Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – A post-hoc analysis of a Phase 3, single-arm, open-label trial

(2015) C. Stefanutti et al.   ATHEROSCLEROSIS

Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease

(2015) A. M. Navar-Boggan et al.   CIRCULATION

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial

(2015) Frederick J Raal et al.   LANCET

Reduction of Low-Density Lipoprotein Cholesterol by Monoclonal Antibody Inhibition of PCSK9

(2014) Evan A. Stein et al.   Annual Review of Medicine

Effect of rosuvastatin therapy on carotid intima media thickness in children with familial hypercholesterolemia: Findings from the charon study

(2014) M.J.A.M. Braamskamp et al.   ATHEROSCLEROSIS

Markers of atherosclerotic development in children with familial hypercholesterolemia: A literature review

(2014) Ingunn Narverud et al.   ATHEROSCLEROSIS

Premature atherosclerosis is not systematic in phytosterolemic patients: Severe hypercholesterolemia as a confounding factor in five subjects

(2014) Boris Hansel et al.   ATHEROSCLEROSIS

Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: A study of a cohort of 14,000 mutation carriers

(2014) Joost Besseling et al.   ATHEROSCLEROSIS

Impact of Early Evidence of Atherosclerotic Changes on Early Treatment in Children With Familial Hypercholesterolemia

(2014) Željko Reiner   CIRCULATION RESEARCH

Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype–phenotype relationship, and clinical outcome

(2014) Barbara Sjouke et al.   EUROPEAN HEART JOURNAL

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

(2014) M. Cuchel et al.   EUROPEAN HEART JOURNAL

Optimising the Detection and Management of Familial Hypercholesterolaemia: Central Role of Primary Care and its Integration with Specialist Services

(2014) Alistair W. Vickery et al.   Heart Lung and Circulation

Ten-Year Follow-up After Initiation of Statin Therapy in Children With Familial Hypercholesterolemia

(2014) D. Meeike Kusters et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cascade screening based on genetic testing is cost-effective: Evidence for the implementation of models of care for familial hypercholesterolemia

(2014) Zanfina Ademi et al.   Journal of Clinical Lipidology

Management of familial hypercholesterolemia in children and adolescents. Position paper of the Polish Lipid Expert Forum

(2014) Małgorzata Myśliwiec et al.   Journal of Clinical Lipidology

A Double-Blind Randomized Trial of Fish Oil to Lower Triglycerides and Improve Cardiometabolic Risk in Adolescents

(2014) Samuel S. Gidding et al.   JOURNAL OF PEDIATRICS

Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia

(2014) Diederik F. van Wijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Curing Atherosclerosis Should Be the Next Major Cardiovascular Prevention Goal

(2014) Jennifer G. Robinson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

(2014) Ron Do et al.   NATURE

Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry

(2013) Emily C. O’Brien et al.   AMERICAN HEART JOURNAL

APOE p.Leu167del mutation in familial hypercholesterolemia

(2013) Zuhier Awan et al.   ATHEROSCLEROSIS

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

(2013) Helena Gylling et al.   ATHEROSCLEROSIS

The evidence-base for the efficacy of lipoprotein apheresis in combating cardiovascular disease

(2013) Gilbert R. Thompson   ATHEROSCLEROSIS SUPPLEMENTS

Carotid Intima-Media Thickness in Children With Familial Hypercholesterolemia

(2013) Dorothé M. Kusters et al.   CIRCULATION RESEARCH

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

(2013) B. G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Trans fatty acids and cardiovascular health: research completed?

(2013) I A Brouwer et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation

(2013) Gerald F. Watts et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Implementation of Lipid Screening Guidelines in Children by Primary Pediatric Providers

(2013) Damon B. Dixon et al.   JOURNAL OF PEDIATRICS

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

(2013) Philippa J Talmud et al.   LANCET

Low-Density Lipoprotein Receptor Gene Familial Hypercholesterolemia Variant Database: Update and Pathological Assessment

(2012) Ebele Usifo et al.   ANNALS OF HUMAN GENETICS

Statin treatment of children with familial hypercholesterolemia – Trying to balance incomplete evidence of long-term safety and clinical accountability: Are we approaching a consensus?

(2012) Alpo Vuorio et al.   ATHEROSCLEROSIS

Universal Screening of Cholesterol in Children

(2012) Peter O. Kwiterovich et al.   CLINICAL CARDIOLOGY

The Rationale for Initiating Treatment of Hypercholesterolemia in Young Adulthood

(2012) Daniel Steinberg   Current Atherosclerosis Reports

Familial hypercholesterolemia in children and adolescents

(2012) Brian W. McCrindle   CURRENT OPINION IN LIPIDOLOGY

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia

(2012) Mohammad Mahdi Motazacker et al.   EUROPEAN HEART JOURNAL

Guidelines for the Management of Familial Hypercholesterolemia

(2012) Mariko Harada-Shiba et al.   Journal of Atherosclerosis and Thrombosis

Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia

(2012) Marta Futema et al.   JOURNAL OF MEDICAL GENETICS

Familial hypercholesterolaemia in children and adolescents: A new paediatric model of care

(2012) Andrew C Martin et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Homozygous familial hypercholesterolaemia

(2012) Marina Macchiaiolo et al.   LANCET

Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH

(2012) Ingunn Narverud et al.   THROMBOSIS RESEARCH

Paediatric screening for hypercholesterolaemia in Europe: Table 1

(2011) D M Kusters et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia

(2011) Natacha Bellanger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

(2011) O.S. Descamps et al.   ATHEROSCLEROSIS

Familial hypercholesterolaemia: A model of care for Australasia

(2011) Gerald F. Watts et al.   ATHEROSCLEROSIS SUPPLEMENTS

Reduction in Mortality in Subjects With Homozygous Familial Hypercholesterolemia Associated With Advances in Lipid-Lowering Therapy

(2011) Frederick J. Raal et al.   CIRCULATION

Molecular Basis of Autosomal Dominant Hypercholesterolemia

(2011) Anouk van der Graaf et al.   CIRCULATION

Pregnancy Outcomes in Familial Hypercholesterolemia

(2011) Ieva Toleikyte et al.   CIRCULATION

The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the UK

(2011) Peter S. Sever et al.   EUROPEAN HEART JOURNAL

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

(2011) et al.   EUROPEAN HEART JOURNAL

Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies

(2011) L. Nherera et al.   HEART

Genetic variation inAPOB,PCSK9, andANGPTL3in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels

(2011) Roeland Huijgen et al.   HUMAN MUTATION

Management of Familial Hypercholesterolemias in adult patients: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

(2011) Matthew K. Ito et al.   Journal of Clinical Lipidology

Pediatric aspects of Familial Hypercholesterolemias: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

(2011) Stephen R. Daniels et al.   Journal of Clinical Lipidology

Treatment of adults with Familial Hypercholesterolemia and evidence for treatment: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

(2011) Jennifer G. Robinson et al.   Journal of Clinical Lipidology

Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients

(2011) Anne C. Goldberg et al.   Journal of Clinical Lipidology

Análisis coste-efectividad de un programa de cribado genético en familiares directos de pacientes con hipercolesterolemia familiar en España

(2011) Juan Oliva et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis

(2010) Constantina Masoura et al.   ATHEROSCLEROSIS

Influence of Age on Associations Between Childhood Risk Factors and Carotid Intima-Media Thickness in Adulthood

(2010) Markus Juonala et al.   CIRCULATION

Integrating provision of specialist lipid services with cascade testing for familial hypercholesterolaemia

(2010) Borunendra N Datta et al.   CURRENT OPINION IN LIPIDOLOGY

Lipoprotein(a) as a cardiovascular risk factor: current status

(2010) Børge G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Functionality of sequence variants in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in individuals with inherited hypercholesterolemia

(2010) Roeland Huijgen et al.   HUMAN MUTATION

Positive screening and carrier results for the England-wide universal newborn sickle cell screening programme by ethnicity and area for 2005-07

(2010) A. Streetly et al.   JOURNAL OF CLINICAL PATHOLOGY

Sudden Death in a 4-Year-Old Boy: A Near-Complete Occlusion of the Coronary Artery Caused by an Aggressive Low-Density Lipoprotein Receptor Mutation (W556R) in Homozygous Familial Hypercholesterolemia

(2010) Kurt Widhalm et al.   JOURNAL OF PEDIATRICS

Universal Versus Targeted Blood Cholesterol Screening Among Youth: The CARDIAC Project

(2010) S. K. Ritchie et al.   PEDIATRICS

Management of fertility in women with familial hypercholesterolaemia: summary of NICE guidance

(2009) M Thorogood et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Implementing American Heart Association Pediatric and Adult Nutrition Guidelines

(2009) Samuel S. Gidding et al.   CIRCULATION

Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project

(2009) A Taylor et al.   CLINICAL GENETICS

Cost-effectiveness analysis of the use of a high-intensity statin compared to a low-intensity statin in the management of patients with familial hypercholesterolaemia

(2009) L. Nherera et al.   CURRENT MEDICAL RESEARCH AND OPINION

Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn?

(2009) Hans J Avis et al.   CURRENT OPINION IN LIPIDOLOGY

Genetic testing in asymptomatic minors: recommendations of the European Society of Human Genetics

(2009)   EUROPEAN JOURNAL OF HUMAN GENETICS

Non-adherence to statin therapy: a major challenge for preventive cardiology

(2009) TR Bates et al.   EXPERT OPINION ON PHARMACOTHERAPY

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

(2009) Elaine M. Urbina et al.   HYPERTENSION

Colesevelam Hydrochloride: Efficacy and Safety in Pediatric Subjects with Heterozygous Familial Hypercholesterolemia

(2009) Evan A. Stein et al.   JOURNAL OF PEDIATRICS

Longitudinal Evaluation and Assessment of Cardiovascular Disease in Patients With Homozygous Familial Hypercholesterolemia

(2008) Daniel M. Kolansky et al.   AMERICAN JOURNAL OF CARDIOLOGY

Vascular Calcifications in Homozygote Familial Hypercholesterolemia

(2008) Z. Awan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiovascular disease in familial hypercholesterolaemia: Influence of low-density lipoprotein receptor mutation type and classic risk factors

(2008) R. Alonso et al.   ATHEROSCLEROSIS

Preventing Heart Disease in the 21st Century

(2008) Henry C. McGill et al.   CIRCULATION

Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing

(2008) Brian Starr et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?

(2008) Steve E Humphries et al.   CURRENT OPINION IN LIPIDOLOGY

Cohort Profile: The STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

(2008) O. Simell et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia

(2008) Anouk van der Graaf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis of Familial Hypercholesterolemia in General Practice Using Clinical Diagnostic Criteria or Genetic Testing as Part of Cascade Genetic Screening

(2008) Trond P. Leren et al.   Public Health Genomics

Coste-efectividad del manejo de la hipercolesterolemia familiar con estrategias de tratamiento preventivo basadas en atorvastatina

(2008) Rodrigo Alonso et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Femoral Atherosclerosis In Heterozygous Familial Hypercholesterolemia

(2007) Mireia Junyent et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY