Journal
EUROPEAN HEART JOURNAL
Volume 37, Issue 44, Pages 3347-3356Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehv551
Keywords
Antiplatelet drugs; Aspirin; Myocardial infarction; P2Y(12) receptor; Platelet aggregation; Thromboxane A(2)
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Funding
- AstraZeneca, Sweden
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Aims Patients with acute coronary syndromes (ACSs) are treated with acetylsalicylic acid (ASA) and antagonists of the P2Y(12) receptor (P2Y(12)R) for adenosine diphosphate (ADP). Based on the demonstration that P2Y(12)R antagonists inhibit thromboxane A(2) (TxA(2)) production (target of ASA), it was surmised that ACS patients might be treated with P2Y(12)R antagonists only. However, this demonstration contrasts with the results of previous studies. The aim of this study was to test whether P2Y(12)R antagonists have off-target/indirect inhibitory effects on platelet TxA(2) production. Methods and results We studied 3 patients with inherited P2Y(12)R deficiency and 33 healthy subjects. Serum TxB(2) (TxA(2) metabolite) levels were similar in P2Y(12)R-deficient patients and healthy subjects and were not decreased by P2Y(12)R antagonists in vitro. Serum TxB(2) levels did not decrease in 20 patients treated with prasugrel (10 mg q. i. d.) or placebo for 14 days. Arachidonic acid-and collagen-induced platelet aggregation (PA) and TxB(2) production in platelet-rich plasma (PRP) of healthy subjects were inhibited in vitro by P2Y(12)R antagonists. However, P2Y(12)R antagonists did not inhibit TxB(2) production when PA was prevented by avoiding the stirring of PRP in the aggregometer. The P2Y(1) ADP-receptor antagonist MRS2500 had similar effects on PA and TxB(2) production as P2Y(12)R antagonists. Acetylsalicylic acid inhibited TxB(2) production more effectively than a P2Y(12)R antagonist; only the combination of ASA and a P2Y(12)R antagonist inhibited PA induced by high concentration of collagen. Conclusion Inherited deficiency or pharmacological inhibition of P2Y(12)R does not affect the platelet capacity to synthesize TxA(2). There is no pharmacological evidence that ACS patients may be safely treated with P2Y(12)R antagonists without ASA.
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