower Sc concentrations show a broader, weaker band.
VIBRATIONAL SPECTROSCOPY
(2024)
